Sentences with phrase «generate oxidative stress»

Cellular functions create metabolic processes that generate oxidative stress on the cell.

However, insufficient ROS detoxification or ROS overproduction generates oxidative stress, resulting in cellular damage.

Recurring, excessive postprandial glycemia could decrease blood HDL - cholesterol concentrations, increase triglyceridemia, and also be directly toxic by increasing protein glycation, generating oxidative stress, and causing transient hypercoagulation and impaired endothelial function (21, 22).

Alcohol consumption generates oxidative stress and inflammation and the potential to disrupt endoplasmic reticulum homeostasis; a consequence of this response is to limit the rate of protein synthesis [44], [45].

Not exact matches

Oxidative stress reflects an imbalance between the reactive oxygen that is generated by normal cell metabolism and the cell's ability to handle toxic byproducts from that metabolism.

«The stimulation of a metabolism - sensing enzyme that can regulate specific genes explains how oxidative stress, which is generated throughout the embryo during maternal hyperglycemia, causes malformation of specific embryo structures,» Loeken said.

Oxidative stress is generated by reactive oxygen species (ROS) produced in response to metabolic activity and environmental factors.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

This energy production and other metabolic reactions generate free radicals which cause a condition called oxidative stress.

The correlation between oxidative stress and cortisol is basically this: to make steroid hormones, so it could be testosterone, estrogen, cortisol, to make steroids hormones actually generates a lot of free radicals in the process.

When antioxidants are deficient, oxidative stress generated during exertion leads to lipid peroxidation and tissue necrosis.