Sentences with phrase «generated by antibodies»

A final series of tests confirmed that toxic compounds generated by antibodies kill bacteria without any help from other immune cells, like macrophages.

Not exact matches

In a collaborative project with several project partners and funded by the European Union and the Deutsche Forschungsgemeinschaft novel Sclerostin - inhibiting antibodies were generated and analysed for their suitability as osteoporosis treatment option.

These antibodies appeared to have been initially generated in response to an earlier infection by a related virus that causes dengue.

Aguzzi and his team tested this by generating mimetic antibodies in tissue sections from the cerebellum of mice which have a similar toxicity to that of a prion infection.

The findings highlight a novel way to generate antibodies that recognize and target proteins shared by most influenza A strains rather than those unique to each strain.

B lymphocytes generate the antibodies that protect us against infection by pathogens.

Monoclonal antibodies are generated by clones of a type of white blood cell that have been fused to myeloma (cancer) cells to form fast - growing «hybridomas.»

Wilson says the process traditionally has taken so long that by the time enough new B cells were generated, the flu strain targeted already had mutated into a form no longer vulnerable to the captured crop of antibodies.

In the current study, Vanderbilt researchers led by graduate student Andrew Flyak, the paper's first author, used a high - efficiency method they developed to quickly isolate and generate large quantities of monoclonal human antibodies from the blood of survivors of a 2007 outbreak in Uganda who were infected by the Bundibugyo ebolavirus.

The same Swiss team had reported, in two papers published previously in the journal Nature, a new molecular mechanism that generates broad - spectrum antibodies able to bind red blood cells infected by the parasite and therefore to keep the infection under control.

By cloning rat melanopsin and generating specific antibodies, we show that melanopsin is present in cell bodies, dendrites, and proximal axonal segments of a subset of rat RGCs.

The going theory for this — that antibodies generated by a first bout with dengue bind to a second strain, which helps it multiply in the immune cells — doesn't account for the internal bleeding and tissue damage, says Juthathip Mongkolsapaya of Mahidol University in Bangkok, Thailand.

Some of the anti-influenza antibodies generated by the technique recognized multiple strains of the virus and were able to neutralize its ability to infect cells.

Julie Overbaugh, from the Fred Hutchinson Cancer Research Center in Seattle, USA, and colleagues characterized the antibodies generated in 21 women who were superinfected, that is, infected sequentially at least twice with HIV by different sexual partners.

The researchers plan to intensively study the immune responses generated by therapeutic vaccines, broadly neutralizing antibodies, and latency reversing agents in both acutely infected individuals and also in preclinical studies.

Rabbit monoclonals provide better antigen recognition because the rabbit immune system generates antibody diversity, and optimizes affinity by mechanisms that are more efficient than those of mice and other rodents.

An anti-PD-1 antibody developed by Bristol - Myers Squibb generates excitement with results from a phase I trial showing that, among 236 patients with various types of cancer, the treatment shrank tumors in 28 percent of melanoma patients, 30 percent of patients with kidney cancer, and 18 percent of patients with advanced non-small cell lung cancer.

While much recent research has not been published in this area, there is actually a long history of studies that show: (1) there is a significant number of antigens shared between tumors and embryonic tissues (called «oncofetal antigens») and, consequently, antibodies made against tumors can also recognize embryonic tissues, and vice versa; (2) pregnancy confers some immunity against cancer (accompanied by antibody production against oncofetal antigens), not only against its occurrence but also against its growth; (3) similar to pregnancy, an immune response against cancer can be generated by vaccinating animals with embryonic tissues.

And in the meantime, the free availability of the anticipated glucosepane - detecting antibodies generated by the research that SENS Research Foundation funded at Yale will enable the identification of more suitable animal models for the demonstration of a hard health outcome.

One pair of slides was incubated with the primary antibody (anti PD - L1 monoclonal mouse antibody, clone 5H1, generated by Dr. Lieping Chen, Yale University, New Haven, CT) diluted at 1:75 in ACE block at 4 °C overnight.

Fascinated by the efficient way the human immune system generates a rapid response to create a near - infinite variety of antibodies, researchers have «hijacked» that machinery and used it to evolve a...

The failure of this bivalent AMA1 vaccine to protect children in a Phase 2 trial in Mali [20] may be due to the relatively modest and short - lived nature of the antibody responses generated by the vaccine and / or to the inability to overcome genetic diversity.

To address this, we have generated 22 monoclonal antibodies (mAbs) against aggregates formed by a blood transport protein, transthyretin (TTR), which primarily forms amyloid fibrils in a patient's heart and / or peripheral nerves.

By Day 42, immunized animals generated plasma Abeta antibodies that labeled Abeta plaques in human, AD transgenic mouse and vervet brains; bound Abeta1 - 7; and recognized monomeric and oligomeric Abeta but not full - length amyloid precursor protein nor its C - terminal fragments.

Furthermore, using a phospho - tyrosine [Y] 474 (in - house generated) and a phospho - serine [S] 176 (Cell Signaling, Inc., Danvers, MA) RIPK2 antibodies, we confirmed that active RIPK2 is recognized by these antibodies upon activation with MDP treatment in 293HEK fibroblast and HCT116 colon cancer epithelial cells (Fig. 3E, left panel) and detection of constitutively active RIPK2 in the colon cancer cell line SW480 (Fig. 3E, right panel).

Auto - antibodies generated by wheat against the thyroid, pancreas, and gut typically disappear within 3 to 6 months after removal of wheat from the diet.

So to generate autoimmunity against Neu5gc incorporated in human cells, B cells must first be triggered to form high - affinity anti-Neu5gc antibodies by meeting bacterial pathogens who have incorporated Neu5gc into their cell walls.

This work will build on our previous studies supported by the CHF that describe the technology to generate canine antibody fragment libraries.

Protective antibodies, generated by your dog's immune system in response to the vaccine, start neutralizing venom immediately.