Sentences with phrase «generated by the drug»

By deducting the drug's operating costs, taxes, net investment and working capital requirements from its sales revenues, you arrive at the amount of free cash flow generated by the drug if it becomes commercial.

In either case, the charity will receive a share of any future revenues generated by the drug.

Not exact matches

On Medicare, the government could restrain costs by gaining authority to negotiate prices for prescription drugs, and by reinstating the requirement that drugmakers provide rebates, a policy that generates savings for Medicaid but is barred for Medicare.

Ligand is averaging one new partnership deal a month, and two new drugs were approved by the FDA in Q3 and will soon be generating royalties.

The liberalisation of the movement of capital since 1974 has greatly facilitated the recycling of «dirty money» - from the sale of drugs and arms through to that generated by white collar criminality - in legalised tax havens and, thanks to banking secrecy, through the financial and industrial organisations otherwise respected in countries «of excellence» reputed for their professionalism and democratic institutions.

The new drug - like compounds discovered by Vogel and her co-authors offer hope that using a computer - generated P - gp model, explained here http://bit.ly/1LVmR7a, developed to accurately mimic the physical, chemical and biological functions of the protein in the human body, will speed up the drug discovery process and work in real life as well.

Goats as Drug Factories Initially, GTC generated transgenic goats by microinjecting into the developing nucleus of a one - cell embryo a gene encoding the desired human protein (along with DNA that promotes activation of that gene in milk).

The FDA traditionally has taken a product - specific approach to drug approval decisions by focusing on the data generated and submitted by a drug's manufacturer and balancing the benefits against the known risks to the individual patient.

By applying the algorithm to 2010 data on drug crime reports for Oakland, the researchers generated a predicted rate of drug crime on a map of the city for every day of 2011.

«Our results demonstrate that harmine is able to generate new human neural cells, similarly to the effects of classical antidepressant drugs, which frequently are followed by diverse side effects.

The program works by connecting computer - generated drug profiles — including mechanisms of action, clinical efficacy, and side effects — with information about how a molecule may interact with human proteins in specific diseases, such as ovarian cancer.

Researchers at the University of Michigan have identified how a promising drug in clinical trials for the treatment of obesity and related metabolic disorders improves the metabolism of sugar by generating a new signal between fat cells and the liver.

Conversely, a future drug that prevents PTPD2 from acting in cancer cells could generate therapeutic results — by preventing or reducing HER2 signaling.

Frequent tanners experience withdrawal symptoms when given a drug that overrides the effects of opioids, chemicals that can be naturally produced by the body and generate feelings of euphoria.

«In India, many people believed that pharmacists were generating drug - resistant tuberculosis by dispensing anti-TB medications without prescriptions,» says Dr. Madhukar Pai, Canada Research Chair in Epidemiology & Global Health at McGill University and the paper's joint senior author.

iPS - generated neurons, he says, may be of little use in replicating the fate of motor cells buffeted by a lifetime of drug exposure and other metabolic and environmental influences.

Now an international team of biologists may have found a reason why: a signal generated by the body's immune cells renders the drugs useless.

We are taking advantage of this ability by using Salmonella to carry or generate effective chemotherapeutic drugs, concentrating them at and throughout the tumor.

Wu added that in this respect, the response generated by a neoantigen vaccine is similar to the new wave of combination therapies, which are showing more promise in treating cancers that typically develop resistance to single drugs.

See full infographic: JPGINFOGRAPHIC BY JUDE BUFFUMFueled in part by interest generated by Champions, more and more scientists now use PDX mice to study the potential cancer drug responses of individual patientBY JUDE BUFFUMFueled in part by interest generated by Champions, more and more scientists now use PDX mice to study the potential cancer drug responses of individual patientby interest generated by Champions, more and more scientists now use PDX mice to study the potential cancer drug responses of individual patientby Champions, more and more scientists now use PDX mice to study the potential cancer drug responses of individual patients.

The awards span the broad mission of the NIH and include groundbreaking research, such as engineering immune cells producing drugs at the site of diseased tissue; developing a sensor to rapidly detect antibiotic resistance of a bacterial infection; understanding how certain parasites evade host detection by continually changing their surface proteins; and developing implants that run off the electricity generated from the motion of a beating the heart.

11/10/2008 Anti-Angiogenesis Drugs May Foil Tumors by Building Up Blood Vessels, Not Tearing Them Down, Moores UCSD Cancer Center Scientists Find Scientists have thought that one way to foil a tumor from generating blood vessels to feed its growth — a process called angiogenesis — was by creating drugs aimed at stopping a key vessel growth - promoting proDrugs May Foil Tumors by Building Up Blood Vessels, Not Tearing Them Down, Moores UCSD Cancer Center Scientists Find Scientists have thought that one way to foil a tumor from generating blood vessels to feed its growth — a process called angiogenesis — was by creating drugs aimed at stopping a key vessel growth - promoting prodrugs aimed at stopping a key vessel growth - promoting protein.

While it may take a decade and cost an unusual high investment of USD 1 billion in average to bring a new drug to market, generating resistance to a new drug only requires a short couple of years by bacteria.

Scientists have thought that one way to foil a tumor from generating blood vessels to feed its growth — a process called angiogenesis — was by creating drugs aimed at stopping a key vessel growth - promoting protein.

From 2008 - 2010, he was supported by the CGGH to study phenotypic variation in the drug sensitivity of Plasmodium falciparum isolates collected Kilifi District, and to investigate genotype - phenotype associations using genome sequencing data generated on these isolates at the Wellcome Trust Sanger Institute.

Very importantly, DDI types predicted by DeepDDI are generated in the form of human - readable sentences as outputs, which describe changes in pharmacological effects and / or the risk of ADEs as a result of the interaction between two drugs in pair.

By enabling compound binding profiles to be rapidly generated, the HuProt microarray has become an indispensible tool at the forefront of drug discovery and development..

The final aim is improving therapeutic effect and defining rationalized drug combinations with immune checkpoints and proprietary molecules developed by collaborators, including novel immunomodulatory approaches generated at our unit.

Today, Carpenter's lab continues those efforts as her team works to accelerate drug discovery by writing software to automatically analyze the deluge of cellular images generated by today's powerful, robotic microscopes.

By carefully studying why a rare blood disorder responds to the anti-cancer drug Gleevec, researchers have discovered an entirely new mechanism that generates cancer - causing genes.

Bixin has also been shown to intercept free radicals generated by commonly used chemotherapeutic drugs, and some studies suggest that supplementation with beta - carotene and achiote can help manage diabetes.

That's because your doctor has been brainwashed or bribed by the drug companies that now generate $ 29 billion dollars a year from selling statin drugs.

As a result of the data generated by scientists at U.S. Department of Agriculture and Food and Drug Administration, EWG created its Dirty Dozen ™ list of foods most commonly contaminated with pesticides, as well as, the Clean Fifteen ™ list of the foods least likely to be pesticide - tainted.

In this case, by playing Fold.it, the gamers generated models that were good enough for the researchers to determine the enzyme's actual structure, something that in turn could help scientists develop drugs to target the enzyme.

A Medical Review Officer (MRO) is a person who is a licensed physician and who is responsible for receiving and reviewing laboratory results generated by an employer's drug testing program and evaluating medical explanations for certain drug test results.

Being a part of the class of drugs that inhibit the action of a family of enzymes known as the Janus Kinases or JAKs, JAK Inhibitors effectively block the signals generated by various cytokines.

Since the NSAID Ibuprofen was released as an over-the-counter tablet, it has generated more calls to the National Animal Poison Control Center by dog and cat owners than has any other single drug.

The drug within the tumor is activated by a specific wavelength of light to generate intracellular oxygen and lead to death of cells and / or loss of blood supply.

Some years ago excitement was generated by the news that a group of drugs could help control the progress of the condition by acting on one of the chemicals whose regulation in the brain appears to be associated with the disease process.

Legalize and Regulate Marijuana WHEREAS, despite almost a century of prohibition, millions of Canadians today regularly consume marijuana and other cannabis products; WHEREAS the failed prohibition of marijuana has exhausted countless billions of dollars spent on ineffective or incomplete enforcement and has resulted in unnecessarily dangerous and expensive congestion in our judicial system; WHEREAS various marijuana decriminalization or legalization policy prescriptions have been recommended by the 1969 - 72 Commission of Enquiry into the Non-Medical Use of Drugs, the 2002 Canadian Senate Special Committee on Illegal Drugs, and the 2002 House of Commons Special Committee on the Non-Medical Use of Drugs; WHEREAS the legal status quo for the criminal regulation of marijuana continues to endanger Canadians by generating significant resources for gang - related violent criminal activity and weapons smuggling — a reality which could be very easily confronted by the regulation and legitimization of Canada's marijuana industry; BE IT RESOLVED that a new Liberal government will legalize marijuana and ensure the regulation and taxation of its production, distribution, and use, while enacting strict penalties for illegal trafficking, illegal importation and exportation, and impaired driving; BE IT FURTHER RESOLVED that a new Liberal government will invest significant resources in prevention and education programs designed to promote awareness of the health risks and consequences of marijuana use and dependency, especially amongst youth; BE IT FURTHER RESOLVED that a new Liberal government will extend amnesty to all Canadians previously convicted of simple and minimal marijuana possession, and ensure the elimination of all criminal records related thereto; BE IT FURTHER RESOLVED that a new Liberal government will work with the provinces and local governments of Canada on a coordinated regulatory approach to marijuana which maintains significant federal responsibility for marijuana control while respecting provincial health jurisdiction and particular regional concerns and practices.

Although the number of people using this drug has remained stable between 2010 and 2013, concerns have been generated by the fact that an increase has been shown to have occurred in the number of meth / amphetamine users who are choosing to use the purer, more potent form of this drug - crystal methamphetamine (ice)- which has the potential to cause more severe problems.