This strip of cardiac muscle was
generated from embryonic stem cells that... (Spencer Platt / Getty Images)
The answer to this question comes from the lab of Marcel Leist (University of Konstanz, Germany) and their studies employing a defined and controllable in vitro system of post-mitotic murine astrocytes
generated from embryonic stem cells (mAGES)[1].
Mice
generated from embryonic stem cells in which ion channel genes have been mutated by homologous recombination often have a perfectly normal heart.
The IMPC envisages a ten year programme to undertake a broad - based, systematic genome - wide phenotyping project of knockout mice
generated from the embryonic stem cell mutant resources developed by the International Knock - out Mouse Consortium (IKMC).
Not exact matches
Oliver Brüstle, director of the Institute of Reconstructive Neurobiology at the University of Bonn, Germany, who had a patent on a method for
generating neurons
from human
embryonic stem cells rejected by the court, called the ruling «the worst possible outcome», and «a disaster for Europe».
This year they succeeded in
generating mini-livers, or liver buds,
from stem cells that were taken
from human skin and reprogrammed to an
embryonic state.
In one promising approach, cellular reprogramming,
stem cells can be
generated by fusing adult skin
cells with
embryonic stem cells from existing
cell lines.
Because burgeoning teeth depend on information
from the budding
embryonic jaw, work toward
generating replacement teeth
from dental
stem cells focuses on growing them in the desired location in the recipient's mouth — but scientists are not yet sure the adult jaw can provide the necessary signals to shape made - to - order teeth.
For the purpose of additional experiments, the researchers
generated myocardial
cells from embryonic stem cells and human skin
cells, in collaboration with the lab headed by Prof Dr Jürgen Hescheler at the University of Cologne.
Organlike tissue bits can be
generated from pluripotent
stem cells that are either plucked
from embryos or created by taking a person's adult skin or blood
cells and chemically inducing them to revert to an
embryonic - like state.
Stem cells from adult bone marrow normally generate bone, muscle, cartilage and fat cellsa limited set compared with embryonic stem cells, which can spawn the full spectrum of adult tiss
Stem cells from adult bone marrow normally
generate bone, muscle, cartilage and fat cellsa limited set compared with
embryonic stem cells, which can spawn the full spectrum of adult tiss
stem cells, which can spawn the full spectrum of adult tissues.
Using mouse
embryonic stem cells that
generate motor neurons as a model, the researchers found that CTCF isolates Hox genes
from harmful activation.
Opponents have argued that the law should be rescinded since
embryonic stem cells can now be
generated from induced pluripotent
stem cells, a technique that does not involve human embryos.
Australian researchers have so far
generated over 50
embryonic stem cell lines
from surplus embryos, and three research groups have been licensed to attempt somatic
cell nuclear transfer.
Next, the team used both human
embryonic NPCs and human NPCs
generated from stem cells to tweak the protocol for human use.
Specifically, the researchers
generated the tissue
from human
embryonic stem cells with the resulting muscle having significant similarities to human heart muscle.
Pluripotency distinguishes
embryonic stem cells from adult
stem cells found in adults; while
embryonic stem cells can
generate all
cell types in the body, adult
stem cells are multipotent and can produce only a limited number of
cell types.
In 2009, Reijo Pera showed that it is possible to
generate functional, sperm - producing germ
cells from human
embryonic stem cells grown under certain conditions in the laboratory.
Scientists in the lab have successfully
generated neural
stem cells (NCS)
from human
embryonic stem cells and human induced pluripotent
stem cells (these are
stem cells that have been reprogrammed
from adult
cells).
NeuroStemcell is focused on the identification and systematic comparison of progenitor
cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation,
generated either directly
from human
embryonic stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
stem (ES)
cells,
from Neural
Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (NS)
cells derived
from ES
cells or fetal brain,
from induced Pluripotent
Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (iPS)
cells or
from in vitro short - term expanded neural progenitors
from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate
cells in appropriate animals models.
Pancreatic endoderm derived
from human
embryonic stem cells generates glucose - responsive insulin - secreting
cells in vivo.
Pluripotent
cells such as
embryonic stem (ES) and induced pluripotent
stem (iPS)
cells are the starting point
from which to
generate organ specific
cell types.
Platelets
generated from human
embryonic stem cells are functional in vitro and in the microcirculation of living mice.
The team that
generated the insulin - producing
embryonic stem cell line, e.g., had a success rate of under six percent, using 71 eggs to produce four
stem cell lines
from the embryos they created and destroyed.
One of those teams created a cloned embryo
from the somatic
cells of a diabetic patient; this embryo was then destroyed in order to
generate an insulin - producing
embryonic stem cell line.
A team of UK
stem cell scientists, led by Dr. Robin Ali
from UCL Institute of Ophthalmology in London, has developed a new strategy for repairing the retina by transplanting photoreceptor
cells generated in the laboratory
from embryonic stem cells.
One of his early achievements came
from his demonstration that techniques used in preimplantation genetic diagnosis could be used to
generate human
embryonic stem cells (hESCs) without
embryonic destruction.
Starting with transplants of human oligodendrocytes in the late 1980s [40], and more recently with populations of human oligodendrocyte progenitor
cells isolated
from the developing or adult CNS, or
from human
embryonic stem cells, it has been possible to
generate extensive myelination upon transplantation into spinal cord injury or into congenital mouse models of hypomyelination [41]--[48].
To explore this question, they
generated neural
cells from embryonic stem cells and then removed DNMT3A
from the cellular environment.
Prof. Dr. Ivan Martin's research group at the Department of Biomedicine has now been able to demonstrate that by forcing certain molecular events occurring during the
embryonic development of articular cartilage it is possible to
generate stable cartilage tissue
from adult human mesenchymal
stem cells.
Human pluripotent
stem cells derived from embryos (human Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell ty
stem cells derived from embryos (human Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell t
cells derived
from embryos (human
Embryonic Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell ty
Stem Cells or hESCs) or generated by direct reprogramming of somatic cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell t
Cells or hESCs) or
generated by direct reprogramming of somatic
cells (human Induced Pluripotent Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell t
cells (human Induced Pluripotent
Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell ty
Stem Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of cell t
Cells or hiPSCs) can proliferate almost indefinitely in vitro while maintaining the capacity to differentiate into a broad diversity of
cell types.