Sentences with phrase «generated human and mouse»

They found evidence of Del - 1 in the same areas as osteoclast activity, then followed up by generating human and mouse osteoclasts in vitro and found Del - 1 mRNA and protein expressed at high levels.

Not exact matches

Prof. Marine and his team generated a refined mouse model that faithfully reproduces the early stages of melanoma development in humans.

The «training data» were generated from 78 mice infected with influenza or the cytomegalovirus (CMV) and 32 humans infected with flu, CMV or the Epstein - Barr virus.

Like the per gene, the new genes — dubbed RIGUI in humans and m - rigui in mice — are turned on and off in a daily cycle and may work with other genes to generate the oscillating mechanism that runs the internal clock.

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

«We identified that the peculiar look of these naked lizards is due to the disruption of the ectodysplasin - A (EDA), a gene whose mutations in humans and mice are known to generate substantial abnormalities in the development of teeth, glands, nails and hairs», says Michel Milinkovitch.

In his current position at The Jackson Laboratory, he has overall responsibility for the ongoing operational development of the PDX resource, which generates, banks, and distributes patient - derived xenograft (PDX) mouse models of human cancers.

TOKYO — A Japanese group has generated functional human livers by creating liver precursor cells in the laboratory and then transplanting them into mice to complete the developmental process.

North says his group has already generated a human chimeric form of MAG - 1 that is equally effective as mouse MAG - 1, and they are now generating a humanized form for use in patients.

To develop a model for generating the human colon, scientists first identified SATB2 (special AT - rich sequence - binding protein 2) as a definitive molecular marker for hindgut in frogs, mice and in humans.

After successfully generating mouse iPSCs, Yamanaka and Takahashi began a similar search for the reprogramming factors that would create human iPSCs.

Harmonising ontological descriptions of phenotype in mouse and human and improving links between mouse model data and human data, using diabetes and obesity as examples, will increase the relevance of data that is generated in mouse studies for clinical studies.

Bethesda, Md., Thurs., Sept. 29, 2011 — Over the next five years, National Institutes of Health (NIH)- funded researchers will extensively test and generate data about mice with disrupted genes to gain clues about human diseases.

By carefully guiding the cells» choices at each fork in the road, Loh and Chen were able to generate bone cell precursors that formed human bone when transplanted into laboratory mice and beating heart muscle cells, as well as 10 other mesodermal - derived cell lineages.

Although CRISPR is incredibly useful for generating mutations by NHEJ and generating small mutations with HDR, when it comes to larger scale genome editing, such as replacement of a mouse gene with its human ortholog (greater than 5 kb), it remains to be seen whether CRISPR is as robust as conventional gene targeting.

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice.

While earlier work has reported persistence of HIV in these cells — macrophages — investigators in this work developed a mouse model with an immune system generated from human cells but lacking T cells, which are a primary target of and reservoir for HIV.

These mice will be preserved in repositories and made available to the scientific community representing a valuable resource for basic scientific research as well as generating new models for human diseases.

Starting with transplants of human oligodendrocytes in the late 1980s [40], and more recently with populations of human oligodendrocyte progenitor cells isolated from the developing or adult CNS, or from human embryonic stem cells, it has been possible to generate extensive myelination upon transplantation into spinal cord injury or into congenital mouse models of hypomyelination [41]--[48].

Izpisua Belmonte and colleagues published work in the journal Nature last year reporting that they had been able to integrate human stem cells into early - stage mouse embryos so that the human stem cells began the first stages of differentiation — they appeared to begin the process of generating precursors of the body's various tissues and organs.

Pluripotent stem cells can be generated from adult mouse - tail tip fibroblasts and adult human fibroblasts by the retrovirus - mediated transfection of four transcription factors, Oct3 / 4, Sox2, c - Myc, and Klf4.

By Day 42, immunized animals generated plasma Abeta antibodies that labeled Abeta plaques in human, AD transgenic mouse and vervet brains; bound Abeta1 - 7; and recognized monomeric and oligomeric Abeta but not full - length amyloid precursor protein nor its C - terminal fragments.

A recent study led by BSI member Professor Andrew Sewell from Cardiff University and published in the Journal of Clinical Investigation showed that a synthetic «mirror image» version of a protein belonging to the influenza A virus generated strong immune responses in human cells and mice, with the mice also being protected when exposed to a strain of influenza A.

In the present study, we used a combination of BAC clone contig construction, polymorphism analysis of DNA from congenic strains, and sequence mining of the human orthologous region to generate an integrated map of the Idd10 region on mouse chromosome 3.

Numerous mouse models have been generated to examine the pathogenesis of the disease and to evaluate therapeutic approaches, but the most precise genetic reproductions of the human condition are the knock - in (KI) mouse models which express the huntingtin mutation in the proper genetic and protein context on the murine gene.

These mice were created and deposited by The Pleiades Promoter Project (Centre for Molecular Medicine and Therapeutics, University of British Columbia); their goal is to generate 160 fully characterized, human DNA promoters of less than 4 kb (MiniPromoters) to drive gene expression in defined brain regions of therapeutic interest for studying disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic Lateral Sclerosis (Lou Gehrig's disease), Multiple Sclerosis, Spinocerebellar Ataxia, Depression, Autism, and Cancer.

Created by the New York animators the Fleischer Brothers (Max, the eldest of the three, produced; Lou animated and later supervised the music; their little brother, Dave, directed), she was, as the animation historian Donald Crafton puts it in his recent study, «Shadow of a Mouse» (University of California Press), «one of the earliest cartoon characters to be a fully fleshed - out human being and the only classic» toon star generated as female (neither Minnie nor Daisy were leading ladies).»