Sentences with phrase «generated human neurons»

Her lab is using stem cells to study the function of the disease - causing gene and to generate human neurons suitable for transplantation and pharmacological screening.

Not exact matches

Panksepp saw that human emotions and emotional problems could be explored by studying other mammals — how their brains generated emotions akin to the anger, sadness and joy that humans describe, what neurons and neural circuits were involved.

Oliver Brüstle, director of the Institute of Reconstructive Neurobiology at the University of Bonn, Germany, who had a patent on a method for generating neurons from human embryonic stem cells rejected by the court, called the ruling «the worst possible outcome», and «a disaster for Europe».

Brain neurons are generated from stem cells called basal progenitors that are able to proliferate in humans, but not in mice.

At some point in their development, all embryos — whether human, chimp, rat, frog, or slug — must have a single first cell committed toward generating neurons.

For the new study, the team used a cell - reprogramming technique (similar to those used to reprogram skin cells into stem cells) to generate human DRG - type sensory neurons from ordinary skin cells called fibroblasts.

In tests using human neural progenitor cells (NPCs)-- self - renewing, multipotent cells that generate neurons and other brain cell types — the scientists found that exposure to sofosbuvir not only rescued dying NPCs infected with the Zika virus, but restored gene expression linked to their antiviral response.

She added that, «attempts to generate the cerebellum from human iPS cells have already met with some success, and these patient - derived cerebellar neurons and tissues will be useful for modeling cerebellar diseases such as spinocerebellar ataxia.»

Motor nerve - like tissue (right) was generated using human induced pluripotent stem cell - derived motor neurons (left).

US scientists have successfully generated hypothalamic - like neurons from human induced pluripotent stem cells (hiPSCs) taken from the blood and skin cells of super-obese individuals and people with a normal body weight.

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

This slide summarizes the attempts of various labs all over the world to generate different subtypes of neurons from fibroblasts, both of mouse, but, importantly, also human origin.

In that context, the goal of this project is to infect relevant human host cells (monomacs, neuronal stem cells and differentiated neurons) with parasites of differing lineages to generate transcriptional mRNA and miRNA profiles.

«If we can pinpoint which genes control the development of each neuron type, we can generate them in the petri dish from a single sample of human skin cells,» said Dr. Huang.

«Because I'm interested in developing therapeutics, I need a system that generates billions of human neurons that have the particular mutations for this disease,» he says.

An fMRI - generated connectome of the human brain that shows active connections between neurons (Credit: Alfred Pasieka / Science Photo Library)

Transplantation of astrocytes generated by exposure of human glial progenitor cells (hGPCs) to BMP (hGDAsBMP) promoted robust behavioral recovery and multi-laminae protection of spinal cord neurons following spinal cord injury (SCI), while transplantation of undifferentiated hGPCs or astrocytes generated by hGPC exposure to CNTF (hGDAsCNTF) failed to provide such benefits.

An fMRI - generated connectome of the human brain that shows active connections between neurons