Sentences with phrase «generation drug in»

The next generation drug in the taxane family, cabazitaxel, was approved in 2010, but only for patients whose cancer no longer responded to hormone therapy or docetaxel treatment.

Not exact matches

Kite Pharma, one of the companies chasing a new generation of cancer drugs called chimeric antigen receptor T - cell (CAR - T) therapies, announced a patient death in a clinical trial of its experimental KTE - C19.

MedSleep's MacFarlane points out, however, that many of these concerns have been addressed in the latest generation of drugs, such as Ambien and Lunesta.

The ongoing American Heart Association (AHA) meeting in New Orleans is producing a deluge of data — including some promising prospects for a class of next - generation cholesterol drugs that have been slow to take off so far in the U.S. So - called PCSK9 inhibitors have shown tremendous efficacy in lowering LDL - C, or «bad» cholesterol.

The six cartels that the DEA judges to have the greatest drug - trafficking influence in the US are the Sinaloa, Jalisco New Generation, Juarez, and Gulf cartels and the Beltran Leyva Organization.

These ineffective treatments often leave in their wake surviving microbes that develop resistance to the drugs used and then pass along those adaptations to subsequent generations.

«The fourth generation is involved now, and they want to drive the group to bigger and better things,» Wynne Powell, London Air Services president (and longtime London Drugs boss), told the Vancouver Sun in 2015, by way of explaining plans to divest the seven - plane corporate charter airline.

At the same time, the next generation of multi-billion-dollar drugs takes time to build the billions in sales needed to make the best - seller list — but can be expected to do so starting next year.

Sierra Oncology, Inc., a clinical stage drug development company focused on advancing next - generation DNA damage response therapeutics for the treatment of patients with cancer, went public near $ 29 in July 2015, then began a downtrend that continued through a June 2017 all - time low of $ 1.10.

Interviews with former Sprout employees, analysts, investors and doctors who helped bring the drug to market suggest how a series of missteps after the deal, along with turbulence from aggressive accounting practices, unusual business relationships and big egos, derailed one of the most intriguing new pharmaceuticals in a generation.

Medicine and a host of next generation drugs, procedures, and gene therapies rely HEAVILY on evolutionary theory in their development and application.

According to the third thesis in the canonical narrative, a losing struggle in the fetid jungles of Vietnam destroyed American troop morale and discipline; this disintegration led to rampant drug abuse, the murder of unpopular officers, atrocities like the My Lai murders, and a generation of physically and psychologically scarred veterans.

I look at our world - the unemployment rates, the homeless rates, the drug addiction rates, the degradation we do to our environment, and I don't exactly wish we had millions more people in my generation to add to the problems.

The sixties generation's inordinate self - regard; their demand to be given, without striving for it, all the goodies their society had to offer, including, of course, easy sex; their recourse to the instant and unearned sense of power and comfort supplied by drugs; their refusal to serve their country; their general ingratitude, expressed most of all in their declared intention to lead lives in no respect like those of their forebears — all these were translations of the hubris that, partly unconsciously but entirely influentially, constituted the basic underpinning of their upbringing.

Travis Tygart, president of the USADA, said in a statement, «This is a heartbreaking example of how the win - at - all - costs culture of sport, if left unchecked, will overtake fair, safe and honest competition, but for clean athletes, it is a reassuring reminder that there is hope for future generations to compete on a level playing field without the use of performance - enhancing drugs»...

A 2005 study in the American Journal of Clinical Nutrition found that consuming almonds as part of a heart - healthy diet can be just as effective at lowering LDL «bad» cholesterol levels as first generation statin drugs.

those who are in the public eye specially sports personalities have to set an example to the younger generation, so yes i see a problem with any famous personality's smoking, drugs, driving fast, extramarital affairs, all things we the ordinary folk love to do but they cant

In many ways, epidurals are the drug trip of the current generation.

This is arguably the most important moment in British drug policy for a generation.

(Posted 24 December 2011) Significant current scandals, and those yet to come In no particular order Top salaries and bonuses - boardroom and shareholder individual responsibility The multiple between top and average pay Lawyers fees - the cost of the legal process Medical negligence claims against the NHS Care and treatment in the NHS «No win, no fee» personal injury compensation Democracy and the voting system Lords reform Political party funding The domestic energy market and pricing The Tax system and its inefficiencies and complexities Subsidies for new energy generation schemes The amount of crime fuelled by Drugs The availability of drugs in prisoIn no particular order Top salaries and bonuses - boardroom and shareholder individual responsibility The multiple between top and average pay Lawyers fees - the cost of the legal process Medical negligence claims against the NHS Care and treatment in the NHS «No win, no fee» personal injury compensation Democracy and the voting system Lords reform Political party funding The domestic energy market and pricing The Tax system and its inefficiencies and complexities Subsidies for new energy generation schemes The amount of crime fuelled by Drugs The availability of drugs in prisoin the NHS «No win, no fee» personal injury compensation Democracy and the voting system Lords reform Political party funding The domestic energy market and pricing The Tax system and its inefficiencies and complexities Subsidies for new energy generation schemes The amount of crime fuelled by Drugs The availability of drugs in prDrugs The availability of drugs in prdrugs in prisoin prison.

The psychoactive substances bill sought to crack down on legal highs — especially the new generation of drugs that are designed to mimic the effects of traditional illicit substances such as cannabis and ecstasy — which the Home Office says caused 129 deaths in 2015.

«We need an all - hands - on - deck approach to combat this unprecedented drug epidemic, which threatens a generation of Islanders, and we must be ever vigilant to ensure that we maintain the high quality of life that has made this borough one of the safest places to live in this country.

Brought up in a council house in North Kensington by his mother, Bailey is a co-founder of My Generation, a charity that encourages young people to take greater responsibility in tackling drug use and antisocial behaviour.

Early generations of Moderna's drugs didn't meet that standard in animal tests, acknowledges its president, Stephen Hoge; over time, liver toxicity and immune reactions reared their heads.

A new generation of drugs promises diagnosis, monitoring, stealth, precision and cure — all in one package

«We have developed a drug candidate, a next - generation biologic medical product, and are now publishing the fantastic results from the preclinical part where wound healing was strongly accelerated in mice,» says Mia Phillipson, Professor at the Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University.

A new generation of long - established drugs could also play an important role in the treatment of postpartum depression in future.

It hasn't revealed which modified nucleoside is in its newest generation of drug candidates.

He notes, however, that in the wake of the criminalization of first - generation cathinone derivatives, new members of this drug class are being invented that will also require study.

Until RDTs became widespread, almost all fevers were treated as if they were malaria, leading to the overuse of the new generation of «wonder drugs,» artemisinin - based combination therapies (ACTs), which were in danger of being lost to drug resistance.

They are primarily being used to package and deliver the current generation of cancer cell killing drugs and progress is being made in that effort.

They enabled health workers in remote villages in Africa and Asia to accurately and almost instantly diagnose malaria, making them less likely to overuse the new generation of «wonder drugs,» artemisinin - based combination therapies (ACTs), which were in danger of being lost to drug resistance.

«Finding increased vulnerability to drug addiction and compulsive behavior in generations not directly exposed is an important consideration for legislators considering legalizing marijuana.»

The newer generation of anti-inflammatory drugs, the COX - 2 selective inhibitors, do not have gastrointestinal side effects, but at least one of them is reported to lead to an increase in thrombotic events.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

The researchers are now examining whether CK2 - inhibitors can effectively reduce obesity as well as prevent it, and whether they can be used alongside next - generation drugs that mimic the effects of cold to trigger brown fat to burn energy in humans.

In reality, such incidents are usually brief and generally do not involve pain or distress, but they do highlight one of several ways that even the newest generation of anesthetic drugs can sometimes leave much to be desired.

Many Africans get their malaria drugs in the private sector, from local pharmacies or village shops, where the latest and most effective generation of drugs, the so - called artemisinin - based combination therapies (ACTs), are often hard to find and expensive.

It also provides valuable information that may assist researchers in the development of genetic tests based on next generation sequencing, and in the initiation of large intervention trials to assess the efficacy of orphan drugs.

Poon believes this discovery will spawn a new generation of programmable microimplants — sensors to monitor vital functions deep inside the body; electrostimulators to change neural signals in the brain; and drug delivery systems to apply medicines directly to affected areas.

In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers — triple negative breast canceIn a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers — triple negative breast cancein animal models in one of the hardest to treat cancers — triple negative breast cancein one of the hardest to treat cancers — triple negative breast cancer.

First - generation drugs are now in the final phase of human testing

In animal experiments, the drug reduces the size of tumors that are resistant to earlier - generation mTOR inhibitors.

U.S. Secretary of State Hillary Clinton today declared that recent scientific advances in HIV / AIDS have created a «historic opportunity» to change the course of the pandemic and usher in a generation where no children are born with the virus, the risk of becoming infected plummets for teens and adults, and those who do become infected receive drugs that both ward off disease and make them less infectious.

An explosion of recent studies in both animals and people suggests that resident microbes can influence susceptibility to diseases from HIV to asthma, predispose to obesity across generations, and tinker with how the body responds to drugs.

«If knocking out this other hydrogenase also drastically reduces long - term survival, the enzyme might end up being an excellent next - generation drug target in latent TB infections, which around one - third of the world's population suffer.

Given the role of Msi in promoting aggressive disease, the investigators partnered with Robert MacLeod PhD, vice-president of oncology drug discovery at Ionis Pharmaceuticals, to develop next - generation antisense oligonucleotide (ASO) inhibitors against Msi.

The ultimate goal is to precisely understand the mechanisms of checkpoint blockade effectiveness and bring next generation, sustainable immunotherapies to even more patients, perhaps using by using epigenetic drugs in combination with checkpoint blockade to allow epigenetic reprogramming of exhausted T cells into durable and functional memory T cells.

Meanwhile, the inaccuracies and sensationalism of the mainstream media in its approach to reporting on drugs can only hasten its already diminishing relevance to the generation that is more likely to trust what it reads on Twitter and Facebook.

A team led by Eric Klann and Moses Chao at New York University analyzed neurons in culture and in live mice to see what happened at the molecular level when neurons were exposed to haloperidol, a first - generation drug for schizophrenia.