Not exact matches
Next -
generation «designer matrices» such as hybrid polyethylene glycol hydrogels or microengineered collagen scaffolds, combined with a well - defined set
of laminins, may better fulfill the niche requirements
of organoids and may be customized for a specific type
of tissue /
organoid (2,6).
Due to the high efficiency
of establishing
organoid models from different tissues and diseases, such as cancer,
organoid technology allows the
generation of large living biobanks
of tumor
organoids that are amenable for middle - throughput drug screens and may allow personalized therapy design, as a complement to cell line and xenograft - based drug studies (7,19).
A study by Pauli and colleagues in this issue
of Cancer Discovery describes the creation
of a precision cancer platform for patients with advanced disease, integrating DNA sequencing
of patient tumors with the
generation of patient - derived
organoids and xenografts.
This poster describes the isolation and maintenance in culture
of pluripotent stem cells, their differentiation, and the
generation and potential uses
of organoids.
Two phrases made Lunshof sit up: «embryo - like features» and «
generation of cerebral
organoids.»