Sentences with phrase «generation sequencing studies»

Recent technological advances have enabled genome - wide association studies and emerging next - generation sequencing studies to begin to decipher the nature of the heritable contribution to traits and disease.

The role of heredity in obesity appears to be between 40 and 70 percent, and next - generation sequencing studies of whole genomes (GWAS) have uncovered about 100 common genetic variants that explain a small amount of variation leading to obesity.

Not exact matches

We scored risk of bias related to random sequence generation, allocation concealment, and selective reporting as unclear for the majority of the studies due to lack of information.Our primary outcome was pain.

In two studies, with respect to sequence generation and allocation concealment, these domains were either not described or were unclear (Sellen 2013; Winterburn 2003).

Three studies used adequate methods for random sequence generation, but their methods for allocation concealment were not clear (Paul 2012; Penfold 2014; Serwint 1996).

The researchers used next generation sequencing technology, RNA sequencing, to reveal «in exquisite detail» the blueprint for making milk in the human mammary gland, according to Laurie Nommsen - Rivers, PhD, RD, IBCLC, a scientist at Cincinnati Children's and corresponding author of the study, published online in PLOS ONE, a journal of the Public Library of Science.

Nine studies reported genuine random methods of generation of the randomisation sequence (Begley 2011; Biro 2000; Harvey 1996; Hicks 2003; Homer 2001; MacVicar 1993; McLachlan 2012; Rowley 1995; Turnbull 1996).

«Our work demonstrates that the generation of genome sequences from a large number of archaic human individuals is now technically feasible, and opens the possibility to study Neandertal populations across their temporal and geographical range,» says Janet Kelso, the senior author of the new study.

The new study, led by Johannes Krause, a geneticist at the Max Planck Institute for the Science of Human History in Jena, Germany, used next - generation sequencing methods to read stretches of any DNA present in a sample and fish out those that resembled human DNA.

The authors of this study have developed a universal primer set across flowering plants that amplifies 3 - 15 kilobase fragments, which can then easily be sequenced using recently developed next - generation sequencing technologies.

«This study is remarkably comprehensive, which will help any molecular laboratory design and implement their own next - generation sequencing lymphoma panel using this work as a template,» commented Robert S. Ohgami, MD, PhD, Assistant Professor of Pathology at the Stanford University Medical Center, in an accompanying editorial.

«This study demonstrates the potential of combining functional profiling of cells with the characterizations of cancer genomes via next generation sequencing,» said co-senior author Jill P. Mesirov, PhD, professor and associate vice chancellor for computational health sciences at UC San Diego School of Medicine.

Break - seq combines an existing double strand break labeling system the researchers had used in an earlier study with next generation sequencing to map chromosome breaks with improved sensitivity and resolution.

A University of Colorado Cancer Center study published in the journal Oncogene used next - generation sequencing technologies to perform the most detailed DNA - based analysis to date of 25 commonly used bladder cancer cell lines, allowing researchers to match patient tumors with their closest genetic cell line match, and demonstrated genetic alterations that may make cells more or less sensitive to common therapies.

Researchers from Sanford Health and Chronix Biomedical today announced that results from a pilot study demonstrating the utility of a new cancer panel to detect previously undetected viral and cancer mutations are to be reported in a poster presentation titled «Detection of novel HPV mutations and chromosomal number imbalance (CNI) in oropharyngeal and laryngeal cancer using next - generation sequencing (NGS)» at the American Society of Clinical Oncology Annual Meeting (ASCO 2014) being held from May 30 through June 3, 2014 in Chicago.

Dr. James Beck of Wichita State University and Dr. John Semple, at the University of Waterloo, have collaborated on a new study highlighting the role of herbarium sampling coupled with cutting - edge next - generation sequencing technologies to better understand plant diversity.

There are few studies to date looking at the feasibility and diagnostic success rate of next - generation sequencing in the NICU.

Canadian researchers conducted a pilot study with 20 newborns to determine the effectiveness of a targeted next - generation sequencing panel that included all 4813 genes currently known to be associated with rare diseases.

«Scientists challenge next - generation sequencing dogma: Surprising bacteria study reveals that shotgun sequencing misses major groups of organisms despite producing more data than amplicon sequencing.»

«Next - generation sequencing technology has allowed us to find new causes of genetic diseases in much smaller families,» explained the study's lead author, William Motley, MD, PhD, a resident physician in Medicine.

«Our results using advanced, modern laboratory techniques called next - generation sequencing, allowed us to acquire a library of new knowledge about patients with ALS,» says the study's senior author, Leonard Petrucelli, Ph.D., chair of the Department of Neuroscience on Mayo Clinic's Florida campus.

The Human Microbiome Project, funded by the US National Institutes of Health, has now used next - generation DNA sequencing technology to study these microbes straight from the source.

Several methodologies for performing DNA target enrichment prior to next generation sequencing have been developed and utilized in a growing number of experimental studies.

In a separate study which is not yet published, this team with Professor Steve Rozen, from the NBD Programme at Duke - NUS, identified many new mutations in the PCM1 gene from ASD patients from next - generation sequencing.

g (acceleration due to gravity) G (gravitational constant) G star G1.9 +0.3 gabbro Gabor, Dennis (1900 — 1979) Gabriel's Horn Gacrux (Gamma Crucis) gadolinium Gagarin, Yuri Alexeyevich (1934 — 1968) Gagarin Cosmonaut Training Center GAIA Gaia Hypothesis galactic anticenter galactic bulge galactic center Galactic Club galactic coordinates galactic disk galactic empire galactic equator galactic habitable zone galactic halo galactic magnetic field galactic noise galactic plane galactic rotation galactose Galatea GALAXIES galaxy galaxy cannibalism galaxy classification galaxy formation galaxy interaction galaxy merger Galaxy, The Galaxy satellite series Gale Crater Galen (c. AD 129 — c. 216) galena GALEX (Galaxy Evolution Explorer) Galilean satellites Galilean telescope Galileo (Galilei, Galileo)(1564 — 1642) Galileo (spacecraft) Galileo Europa Mission (GEM) Galileo satellite navigation system gall gall bladder Galle, Johann Gottfried (1812 — 1910) gallic acid gallium gallon gallstone Galois, Évariste (1811 — 1832) Galois theory Galton, Francis (1822 — 1911) Galvani, Luigi (1737 — 1798) galvanizing galvanometer game game theory GAMES AND PUZZLES gamete gametophyte Gamma (Soviet orbiting telescope) Gamma Cassiopeiae Gamma Cassiopeiae star gamma function gamma globulin gamma rays Gamma Velorum gamma - ray burst gamma - ray satellites Gamow, George (1904 — 1968) ganglion gangrene Ganswindt, Hermann (1856 — 1934) Ganymede «garbage theory», of the origin of life Gardner, Martin (1914 — 2010) Garneau, Marc (1949 ---RRB- garnet Garnet Star (Mu Cephei) Garnet Star Nebula (IC 1396) garnierite Garriott, Owen K. (1930 ---RRB- Garuda gas gas chromatography gas constant gas giant gas laws gas - bounded nebula gaseous nebula gaseous propellant gaseous - propellant rocket engine gasoline Gaspra (minor planet 951) Gassendi, Pierre (1592 — 1655) gastric juice gastrin gastrocnemius gastroenteritis gastrointestinal tract gastropod gastrulation Gatewood, George D. (1940 ---RRB- Gauer - Henry reflex gauge boson gauge theory gauss (unit) Gauss, Carl Friedrich (1777 — 1855) Gaussian distribution Gay - Lussac, Joseph Louis (1778 — 1850) GCOM (Global Change Observing Mission) Geber (c. 720 — 815) gegenschein Geiger, Hans Wilhelm (1882 — 1945) Geiger - Müller counter Giessler tube gel gelatin Gelfond's theorem Gell - Mann, Murray (1929 ---RRB- GEM «gemination,» of martian canals Geminga Gemini (constellation) Gemini Observatory Gemini Project Gemini - Titan II gemstone gene gene expression gene mapping gene pool gene therapy gene transfer General Catalogue of Variable Stars (GCVS) general precession general theory of relativity generation ship generator Genesis (inflatable orbiting module) Genesis (sample return probe) genetic code genetic counseling genetic disorder genetic drift genetic engineering genetic marker genetic material genetic pool genetic recombination genetics GENETICS AND HEREDITY Geneva Extrasolar Planet Search Program genome genome, interstellar transmission of genotype gentian violet genus geoboard geode geodesic geodesy geodesy satellites geodetic precession Geographos (minor planet 1620) geography GEOGRAPHY Geo - IK geologic time geology GEOLOGY AND PLANETARY SCIENCE geomagnetic field geomagnetic storm geometric mean geometric sequence geometry GEOMETRY geometry puzzles geophysics GEOS (Geodetic Earth Orbiting Satellite) Geosat geostationary orbit geosynchronous orbit geosynchronous / geostationary transfer orbit (GTO) geosyncline Geotail (satellite) geotropism germ germ cells Germain, Sophie (1776 — 1831) German Rocket Society germanium germination Gesner, Konrad von (1516 — 1565) gestation Get Off the Earth puzzle Gettier problem geyser g - force GFO (Geosat Follow - On) GFZ - 1 (GeoForschungsZentrum) ghost crater Ghost Head Nebula (NGC 2080) ghost image Ghost of Jupiter (NGC 3242) Giacconi, Riccardo (1931 ---RRB- Giacobini - Zinner, Comet (Comet 21P /) Giaever, Ivar (1929 ---RRB- giant branch Giant Magellan Telescope giant molecular cloud giant planet giant star Giant's Causeway Giauque, William Francis (1895 — 1982) gibberellins Gibbs, Josiah Willard (1839 — 1903) Gibbs free energy Gibson, Edward G. (1936 ---RRB- Gilbert, William (1544 — 1603) gilbert (unit) Gilbreath's conjecture gilding gill gill (unit) Gilruth, Robert R. (1913 — 2000) gilsonite gimbal Ginga ginkgo Giotto (ESA Halley probe) GIRD (Gruppa Isutcheniya Reaktivnovo Dvisheniya) girder glacial drift glacial groove glacier gland Glaser, Donald Arthur (1926 — 2013) Glashow, Sheldon (1932 ---RRB- glass GLAST (Gamma - ray Large Area Space Telescope) Glauber, Johann Rudolf (1607 — 1670) glaucoma glauconite Glenn, John Herschel, Jr. (1921 ---RRB- Glenn Research Center Glennan, T (homas) Keith (1905 — 1995) glenoid cavity glia glial cell glider Gliese 229B Gliese 581 Gliese 67 (HD 10307, HIP 7918) Gliese 710 (HD 168442, HIP 89825) Gliese 86 Gliese 876 Gliese Catalogue glioma glissette glitch Global Astrometric Interferometer for Astrophysics (GAIA) Global Oscillation Network Group (GONG) Globalstar globe Globigerina globular cluster globular proteins globule globulin globus pallidus GLOMR (Global Low Orbiting Message Relay) GLONASS (Global Navigation Satellite System) glossopharyngeal nerve Gloster E. 28/39 glottis glow - worm glucagon glucocorticoid glucose glucoside gluon Glushko, Valentin Petrovitch (1908 — 1989) glutamic acid glutamine gluten gluteus maximus glycerol glycine glycogen glycol glycolysis glycoprotein glycosidic bond glycosuria glyoxysome GMS (Geosynchronous Meteorological Satellite) GMT (Greenwich Mean Time) Gnathostomata gneiss Go Go, No - go goblet cell GOCE (Gravity field and steady - state Ocean Circulation Explorer) God Goddard, Robert Hutchings (1882 — 1945) Goddard Institute for Space Studies Goddard Space Flight Center Gödel, Kurt (1906 — 1978) Gödel universe Godwin, Francis (1562 — 1633) GOES (Geostationary Operational Environmental Satellite) goethite goiter gold Gold, Thomas (1920 — 2004) Goldbach conjecture golden ratio (phi) Goldin, Daniel Saul (1940 ---RRB- gold - leaf electroscope Goldstone Tracking Facility Golgi, Camillo (1844 — 1926) Golgi apparatus Golomb, Solomon W. (1932 — 2016) golygon GOMS (Geostationary Operational Meteorological Satellite) gonad gonadotrophin - releasing hormone gonadotrophins Gondwanaland Gonets goniatite goniometer gonorrhea Goodricke, John (1764 — 1786) googol Gordian Knot Gordon, Richard Francis, Jr. (1929 — 2017) Gore, John Ellard (1845 — 1910) gorge gorilla Gorizont Gott loop Goudsmit, Samuel Abraham (1902 — 1978) Gould, Benjamin Apthorp (1824 — 1896) Gould, Stephen Jay (1941 — 2002) Gould Belt gout governor GPS (Global Positioning System) Graaf, Regnier de (1641 — 1673) Graafian follicle GRAB graben GRACE (Gravity Recovery and Climate Experiment) graceful graph gradient Graham, Ronald (1935 ---RRB- Graham, Thomas (1805 — 1869) Graham's law of diffusion Graham's number GRAIL (Gravity Recovery and Interior Laboratory) grain (cereal) grain (unit) gram gram - atom Gramme, Zénobe Théophile (1826 — 1901) gramophone Gram's stain Gran Telescopio Canarias (GTC) Granat Grand Tour grand unified theory (GUT) Grandfather Paradox Granit, Ragnar Arthur (1900 — 1991) granite granulation granule granulocyte graph graph theory graphene graphite GRAPHS AND GRAPH THEORY graptolite grass grassland gravel graveyard orbit gravimeter gravimetric analysis Gravitational Biology Facility gravitational collapse gravitational constant (G) gravitational instability gravitational lens gravitational life gravitational lock gravitational microlensing GRAVITATIONAL PHYSICS gravitational slingshot effect gravitational waves graviton gravity gravity gradient gravity gradient stabilization Gravity Probe A Gravity Probe B gravity - assist gray (Gy) gray goo gray matter grazing - incidence telescope Great Annihilator Great Attractor great circle Great Comets Great Hercules Cluster (M13, NGC 6205) Great Monad Great Observatories Great Red Spot Great Rift (in Milky Way) Great Rift Valley Great Square of Pegasus Great Wall greater omentum greatest elongation Green, George (1793 — 1841) Green, Nathaniel E. Green, Thomas Hill (1836 — 1882) green algae Green Bank Green Bank conference (1961) Green Bank Telescope green flash greenhouse effect greenhouse gases Green's theorem Greg, Percy (1836 — 1889) Gregorian calendar Grelling's paradox Griffith, George (1857 — 1906) Griffith Observatory Grignard, François Auguste Victor (1871 — 1935) Grignard reagent grike Grimaldi, Francesco Maria (1618 — 1663) Grissom, Virgil (1926 — 1967) grit gritstone Groom Lake Groombridge 34 Groombridge Catalogue gross ground, electrical ground state ground - track group group theory GROUPS AND GROUP THEORY growing season growth growth hormone growth hormone - releasing hormone growth plate Grudge, Project Gruithuisen, Franz von Paula (1774 — 1852) Grus (constellation) Grus Quartet (NGC 7552, NGC 7582, NGC 7590, and NGC 7599) GSLV (Geosynchronous Satellite Launch Vehicle) g - suit G - type asteroid Guericke, Otto von (1602 — 1686) guanine Guiana Space Centre guidance, inertial Guide Star Catalog (GSC) guided missile guided missiles, postwar development Guillaume, Charles Édouard (1861 — 1938) Gulf Stream (ocean current) Gulfstream (jet plane) Gullstrand, Allvar (1862 — 1930) gum Gum Nebula gun metal gunpowder Gurwin Gusev Crater gut Gutenberg, Johann (c. 1400 — 1468) Guy, Richard Kenneth (1916 ---RRB- guyot Guzman Prize gymnosperm gynecology gynoecium gypsum gyrocompass gyrofrequency gyropilot gyroscope gyrostabilizer Gyulbudagian's Nebula (HH215)

Design of association studies with pooled or un ‐ pooled next ‐ generation sequencing data Kim, S. Y., Y. Li, Y. Guo, R. Li et al. 2010.

Committee Work and Service: Professional: Faculty member of the CSHL Infrastructure and Training to Bring Next - generation Sequence (NGS) Analysis Into Undergraduate Education; Diversity committees for the Society for the Study of Reproduction (SSR) and American Society of Andrology; Phi Kappa Phi, Sigma Xi Scientific Research Society (vice-president and co-chair student research funding with Mary Shaw), Reviewer for a variety of scientific journals (Lab Animal, Andrology, Asian J Andrology, Reproduction, Cell and Tissue Research).

Methodology challenges in studying human gut microbiota — effects of collection, storage, DNA extraction and next generation sequencing technologies — Marina Panek — Scientific Reports

In the case of clinical next - generation sequencing, and in genetic cohort studies and biobanks, pertinent issues include the interpretation of data, data storage, data sharing, informed consent and identifiability / privacy [20][26].

In fact, this study reports the largest scale use of massively parallel genomic sequencing (so called next generation sequencing) for medical diagnostics to date and shows that it is practically feasible on a large scale.

In a study being published online today in the journal Cell, researchers in the laboratory of Gladstone Senior Investigator Benoit Bruneau, PhD, employed stem cell technology, next - generation DNA sequencing and computing tools to piece together the instruction manual, or «genomic blueprint» for how a heart becomes a heart.

Metagenomics: Tools and Insights for Analyzing Next - Generation Sequencing Data Derived from Biodiversity Studies — Anastasis Oulas — Bioinform Biol Insights — May 2015

Next - Generation Sequencing of the Bacterial 16S rRNA Gene for Forensic Soil Comparison: A Feasibility Study — Ellen M. Jesmok — Journal of Forensic Sciences — February 2016

Very recently, a rather limited number of retrospective studies, utilizing whole genome sequencing (Talkowski et al., 2012) or whole exome sequencing (WES) in small cohorts of neonates and aborted fetuses with various ultrasound and / or post-mortem structural abnormalities (Carss et al., 2014; Drury et al., 2015; Alamillo et al., 2015; Westerfield et al., 2015), provided initial proof - of - principle of large - scale prenatal next generation sequencing (NGS).

Ongoing T2D research activities at CRGGH include 1) whole - exome sequencing of African families with at least four affected members (data generation is complete and analysis is ongoing), 2) GWAS of 1,200 cases and 1,200 controls from West Africa using the new and more efficient African - centric Affymetrix Axiom genome - wide array with more than 2 million markers, and 3) whole genome expression analysis on skeletal muscle obtained from biopsy from 45 subjects (expression QTL (eQTL) studies on the dataset are complete).

In this study, we sequenced the whole genome of DNA in whole blood of two pairs of monozygotic (MZ) twins, 40 and 100 years old, by two independent next - generation sequencing (NGS) platforms.

Follow - up of these studies, including work on long and short non-coding RNA and whole - exome sequencing, are performed using next - generation sequencing technology.

Cell tracking and manipulation in genetically modified mice 2015-03-31 Presentation 06 Fafilek Mouse transgenic model to study tumor progression and metastasis in the gut 2015-03-24 Presentation 05 Krausova Next generation sequencing: designing experiment in transgenic

Group - based variant calling leveraging next - generation supercomputing for large - scale whole - genome sequencing studies.

The MRC Centre for Genomics and Global Health (CGGH) and the MRC Unit in The Gambia are working in partnership to generate genome sequence data on 500 individuals sampled across different ethnic groups that will underpin the next generation of studies into the causes and prevention of common diseases in West Africa.

His talk covered three very different applications of next - generation sequencing: high - throughput mutational studies of core promoters, sub-assembly of Illumina reads to 454 - length contigs, and exome capture to unravel Mendelian disorders.

A study by Pauli and colleagues in this issue of Cancer Discovery describes the creation of a precision cancer platform for patients with advanced disease, integrating DNA sequencing of patient tumors with the generation of patient - derived organoids and xenografts.

Next - generation association studies can be empowered by sequence - based imputation and by studying founder populations.

In this study, we have examined the differences between the four commonly used whole genome next - generation sequencing platforms, Illumina's HiSeq2000, Life Technologies» SOLiD 4 and 5500xl SOLiD, and Complete Genomics» technology.

Second - generation sequencing technologies transformed the study of microbial transcriptomes.

On the study of microbial transcriptomes using second - and third - generation sequencing technologies

Oryza coarctata plants, collected from Sundarban delta of West Bengal, India, have been used in the present study to generate draft genome sequences, employing the hybrid genome assembly with Illumina reads and third generation Oxford Nanopore sequencing technology.

«In this study we applied the method to bacterial 16S sequencing but since the generation of these libraries is easy, flexible and cost effective — no fancy fluidics equipment or chemical synthesis of specific barcodes is needed — we are currently applying the assay in a number of other projects.

Metagenomics is the study of the sequences of large populations of different organisms all growing in a common environment - as for example seawater, soil, the human gut - and these studies are made vastly easier by next - generation sequencing.

Any Dog Club or individual wishing to fund the generation and analysis of a whole genome sequence to study a particular heritable disease or to provide a normal reference sequence for a particular breed should contact Gary Johnson at This email address is being protected from spambots.