Sentences with phrase «generation sequencing technologies in»

His current research activities include the implementation of next generation sequencing technologies in a diagnostic setting and the use of this technology to better understand cancer etiology and treatment.

Not exact matches

The test — which currently costs $ 99.95 but originally was $ 199.95 — is different from AncestryDNA and 23andMe in that it uses next - generation sequencing instead of genotyping technology.

The researchers used next generation sequencing technology, RNA sequencing, to reveal «in exquisite detail» the blueprint for making milk in the human mammary gland, according to Laurie Nommsen - Rivers, PhD, RD, IBCLC, a scientist at Cincinnati Children's and corresponding author of the study, published online in PLOS ONE, a journal of the Public Library of Science.

From Sewers to Streetlights, Microbes Are Grabbing Civil Engineers» Attention An understanding of how to cultivate a healthy «microbiome» in our living areas is now getting off the ground, boosted by next - generation DNA sequencing technologies.

Using next - generation sequencing technologies that were previously unavailable, Michael Gardner, a graduate research assistant, and Jianying Wang, a senior research associate in Mitchum's lab, made a remarkable new discovery — nematodes possess the ability to produce a second type of peptide that can effectively «take over» plant stem cells that are used to create vital pathways for the delivery of nutrients throughout the plant.

Using next - generation RNA sequencing and other advanced technologies, the researchers identified a previously unknown gene involved in betalain synthesis and revealed which biochemical reactions plants use to convert the amino acid tyrosine into betalains.

A University of Colorado Cancer Center study published in the journal Oncogene used next - generation sequencing technologies to perform the most detailed DNA - based analysis to date of 25 commonly used bladder cancer cell lines, allowing researchers to match patient tumors with their closest genetic cell line match, and demonstrated genetic alterations that may make cells more or less sensitive to common therapies.

With recent, rapid advances in next - generation sequencing technologies, large genomic data sets are becoming increasingly obtainable.

«Next - generation sequencing technology has allowed us to find new causes of genetic diseases in much smaller families,» explained the study's lead author, William Motley, MD, PhD, a resident physician in Medicine.

Among these is BRG1 (also called SMARCA4) and the latest generation - sequencing technologies have extended these findings to other tumor types evidencing that BRG1 inactivation is widespread in cancer.

Genome researcher Elaine Mardis of Washington University in St. Louis in Missouri cautions that because the 1000 Genomes Project participants» genomes weren't sequenced in depth and were done when next - generation sequencing technologies were very new, MacArthur's team may have missed some loss - of - function variants.

In loblolly pine, these were first generated with > 300,000 Sanger - sequenced expressed sequence tags (ESTs) and later as de novo assemblies from next - generation sequencing technologies (Allona et al. 1998; Kirst et al. 2003; Cairney et al. 2006; Lorenz et al. 2006, 2012).

This short course will discuss the current state of PGS and PGD, latest advances in technologies such as next - generation sequencing, and the challenges we face with mosaic embryos.

Methodology challenges in studying human gut microbiota — effects of collection, storage, DNA extraction and next generation sequencing technologies — Marina Panek — Scientific Reports

Moreover, we demonstrated that although the Oxford Nanopore technology is a relatively new sequencing technology, currently with a high error rate, it is already useful in the generation of high - quality genome assemblies.

These technologies include next generation exome and whole - genome sequencing, ChiP - sequencing, tissue transcriptome and epitope profiling, and miRNome, proteome and metabolome screening in different body fluids.

Therefore, I am engaged in using, developing and combining new technologies, including: (1) super-resolution microscopy, (2) single molecule imaging, (3) genetic engineering, (4) next generation sequencing approaches and (5) mathematical and biophysical modeling.

In a study being published online today in the journal Cell, researchers in the laboratory of Gladstone Senior Investigator Benoit Bruneau, PhD, employed stem cell technology, next - generation DNA sequencing and computing tools to piece together the instruction manual, or «genomic blueprint» for how a heart becomes a hearIn a study being published online today in the journal Cell, researchers in the laboratory of Gladstone Senior Investigator Benoit Bruneau, PhD, employed stem cell technology, next - generation DNA sequencing and computing tools to piece together the instruction manual, or «genomic blueprint» for how a heart becomes a hearin the journal Cell, researchers in the laboratory of Gladstone Senior Investigator Benoit Bruneau, PhD, employed stem cell technology, next - generation DNA sequencing and computing tools to piece together the instruction manual, or «genomic blueprint» for how a heart becomes a hearin the laboratory of Gladstone Senior Investigator Benoit Bruneau, PhD, employed stem cell technology, next - generation DNA sequencing and computing tools to piece together the instruction manual, or «genomic blueprint» for how a heart becomes a heart.

Developed in collaboration with the Laboratory Medicine, Information Technology and Health Science Research departments of Mayo Clinic Geneticist Assistant NGS Interpretative Workbench, is a web - based tool for the control, visualization, interpretation and historical knowledge base of next generation sequencing data targeted at specific genes for the purpose of identifying potentially pathogenic variants associated with specific conditions such as hereditary colon cancer.

Sanger sequencing methods represent the most popular in a range of «first - generation» nucleic acid sequencing technologies.

There have been tremendous advances in genetic technology, next - generation sequencing, and also, high - throughput methods to genotype patients, and get genetic information.

Bertout proposes to use new barcoding technologies she developed in the Bielas Lab to build upon Next Generation Sequencing technologies and enable exquisitely sensitive cancer - specific mutation detection.

The experiments relied on innovative uses of next - generation DNA sequencing technologies, which had only become available around five years ago, due in large part to advances enabled by NHGRI's DNA sequencing technology development program.

This unique technology was launched in December 2017, and integrates automated chromatin immunoprecipitation and next generation sequencing library preparation within the same protocol, eliminating the traditional tedious steps, purifications, and inefficiencies that can result from standard ChIP - seq protocols.

Next - generation sequencing technologies are said to be ushering in a new era of cancer genomics.

This is due in large part to the maturation of so - called next - generation sequencing technology, which allows the DNA of the entire genome to be sequenced far less expensively and with far greater accuracy than ever before.

I am also active in applying next - generation sequencing technology to identify specific genomic changes in cancers that can be therapeutically targeted.

We report a third - generation sequencing assay on nanopore technology (MinION) for detecting BCR - ABL1 KD mutations and compare the results to a Sanger sequencing (SS)- based test in 24 Philadelphia - positive (Ph +) leukemia cases.

The advent of next - generation technologies has fuelled an explosion in the quantity of raw DNA sequence that can be generated by a reasonably sized genomics facility.

The recent developments in high throughput single - cell RNA sequencing technology (scRNA - seq) have enabled the generation of vast amounts of transcriptomic data at cellular resolution.

Next - generation sequencing (NGS) technologies have driven recent progress in these areas.

In this study, we have examined the differences between the four commonly used whole genome next - generation sequencing platforms, Illumina's HiSeq2000, Life Technologies» SOLiD 4 and 5500xl SOLiD, and Complete Genomics» technology.

Oryza coarctata plants, collected from Sundarban delta of West Bengal, India, have been used in the present study to generate draft genome sequences, employing the hybrid genome assembly with Illumina reads and third generation Oxford Nanopore sequencing technology.

Next generation sequencing is cutting - edge technology that has only been available in the last 10 years.

While the physical and digital are frequently used in opposition, the linguistic use of biological terms in technology — where software and the body are spoken about in terms of generations and viruses — underlie conceptual relationships of sequence and variation, both desirable and detrimental.

As an independent research scientist with in vivo and in vitro experience in basic and translational research, I have equipped with in - depth knowledge of current state - of - art technologies, including next - generation sequencing, CGH analysis and RNAseq.

Proficient in applying conventional and next generation sequencing technology for viral quasispecies characterization.