Sentences with phrase «genes affect neurons»

The researchers plan to investigate what percentage of individuals individuals with intellectual disability and autism may carry CC2D1A mutations and to determine whether other genes affect neurons in a similar fashion.

Not exact matches

When looking into mechanisms that might affect the levels of SMN protein in neurons, the researchers scanned a genomic database called the UCSC Genome Browser and identified two genetic sequences that matched the opposite DNA strand of the SMN gene.

In individuals affected by SMA, the survival motor neuron - 1 (SMN1) gene is mutated and lacks the ability to process a key protein that helps neurons function.

The goal of early SMA drug discovery programs has been to identify small molecules that induce the SMN gene to produce sufficient levels of protein to improve motor neuron functioning in affected patients.

Other directions for future research, Liu said, include looking at the role of CLOCK in more forms of the disease, learning more about exactly how CLOCK affects neural circuits to disrupt adequate inhibition of excitatory neurons, and examining whether any of the genes that CLOCK regulates are especially important in the disorder.

In individuals affected by SMA, the spinal motor neuron - 1 (SMN1) gene is mutated and lacks the ability to process a key protein that helps muscle neurons function.

To understand why only some motor neurons are vulnerable to ALS, the researchers used DNA microarray profiling to compare the activity of tens of thousands of genes in neurons that resist ALS (oculomotor neurons / eye movement and Onuf's nuclei / continence) with neurons affected by ALS (lumbar 5 spinal neurons / leg movement).

So even though the genes that cause ALS and SMA are different, they might share a common pathway that affects motor neuron structure and function.»

Howard Hughes Medical Institute (HHMI) scientists have profiled key features of the genetic material inside three types of brain cells and found vast differences in the patterns of chemical modifications that affect how the genes in each type of neuron are regulated.

«We hope that in the future, by fully understanding how this gene affects signaling in the brain, we may be able to identify drugs to restore the normal signaling balance in neurons and improve cognitive and social function in patients,» says lead author Dr. M. Chiara Manzini.

Alsin's function isn't clear, but because the affected family members have two defective copies of the gene, called ALS2, the protein could play a role in motor neuron function.

To see how courting is affected when neurons are hyperactivated, they used flies with a version of a gene that was stuck in the «on» state in clumps of nerve cells.

A region of the gene that produces the PACAP38 protein has held nearly constant, even in humans, presumably because the protein plays diverse roles in neuron communication and is essential for normal development of the cerebellum, affecting brain cell migration, for example.

Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation.

Researchers had assumed that the SMA gene, essential for the survival of motor neurons, affected only that particular type of neuron.

It is located on the long arm of chromosome 15 in the LINGO1 gene, which encodes a protein that has been shown to affect how neurons are formed and signal each other.

Scientists at the Whitehead Institute used CRISPR / Cas9 gene editing method to restore activity to the fragile X syndrome gene in affected neurons.

By affecting the rate of cell differentiation and gene expression, thyroid hormones regulate the growth and migration of neurons, including synaptic development and myelin formation in specific brain regions.