Sentences with phrase «genes affect responses»

Pharmacogenomics — the study of how genes affect responses to drugs — is becoming more important in drug - development research and clinical trials, with a view toward decreasing side effects and increasing the efficiency and efficacy of drugs in patients with the right genetic profiles.

Somatic mutations of the CREBBP and EP300 genes affect response to histone deacetylase inhibition in malignant DLBCL clones

Not exact matches

«This is exciting because if genes affected differences between individuals in these traits, it means they could also change in response to natural selection,» said Dr Bolund.

In comparison with African strains, infection by the Asian strain of Zika virus more potently affected the p53 gene and genes connected with cells» responses to viral infection, such as interferons.

But he warns that the gene could have undesirable side effects in some plants: «If we indiscriminately make a plant insensitive to ethylene, we may affect its response to diseases or to pests.»

The results from the study also showed that genes that increase the risk for cancer and diabetes, or are important for the immune response or sperm quality, are affected by smoking.

More than a hundred sites in the genome showed strong evidence of recent selection, including genes that affect muscle tissue, hair, hearing, immune - system function, skin pigmentation, sense of smell, and the body's response to heat stress.

Functional analyses indicate that MFSD12 encodes a lysosomal protein that affects melanogenesis in zebrafish and mice, and that mutations in melanocyte - specific regulatory regions near DDB1 / TMEM138 correlate with expression of ultraviolet response genes under selection in Eurasians.

To figure out how corn and weeds affect each other's gene response, Clay and a team of two research associates and a soils expert, planted plots of velvetleaf alone, corn with velvetleaf and corn kept weed - free.

While the researchers emphasized the study sample was too small to draw firm conclusions, it appears yoga may modulate the body's epigenetic response, which turns certain genes on or off, affecting physical as well as mental health.

Because previous studies had suggested that different alleles (versions) of the IL - 28B gene affect immune responses, the researchers determined which alleles the transplant recipients carried.

Esparza stresses that no one really knows how the differences between the various subtypes — in the sequence of their env gene, and structure of their gp120 — will affect people's immune responses.

Utilizing genetic approaches such as «fine mapping» and «genome editing,» the researchers narrowed the region of the chromosome and targeted each gene to responsible for affecting the behavioral response to the drug.

We notably follow the time course of structural changes in response to cues that affect gene expression either transiently or permanently: changes in genome structure during transient hormonal response of differentiated cells and stable trans - differentiation of B cells to macrophages.

April 4, 2000 $ 11 - million grant supports study of how genes affect cancer chemotherapy NIGMS has awarded more than $ 11 million to a team of researchers based at the University of Chicago to investigate how genes influence the response to anti-cancer drugs.

His discoveries include insights into how changes in gene expression affect T cell exhaustion, a waning of immune function that occurs in response to chronic viral infection and cancer.

Among their work, the investigators are looking at how ROS affects gene regulatory responses in cells that are exposed to elevated glucose levels or other stimuli.

For those experiencing acute or chronic pain, this genetic test analyzes how your genes affect your body's response to FDA - approved opioids, NSAIDs and muscle relaxants to accurately determine which medications are optimal.

The Dockrell group is focusing on genes and cells that play a crucial role in polarisation of the immune responses and that could affect vaccine efficacy.

The most striking results were those showing that soybean oil significantly affects the expression of many genes that metabolize drugs and other foreign compounds that enter the body, suggesting that a soybean oil - enriched diet could affect one's response to drugs and environmental toxicants, if humans show the same response as mice.

The significance of detox becomes apparent when you understand that our main liver detox gene, P450, has been crippling by the industrial seed oils ubiquitous in the food system thus hindering our ability to detox; recent studies have found that soybean oil, canola oil (and vegetable oils as they typically contain soybean / canola oil) significantly affect the expression of many genes that metabolize drugs and other foreign compounds that enter the body, suggesting that a soybean oil - enriched diet could affect one's response to drugs and environmental toxicants.

Furthermore, many of the changes have affected the genes that dictate and regulate immune responses.

Two key genes were affected in the cellular response to decreased glucose consumption.

A number of other genes, including MAOA — the so - called «warrior gene», which affects neurotransmitters such as dopamine, norepi - nephrine and serotonin — have also been identified as undergoing methylation in response to early life adversity.