Sentences with phrase «genes affected by»

This approach and the threshold of 0.2 allows us to test our hypothesis that T cell DNA methylation is associated with aggression trajectory and to generate further hypotheses about the functions of genes affected by the associated methylation changes.

Many of the genes affected by the temperature treatment are also involved in important developmental processes (Long et al., 2012).

386/11: 15 Clinical indexing genes affected by copy number variation in neurodevelopmental disorders.

We found that an unusually high number of genes affected by these DNA deletions / duplications are associated with the functioning of synaptic transmission between nerve cells.

This may help identify genes affected by the epidemic — or those that now protect against infection.

In the associated paper, Vitkup, Iossifov and others use a novel form of analysis called NETBAG (network - based analysis of genetic associations) to identify «the large biological network of genes affected by rare de novo CNVs in autism.»

«The Medaka experiment finding of new genes affected by microgravity provides a good animal model to clarify this mechanism.»

In particular, the Neandertal genome sequence can now be used to catalog changes that have become «fixed» (are invariant within a population or species) in modern humans during the last few hundred thousand years and should be helpful for identifying genes affected by positive selection since humans diverged from Neandertals.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

A single miRNA can ramp down expression of multiple genes — but the number of genes affected by known miRNAs hasn't been determined.

These researchers say that there are hundreds of genes affected by nurturance.

By comparing the genome of these three variants, Di - Poï and Milinkovitch have discovered the gene affected by this mutation.

The team identified the gene affected by the mutation code for asparagine synthetase, the enzyme responsible for synthesizing the amino acid asparagine.

Mice in which a gene affected by Williams syndrome is experimentally deleted show increased separation anxiety.

Not exact matches

But what's really significant in the research is the identification of which genes are selectively affected by consumption of dietary fat or by capsaicin.

Parenting styles can be affected by both maternal and paternal genes in combination with the environment.

The scientists were interested in understanding what factors influenced women to share test results, particularly with their children, who might also be affected by the cancer - conferring genes.

These conditions are each caused by mutations in a particular gene, and affect different enzymes involved in breaking down galactose.

Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

The most common form of SMA is caused by mutation of the SMN gene, and manifests over a wide range of severity affecting infants through adults.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

In individuals affected by SMA, the survival motor neuron - 1 (SMN1) gene is mutated and lacks the ability to process a key protein that helps neurons function.

Genetic research could also enable fussy eaters to get all the nutrients they need by finding the genes that affect taste preference.

At best, the scientists say, there is a 50 - 50 chance that the gene closest to a mutation will even be active in the cell types affected by a disease.

GWAS identify regions of the genome that can contain hundreds of genes potentially affected by a mutation.

Examples of gene networks in the hippocampus affected by brain trauma.

The study, which is published in the journal Molecular Psychiatry, describes a possible mechanism for how the gene variant produces clinical symptoms by affecting levels of specific proteins in the brain.

This led Pembrey to suspect that genes on the sex - specific X and Y chromosomes were being affected by epigenetic signals.

Complex traits like the ones in the study are each influenced by many different genes, while at the same time, several different traits can be affected by the same genes.

Researchers then tested cell cultures and mouse models by using a gene editing process called CRISPR - Cas9 to demonstrate how the presence or absence of myomaker and myomerger — both individually and in unison — affect cell fusion and muscle formation.

Gene discovery was accomplished by only six PRA - affected dogs.

As Saaïd Safieddine, CNRS Director of Research at the Institut Pasteur and co-senior author of the study with Prof. Christine Petit (head of the Genetics & physiology hearing unit at the Institut Pasteur), explains, «we have just shown that it is possible to partially correct a specific form of hereditary hearing loss accompanied by balance problems using local gene therapy performed after the embryogenesis of the ear, which is primarily affected by the mutation responsible for the disorder.

But as some miRNAs regulate many different genes, and each gene is affected by many different miRNAs, their exact role in cancer is tough to pin down.

In comparison with African strains, infection by the Asian strain of Zika virus more potently affected the p53 gene and genes connected with cells» responses to viral infection, such as interferons.

Yang said the study not only indicated which genes are affected by traumatic brain injury and linked to serious disease, but also might point to the genes that govern metabolism, cell communication and inflammation — which might make them the best targets for new treatments for brain disorders.

Comparisons of the Neandertal genome to the genomes of five present - day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development.

By tracking activity in almost all the genes of a free - living archaeon — which, like a bacterium, is a prokaryote — Bonneau was recently able to piece together how the genes affected one another's expression, enabling him to map the organism's «control circuit» as if it were a machine.

Unlike other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single gene, based on analyses of affected families.

The answer may lie in epigenetics — the mechanism by which environmental influences affect gene expression.

In individuals affected by SMA, the spinal motor neuron - 1 (SMN1) gene is mutated and lacks the ability to process a key protein that helps muscle neurons function.

The new gene permanently switched on a set of genes normally affected by insulin and involved in the immune system.

However, Pafilis is puzzled by how it affects the males» chances of passing on their genes to the next generation.

The result was the largest deletion ever observed in the dystrophin gene using CRISPR / Cas9, and the study was the first to create corrected human iPS cells that could directly restore functional muscle tissue affected by Duchenne.

New evidence from animal studies supported by the National Institute of Mental Health suggests that a specific gene may affect learned fearfulness.

George Daley of Harvard Medical School said on December 1 that he and his team have seen multiple patients affected by NEMO deficiency syndrome, a disorder where an inherited faulty gene results in a weak immune system and leaves patients prone to serious infections.

The results from the study also showed that genes that increase the risk for cancer and diabetes, or are important for the immune response or sperm quality, are affected by smoking.

Later in life the genetic material can be changed by epigenetic modifications, i.e. chemical alterations of the DNA the affect the activity of the genes.

«The new FOP model already has shed light on the disease process in FOP by showing that the mutated gene can affect different steps of bone formation,» Hsiao said.

The tiny addition of a chemical mark atop a gene that is well known for its involvement in clinical depression and posttraumatic stress disorder can affect the way a person's brain responds to threats, according to a new study by Duke University researchers.

This analysis, done on separate samples from the same patient, revealed that many of the affected genes confer advantages to cancer cells by, for example, enhancing cell migration or resistance to chemotherapy.