Sentences with phrase «genes associated with disease in»

We will also look for genes associated with the disease in Old English Sheepdogs and Cocker Spaniels, since these breeds are especially prone to ITP.

We also plan to look for genes associated with the disease in Old English Sheepdogs (OES) and Cocker Spaniels (CS), since these breeds are especially prone to ITP.

The similarity of the mouse and human genetic make - up means that genes associated with disease in humans can be studied and further investigated in mouse models.

A new national collaboration of asthma genetics researchers has revealed a novel gene associated with the disease in African - Americans, according to a new scientific report.

July 31, 2011 National asthma genetics consortium releases first results A new national collaboration of asthma genetics researchers has revealed a novel gene associated with the disease in African - Americans, according to a new scientific report.

Purpose: Many current studies are aimed at trying to identify genes associated with diseases in dogs, but we are looking to see if there might exist «protective genes» that could help protect against these same life - limiting diseases in the dog.

Not exact matches

In 2015, the viral «Ice Bucket Challenge» helped fund groundbreaking research that led to the discovery of a gene associated with the disease.

Collaboration based on new findings from the Regeneron Genetics Center ® showing variant in HSD17B13 gene is associated with reduced risk of chronic liver diseases

One - third of yeast genes have counterparts in the human genome, many of which are associated with diseases, such as cancer.

The study identified yet another mutation — albeit a rare one — in the SCARB1 gene, also associated with elevated HDL levels, that raised coronary heart disease risk by a whopping 80 percent.

They chose Niemann - Pick Type C, a lysosomal storage disease associated with mutations in two ancient genes that are well - conserved in many organisms.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Interestingly, as many as nine of the genes have been previously associated with some vascular disease and four more are known to be involved in the regulation of vascular tone, supporting the importance of blood vessels in migraine attacks.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

Cases associated with changes in each of the four genes were different from each other in terms of symptoms, intelligence level and other disease features.

Meanwhile, the gene - rich X is the most intensely studied of the 23 chromosomes, largely because of its role in rendering men vulnerable to an estimated 300 genetic diseases and disorders associated with those mutations — from color blindness to muscular dystrophy to more than 200 brain disorders.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

Although there are several ways to remove RB from the cellular machinery, the group found that complete loss, rather than inactivation, of the RB gene was associated with changes in gene - networks closely linked to aggressive disease.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

In addition to speeding up the development of brain plaques associated with Alzheimer's, a gene variant known as APOE4 also makes tau tangles — another signature of the disease — worse, researchers report online September 20 in NaturIn addition to speeding up the development of brain plaques associated with Alzheimer's, a gene variant known as APOE4 also makes tau tangles — another signature of the disease — worse, researchers report online September 20 in Naturin Nature.

«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.

«With more than 1.7 million people dying globally from TB each year and the rise of strains that are resistant to drug treatment, we need a better way to prevent this disease,» said the study's principal investigator Louis Picker, M.D., who is the associate director of the OHSU Vaccine and Gene Therapy Institute and a professor of pathology, molecular microbiology, and immunology in the OHSU School of Medicine.

Although that marker, called IL21, had not previously been associated with autoimmune diseases, the gene that produces it sits right in the stretch of DNA known to make these mice vulnerable to diabetes, suggesting that IL21 might make a drug target, says Sarvetnick.Furthermore, by giving the animals a shot of dead bacteria — similar to an immunization in humans — when they were newborns, Sarvetnick and her colleagues prevented a surfeit of CD4 + and CD8 + cells.

In theory, this could allow researchers to, say, cripple or replace many parts of genes associated with human disease that CRISPR currently can not touch.

These products are designed to alter the expression of target genes in the body, suppressing expression of genes associated with disease, or restoring expression of genes required for health.

«For instance, the gene YWHAZ, involved in neuronal migration and plasticity, is associated with other diseases such as schizophrenia,» explains Cormand.

After his team first observed hair loss in Treg - deficient mice, Rosenblum learned that the genes associated with alopecia in previous studies are almost all related to Tregs, and treatments that boost Treg function have been shown to be an effective treatment for the disease.

Their findings, which appear in the August 2016 issue of the Journal of the American Chemical Society underscore the importance of looking at genes and proteins not classically associated with Alzheimer's to make progress in understanding the disease.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

The new finding is the latest evidence supporting a growing precision medicine model of psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple psychiatric disorders, with other genetic or epigenetic drivers, random developmental events, or environmental influences determining the specific disease an individual develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.

However, most disease genes discovered in the past decade indicate only an elevated risk, not a certainty, of developing the disorders with which they are associated, including cancer, diabetes, and heart disease.

Harris cited other examples of concern — a review of 100 studies in the field of psychology in which the findings in only about a third of the studies were reproducible; an effort by scientists at Bayer, another large drug company, that managed to reproduce the findings of only one - quarter of the studies under review; a just - published review of 25 historical candidate genes for schizophrenia which found no evidence that the candidate genes are more associated with the disease than other genes.

With her expertise in handling large genetic datasets, Dr Knight helped identify the two gene variants associated with improved responses to rasagiline in early Parkinson disease (With her expertise in handling large genetic datasets, Dr Knight helped identify the two gene variants associated with improved responses to rasagiline in early Parkinson disease (with improved responses to rasagiline in early Parkinson disease (PD).

Silencing of one of the «cell death» genes may be the first step in finding treatments to help woman delay menopause or avoid the health problems — osteoporosis, heart disease — associated with the cessation of estrogen production.

To help in his hunt for disease genes, Pe'er founded The Ashkenazi Genome Consortium (TAGC) in September 2011 with Todd Lencz, an investigator at The Feinstein Institute for Medical Research, director of the Laboratory of Analytic Genomics at the Zucker Hillside Hospital, and associate professor of molecular medicine and psychiatry at the Hofstra North Shore - LIJ School of Medicine.

Researchers studying two generations of a family affected by pediatric acute lymphoblastic leukemia (ALL) have identified an inherited variation in the ETV6 gene that is associated with an increased risk of developing the disease.

Former smokers showed more activity than nonsmokers in 124 genes, including several associated with lung disease — despite having quit up to 32 years earlier.

A decade ago, they also identified a relationship between ALS and excess iron accumulation when they found that 30 percent of ALS patients in their clinic carried a variant of a gene known as HFE that is associated with iron overload disease.

Indeed, nine of the 16 most distinctive genes are ones that in humans are associated with heart disease, Willerslev says.

«As the gene loci that had previously been associated with DLB were also implicated in Alzheimer's and Parkinson's, it was unclear if DLB's genetic roots were simply a combination of the other two diseases.

Scientists have known for a few years that a mutation in a gene coding for the protein troponin T is associated with the disease.

Other genetic defects associated with hypertrophic cardiomyopathy — six different genes have been linked to the disease — may work similarly by producing abnormal proteins involved in contraction, says Sweeney.

One of their findings was a variant in a gene called Ret that had not been previously associated with the disease, although other variations in Ret had been fingered as culprits.

Case studies described in the article show how microRNAs may affect voluntary alcohol consumption in mice, candidate genes within signaling pathways associated with chronic obstructive pulmonary disease, and the microRNA: gene interactions that influence bladder cancer.

Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), both of which are caused by a mutation in the a gene called C9ORF72.

With that, investigators say the alterations in the ERBB2 gene strongly associate with pleomorphic lobular breast cancer but not the classic form of the diseWith that, investigators say the alterations in the ERBB2 gene strongly associate with pleomorphic lobular breast cancer but not the classic form of the disewith pleomorphic lobular breast cancer but not the classic form of the disease.

Thirty - four genes are associated with disease in humans.

Despite dozens of regions in the genome associated with CAD, most of the genetic components of heart disease are not fully understood, suggesting that more genes are out there to be found.

«Given the fact that genomic analysis is becoming more common in patients with a personal or family history of cancer, we have an opportunity to do more targeted breast cancer screening in women who carry any of the genes associated with risk for this disease.»