Sentences with phrase «genes by importance»

«Cells rank genes by importance to protect them, according to new research.»

Not exact matches

However, this first phase fairly rapidly was superseded by a second, in which Sewall Wright and Theodosius Dobzhansky were the two key figures, both of them insisting on the importance of thinking of populations of many genes, as well as populations of many individuals.

The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.

Despite setbacks in targeting mutant Ras genes, the National Cancer Institute (NCI) recently emphasized the continued importance of this elusive drug target by announcing a focused $ 10 million effort, dubbed the RAS project, to bring together researchers to develop new ideas for blocking Ras.

But you asked me right, the importance of gene duplication; most — I say, most, [which] is a rough number — but a very large number of the genes that carry out functions in our body are parts of [the] family of the genes, members of [the] family of the genes that have expanded by gene duplication.

But Ziv Bar - Joseph, an associate professor in the Machine Learning Department and the Lane Center for Computational Biology, said that view of what is essential and what isn't reflects how scientists study genes — by noting their effects on an organism when a gene is removed — not necessarily the gene's importance.

The study supports the importance of the serotonin which is specified and maintained by a specific gene, the Pet - 1 gene — for normal functioning of the neurons, synapses and networks in the cortex, as well as proper development of brain circuitry.

Rao and her team hope that pinpointing the importance of this trafficking mechanism in autism spectrum disorders may lead to the development of new drugs for autism that alter endosomal pH. As the use of genomic data becomes increasingly commonplace in the future, the step-wise strategy devised by her team can be used to screen gene variants and identify at - risk patients, she says.

On Supplementary Fig. 36c, we show the number of most informative genes (defined as the union of genes with importance > = 0.1 across all the 13 models in the case of the gene expression model, and the union of the genes with importance > = 0.1 across the 3 models in the case of TIN, with «importance» being a measure computed by xgboost) with respect to each tissue and data type.

The authors highlight the importance of measuring the variability of transcript expression and location in so many cells by using their data to discover genes with related functions in the cell.

Having confirmed that the miR - 181a target genes were expressed in these cultures, we next examined the functional importance of the BMP / GDF receptor - regulated Smads, Smad1 and Smad5, for the neurite growth induced by BMP / GDF ligands.

Recognizing the potential implications of a general method of altering the traits of entire populations, Kevin and colleagues have detailed ways to control, block, or even reverse changes made by gene drives and emphasized the importance of careful evaluation and regulatory reform.

Their importance is further emphasized by their ability to move larger regions of genetic material containing arrays of resistance genes.

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.