Sentences with phrase «genes cause»

(At this point we do not know what genes cause the remainder.)

Determining how candidate genes cause PLE would greatly facilitate the development of more effective treatments.

Since all dogs with CEA have CH it can be managed in the same way one would manage any single gene recessive trait even though other as - yet unidentified genes cause the more serious defects.

Unfortunately, we don't know which genes cause seizures.

The question of whether genes cause acne is one of the most important there is.

Why does bad FUT genes cause this problem?

If you are like me, you were raised with the notion (likely told by your dentist) that sugar and bad genes cause tooth decay and that if you were getting tooth decay as a child, you needed to cut back on sugar.

These regions may contain genes that increase the risk of depression, said the researchers, although the study does not prove these genes cause depression.

Then, I joined Benoit Bruneau's lab at Gladstone to study how genes control the process of heart development and how abnormalities in these genes cause congenital heart diseases.

Germline aberrations in critical DNA - repair and DNA damage - response (DDR) genes cause cancer predisposition, whereas various tumors harbor somatic mutations causing defective DDR / DNA repair.

Mutations that impair, or turn off, tumor suppressor genes cause an increased risk of developing cancer.

We plan to extend this discovery by developing a model of TBK1 glaucoma that will facilitate studies of the basic mechanisms by which defects in genes cause the disease.

Krogan believes that mutations in a few key networks of genes cause diseases like cancer, even though the individual genes that are mutated in tumors vary between different people and different types of cancer.

Previous reports have shown that in a genetic abnormality called Philadelphia chromosome, fusion of ABL and BCR genes cause leukemia.

The two genes each cause a form of non-insulin dependent diabetes (NIDDM) known as maturity - onset diabetes of the young (MODY).

«Learning more about how different genes cause cells to become and remain pluripotent will help us to produce and use stem cells more reliably.»

Do combinatorial human mutations / polymorphisms in cardiac developmental genes cause predisposition to disease?

Rare mutations in the NMDA receptor genes cause epilepsy (GRIN2A) or intellectual disability (GRIN2B).

However, the combined effects of many different genes cause most variation among individuals.

There are at least six genes that look to be under positive selection in cats that are associated with hearing capacity; we know this because mutations in these genes cause nonsyndromic recessive hearing loss or deafness.

The markers allow design of downstream functional experiments to investigate which genes cause the structure and which are a consequence of the structure.

Over the past decade, several dozen genes have been identified as potential culprits, and scientists believe that several genes cause disruptions in protein formations predisposing a person to schizophrenia.

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

Their lab helped reveal how faulty genes cause cancer, but Bert Vogelstein and Kenneth Kinzler sometimes irk colleagues with their «reality check» comments on genomic medicine.

Made of long strings of DNA (deoxyribonucleic acid), genes cause proteins to be manufactured, and then proteins run the body.

Mutations in mitochondrial genes cause a range of disorders, some mild and others life - threatening.

«Right now we have a lot of information on what changes in what genes cause what changes in form.

Because different mutations in the same gene caused the three behaviors, we concluded that per is somehow actively involved both in producing circadian rhythm in flies and in setting the rhythm's pace.

It could be a more complicated version of the familiar case of sickle cell anemia: having two mutant copies of a certain gene causes the disease, whereas having only one mutant copy provides protection against malaria.

As for S. praecaptivus, although Dale's lab has conducted exhaustive genetic work to identify the virulence genes causing weevil killing, he says it's not exhaustive enough.

One variation of the IRS1 gene caused lower fat in men.

Harvard Medical School researcher Melina Claussnitzer and her team found that a single variation in the FTO gene caused fat cells that would normally become healthier beige to turn into white fat cells instead.

In test tubes, this gene caused the cells to produce extra amounts of a chaperone molecule that ordinarily helps a cell recognize misfolded proteins.

Carrying just one mutant copy of the gene causes an inherited heart problem called hypertrophic cardiomyopathy (SN: 9/17/16, p. 8).

The team found that a mutation in a single pair of nucleotides in the gene causes seed coat permeability — that is, a change in one pair out of the approximately 1 billion base pairs that make up the soybean genome.

Previous studies have looked mainly at genes causing atherosclerosis and genes affecting the function of platelets and clotting processes as risk factors for ischemic stroke (clot obstructing blood flow to the brain).

Julian Isla, Executive Director of DSF - EU, stated: «One of the most important things for patients with genetic disorders and their families is to be able to give a name to the gene causing their disease.

The researchers believe that mutations in the gene cause the majority of cases of hereditary colon cancer.

In sickle cell disease, a mutation in the beta - globin gene causes hemoglobin to polymerize under low - oxygen conditions in body tissues, deforming red blood cells.

Mutations that inactivate this gene cause severe birth defects in humans.

«This is the first study to illustrate that a structural abnormality in the 3» untranslated region of the PD - L1 gene causes an abnormally high production of PD - L1 protein, consequently aiding cancer immune escape,» says one of the lead authors, Keisuke Kataoka, at Kyoto University.

The teams» three papers, each on Nordic dogs (Swedish Vallhund and Norwegian Elkhound) and each addressing blinding ocular diseases affecting both dogs and people, identified genes causing retinal disease and glaucoma, which may lead to gene therapies for dogs and humans.

A fault in the CHM gene causes choroideremia, in which cells in the retina stop working and slowly die, leading to blindness.

«We don't know exactly how the mutant Huntingtin gene causes the disease, so the idea is that targeting the gene expression cuts off the problem at its source — preventing it from ever having the potential to act,» said Dr Isalan.

A single spelling error in this gene causes the loss of the inner ear's hair cells over time.

We hope that further research may identify why a faulty INPP5K gene causes these symptoms — and that information will help with the search for therapies in the future.»

Researchers used the CRISPR / Cas9 gene editing technique to introduce a segment of a human gene causing Huntington's, with a very long glutamine repeat region, into pig fibroblast cells.

No single malfunctioning gene causes cancer.

«Just as deletion of the Sox2 gene causes the very early embryo to die, it is likely that an abnormality in the regulatory region would also cause early embryonic death before any of the organs have even formed,» said Mitchell.

In another paper in the same issue, a team led by molecular biologist Ronald Plasterk, now at the Hubrecht Laboratory in Utrecht, the Netherlands, reports an intriguing twist: The same genes appear to be responsible for both RNAi and another gene - silencing mechanism known as cosuppression, in which adding extra copies of a gene cause both the new and the existing copies of that gene to be shut down.