Sentences with phrase «genes during regeneration»
The researchers thus went on to study the expression of Wnt genes during regeneration, and found that different members of the gene family were active at different locations across the planarian's head - to - tail axis.
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The researchers used the worm's genomic information to study how gene expression changed during regeneration.
We found that several genes that were previously implicated in cell division were also upregulated during various stages of regeneration.»
In the case of planarians, the gene egr - 4 seems to perform an early control of cell proliferation as a response to amputation, and be involved later in the early differentiation of brain during regeneration.
«We have already observed that gene egr - 4 is regulated by the epidermal growth factor receptor (EGFR) signaling pathway, so it will enable to identify also the factors that activate this pathway during anterior regeneration.
The researchers used a technique called RNA interference (RNAi) to screen a group of genes known to be involved in animal development, in order to study the signaling mechanisms that regulate whether the animal would produce a head or tail during regeneration.
The finding suggests that these varied Wnt genes regulate Smed - beta - catenin - 1 activity to provide the positional information by which the organism specifies the location of its head and tail during regeneration.
Now researchers at the Salk Institute for Biological Studies have identified an essential cellular pathway in zebrafish that paves the way for limb regeneration by unlocking gene expression patterns last seen during embryonic development.
Since regeneration recapitulates in broad strokes embryonic development, during which a complex multi-cellular organism develops from a handful of embryonic stem cells, the researchers began by comparing gene expression patterns between the two processes.
In the more immediate future, the team plans to use global approaches to identify all the targets of Kdm6b.1 during regeneration, and to find out what gives the signal to turn these genes off when regeneration is complete.