Sentences with phrase «genes encoding»

Epilepsy is a common neurological disorder, and mutations in genes encoding ion channels or neurotransmitter receptors are frequent causes of monogenic forms of epilepsy.

ApoC - III ASO treatment lowered plasma TGs in mice lacking lipoprotein lipase (LPL), hepatic heparan sulfate proteoglycan (HSPG) receptors, LDLR, or LRP1 and in animals with combined deletion of the genes encoding HSPG receptors and LDLRs or LRP1.

Using CRISPR / Cas9 technology, we generated biallelic knockout mutations in host genes encoding IRF5 and IL - 10RA in iPSCs, and confirmed their roles in limiting chlamydial infection in macrophages.

We also found high levels of strA and strB, two resistance genes encoding for the aminoglycoside phosphotransferases APH (3 ″)- Ib and APH (6)- Id which inactivates streptomycin by phosphorylation [26].

Collaboration between Genentech Inc. and Lexicon Pharmaceuticals Inc. created a mouse knockout library targeting genes encoding secreted and trans - membrane proteins.

They report that the genes encoding the different subunits of PDE6 in cones and rods arose from ancestral genes that duplicated in the early vertebrate genome doublings, and further expanded in teleosts due to the extra genome duplication that took place in this lineage.

Almost 750 genes encoding a GPCR are identified in the human genome.

Genes encoding 6 sarcomere proteins were studied.

We show that most genes encoding olfactory and vomeronasal receptors have complex, multi-exonic structures that generate different isoforms.

In contrast, transcription of constitutive genes encoding essential subunits of complexes is not coordinated because of stochastic fluctuations.

Upstream ORFs and ATF4 - binding sites are found in many genes, but for the purposes of this review genes that carry out biosynthesis of non-essential amino acids (ASNS, alanine aminotransferase 2, PSAT, serine hydroxymethyltransferase 2, pyrroline -5-carboxylate reductase and glutamate - oxaloacetate transaminase) and genes encoding amino acid transporters (cat1, ASCT1, ASCT2, SNAT2, SNAT7, LAT1, EAAT5 and xCT) are notably abundant [83,120].

In our second study we found that heterozygous mutations in genes encoding β - myosin heavy chain (MYH7), α - cardiac actin (ACTC1), cardiac troponin T (TNNT2), cardiac myosin - binding protein C (MYBPC3), and alpha - tropomyosin (TPM1) account for 30 % of cases of isolated LVNC in adult patients (Probst et al., 2011).

We focused on the 26 genes encoding proteins with no blastp hit in D. melanogaster.

B) Short genes, which includes only genes encoding proteins between 134 and 456 amino acids, inclusive.

Finally, genes encoding antimicrobial peptides (and indeed many non-signaling components of the immune system) are often members of multi-gene families present across insects [5].

Anna Vorobyeva is characterizing human autism - associated single nucleotide variants (SNVs) in genes encoding proteins that regulate global protein synthesis.

For example, during T - cell development genes encoding the TRB molecules are assembled from multiple polymorphic gene segments that undergo rearrangements and selection, generating Vb — Db — Jb combinations that are unique in both length and sequence.

Presenilins 1 and 2 (PS1 and PS2) are the catalytic subunits of the γ - secretase complex, and genes encoding mutant PS1 and PS2 variants cause familial forms of Alzheimer's disease.

Scheller impressed Kandel with his desire to enter the realm of neuroscience with no previous background in the field, and his use of the new recombinant DNA techniques to identify genes encoding for signalling molecules called neuropeptides.

Deletion of genes encoding PU.1 and Spi - B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia

In Nasonia, 38.5 % of genes encoding AMPs are in multi-gene families, compared to 17.1 % of non-immune genes (Fisher's Exact Test P = 0.0081).

But the real molecular advance came in the late 1980s when, first Scheller while at Stanford University, then Südhof, at the University of Texas Southwestern at Dallas, started to clone and sequence the genes encoding these proteins and to investigate their role in vesicle fusion with the pre-synaptic membrane and neurotransmitter release.

To understand the properties of highly induced genes encoding short proteins, we used several tools designed to characterize different protein properties.

While none of the genes encoding signaling proteins have evidence for differential expression after infection, this functional class is notable for the consistency with which we can detect expression in both uninfected and infected samples.

In the absence of functional annotation, genes encoding immune system proteins can thus be difficult to identify, as homology - based approaches generally can not detect lineage - specific genes.

stem cell therapy for ischemic cardiovascular disease; Molecular mechanisms of oxygen homeostasis; Genetic syndromes due to mutations in genes encoding transcription factors

CLU is a confirmed AD gene from genome - wide association study, and encodes apolipoprotein J, which has been shown to chaperone re-entry of Aβ into the brain following export of the peptide from the brain into the blood.49 Interestingly, genes encoding two peptidases known to degrade Aβ were also decreased in expression in blood pre — post intervention as part of the vacation effect: MME (P = 0.00019) and ECE1 (P = 0.0037).

It has been suggested that a high serum cholesterol level is a risk factor for (AD), and that some polymorphisms of genes encoding proteins regulating cholesterol metabolism are associated with AD development.

The sequence uncovers previously uncharacterized genes encoding type IV pili, a surface polysaccharide and iron - acquisition systems.

In P. vivax, genes encoding the exported protein family «PHIST», and exported proteins in general (as predicted by ExportPred47), have paralogously expanded compared to P. cynomolgi (84 vs 54).

The Jans pinpointed the genes encoding Shaker, the fruit fly counterpart of the human voltage-gated potassium channel Kv1.1.

Activation of the UPR induces the production of a family of basic leucine zipper - containing transcription factors that activate transcription of genes encoding functions to reduce the protein - folding load and increase the protein folding capacity of the ER.

He isolated the genes encoding proteins that confer immunological identity to the two main types of cells in the human immune arsenal: the CD4 protein, which dots the surface of helper T cells, and the CD8 protein, which adorns killer T cells.

I am interested in understanding how genetic polymorphisms in genes encoding PTPs can mediate disease pathogenesis, and in defining new drug targets for immune - mediated diseases among the PTPome.

Genes encoding proteins of unknown function constitute 28 % of the essential protein - coding genes set.

The ABCA subfamily is divided into to two subgroups, the first comprises of a) ABCA5 - 6 and b) ABCA8 - 10), the genes encoding these transporters can be found on chromosome 17q24.

In rice, Oryza sativa HOMEOBOX1, a key regulator of meristem maintenance similar to kn1 from maize, controls local BR accumulation by directly targeting and upregulating genes encoding BR catabolism and conjugation enzymes (Tsuda et al., 2014).

At Emory, the labs of Stephen Traynelis and Hongjie Yuan have published an analysis of ExAC data, focusing on the genes encoding two NMDA receptor subunits, GRIN2A and GRIN2B.

Genes encoding rev and tat were derived from SIVmac 32H (pJ5).

Myelin - forming glia coordinately express a unique set of genes encoding myelin structural proteins, and enzymes that synthesize myelin lipids - this coordination is in large part transcriptionally - mediated.

Upregulated genes clustered into at least 7 functional groups, including immediate early genes or transcription factors, cell - cycle related genes, stress - responsive protein genes, cell signaling protein genes, cell adhesion and cell surface protein genes, genes involved in translation and protein turnover, and genes encoding metabolic proteins.

This finding is consistent with the recent discovery with several «eukaryotic» signature genes in these archaeal lineages, including genes encoding proteins such as actin, tubulin, and several proteins involved in transcription and membrane deformation.

We have replaced the tobacco RbcL gene with transgenic loci containing two or three cyanobacterial genes encoding the S. elongatus Rubisco large subunit (Se LS), small subunit (Se SS) either alone or with the putative chaperone RbcX or a gene encoding the carboxysomal protein M35.

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes.

Sarah Weckhuysen and colleagues report a study based on targeted sequencing of the genes encoding the components of the GATOR1 (DEPDC5, NPRL2, and NPRL3) and GATOR2 (MIOS, SEC13, SEH1L, WDR24, and WDR59) complex in European probands with focal epilepsy with or without focal cortical dysplasia.

Massive lateral transfer of genes encoding plant cell wall - degrading enzymes to the mycoparasitic fungus Trichoderma from its plant - associated hosts

The authors report that genes encoding heme synthetic enzymes (that generate porphyrin intermediates) are expressed in pigment cells, and the first three enzymes in the heme synthetic pathway are also required for proper pigmentation.

We found that genes encoding subunits of the Mg - chelatase complex and 3,8 - divinyl protochlorophyllide a 8 - vinyl reductase (DVR) likely function directly downstream of the GATAs and that DVR expression is limiting in the pale - green gnc gnl mutants.

In our current study, genes encoding several of these influx transporters, such as OCT3, OCTN1, OAT2, and OATP3 were up - regulated.

Our genomes contain separate genes encoding each one.