This finding is consistent with the recent discovery with several «eukaryotic» signature genes in these archaeal lineages, including
genes encoding proteins such as actin, tubulin, and several proteins involved in transcription and membrane deformation.
Not exact matches
The artist of this depiction, Raquel Lieberman, is the principal investigator of the team that confirmed a Y - shaped structure, the first ever found that was
encoded as
such by a
gene and not constructed out of
protein component parts.
That
gene, McIntire's team discovered,
encodes a
protein that transports acetylcholine from nerves to muscles, the first
such transporter discovered.
«This
gene encodes a
protein which recognises the presence of a certain number of cold - inducing microbes in a cell,
such as the respiratory syncytial virus (RSV) or rhinoviruses,» explains Samira Asgari of EPFL, who designed the experiments.
Some newer vaccine candidates use harmless viruses
such as modified adenoviruses to deliver
genes that
encode immunizing viral
proteins.
«We have developed a bioinformatics approach that suggests that
such changes might alternatively occur through changes in the interactions of
proteins encoded by the
gene.»
For example, they identified SNVs in
genes encoding the collagen
proteins that make up bone and cartilage, and in
genes where other mutations have caused defects similar to Ata's,
such as fewer - than - normal ribs or short stature.
Such is the case for a DNA letter in the
gene that
encodes the
protein called tumour necrosis factor receptor 1 (TNFR1).
They found amplification of several
such genes, specifically CD274 (which
encodes the PD - L1 immune checkpoint
protein) and PDCD1LG2 (which
encodes the PD - L2 immune checkpoint
protein).
Instead, researchers will have to rely on other evidence that the mutations are harmful,
such as lab studies of the
proteins encoded by the
genes.
But after several questions about potential outcomes of
such early research, Niakan did «wildly speculate» that, if certain
genes are found to be particularly important for development, one eventual approach might be to check during IVF whether eggs were making the
proteins encoded by those
genes, and if not, then add them to culture media.
Others were found in
genes encoding regulatory
proteins that are linked to psychiatric illnesses
such as schizophrenia and the developmental disorder Smith — Magenis syndrome.
Functional perilipins (PLIN
proteins encoded by the PLIN
genes)(Lu et al., 2001) have been identified in very diverse organisms
such as Drosophila (Teixeira et al., 2003), Dictyostelium (Du et al., 2013) and fungi (Wang & St Leger, 2007) and
protein databases list clear orthologues in diverse, non-plant eukaryota, including the simplest metazoan Trichoplax adherens, sponges, crustaceans, and choanoflagelates (UniProt
proteins B3RRM2, I1GA14, G5DCP6, F2UJD9, respectively).
Herein, we identify 382 of the 482 M. genitalium
protein - coding
genes as essential, plus five sets of disrupted
genes that
encode proteins with potentially redundant essential functions,
such as phosphate transport.
A rare, premature aging disease, Hutchinson - Gilford progeria is caused by a single point mutation in the
gene encoding lamin A, which forms a
protein scaffold on the inner edge of the nucleus that helps maintain chromatin structure and organize nuclear processes
such as RNA and DNA synthesis.
Epigenetics provides another way of understanding how
genes and environment interact in that there is increasing evidence that
gene expression is moderated by the environment in which the organism grows and develops.15 Genetic information is
encoded not just in DNA linear sequences but in epigenetic changes in chromatin structure
such as DNA methylation or covalent modifications of the DNA - binding
proteins.