The answer is that it forms the platform for illuminating the interaction between the use of animal manure and the appearance of
genes for antibiotic resistance in soil.
Examining E. coli bacteria, which are responsible for about 80 % of urinary tract infections, the researchers found an identical
gene for antibiotic resistance in both humans and animals.
Not exact matches
Over the past 60 years,
genes for antibiotic resistance have gone from rare to commonplace
in the microbes that routinely infect our bodies.
«You've got the
genes encoding
for resistance in the soil beneath these operations,» he says, «and we know that the majority of the
antibiotics animals consume get excreted intact.»
One reservoir
for resistance genes where they can be exchanged among bacteria — and possibly end up
in the food chain — is the sediment
in marine fish farms even when no
antibiotics have been applied.
From isolated caves to ancient permafrost,
antibiotic - resistant bacteria and
genes for resistance have been showing up
in unexpected places.
Rudich and his team then explored the
genes in these bacteria, checking
for antibiotic resistance — a trait that can arise owing to elevated use of
antibiotics but also naturally, especially
in soil bacteria.
Collected
in Denmark — where
antibiotics were banned
in agriculture from the 1990s
for non-therapeutic use — the soil archives provide an «
antibiotic resistance timeline» that reflects resistant
genes found
in the environment and the evolution of the same types of
antibiotic resistance in medicine.
However, as Wilson explains: «The
genes necessary
for resistance are often activated only when required (i.e., when the
antibiotic is present
in the environment), and so - called leader or signal peptides play an important role
in this process.»
While
antibiotic resistance genes are not harmful
in themselves, they limit the use of
antibiotics for treating bacterial infections and pose a serious threat to global public health if they get transmitted to humans from environmental sources, such as compost.
The scientists have also detected
resistance genes for sulphonamides and another
antibiotic in the treated wastewater — which will be turned into snow at a nearby ski resort,
in a relatively pristine part of a river basin, later this year.
That background makes it important to characterize «both the natural occurrence of the
antibiotic -
resistance genes and the anthropogenic load, and where those
genes come from, and it's good to do it
in a quantitative way,» as Pruden's team did
for the South Platte, says Joakim Larsson of the University of Gothenburg, Sweden, who has tracked
antibiotics and
resistance genes in India and Sweden.
Though well - known pathogens weren't seen
in abundance, the presence of
genes for antibiotic resistance,
resistance to water disinfectants and virulence raises concerns because bacteria can share such
genes to potentially become more significant health threats.
«If mcr - 1 is present
in India then that will be a disaster,» says Ghafur, who fears it will spread as fast as did
genes for resistance to another
antibiotic of last resort, carbapenem.
Conjugation is the main route
for horizontal
gene transfer
in bacteria and is responsible
for the spread of
antibiotic resistance.
An assessment of the risks associated with the use of
antibiotic resistance genes in genetically modified plants: report of the Working Party of the British Society
for Antimicrobial Chemotherapy.
The team, reporting its work
in Nature Nanotechnology doi: 10.1038 / s41565 -017-0029-3, says that it is now busy further developing tools
for metagenomics - based risk assessment —
in particular with respect to
antibiotic -
resistance genes and their relation to environmental stressors.
To characterize the resistome
in detail we searched the metagenomes
for signatures of known
antibiotic resistance genes.
Significant differences
in abundances were found
for several
resistance genes associated with
resistance to several classes of
antibiotics, including sulfonamides, fluoroquinolones and aminoglycosides (Figure 2 and Tables S12, S13, S14, S15, S16).
In this manner, copies of
genes that code
for antibiotic resistance can be passed around, and the recipients can reproduce themselves at a furious rate, further propagating the
gene.