There's no clearly identified gene or
genes for mental illnesses, no blood test, no outward physical signs and no simple technical fix.
Not exact matches
In addition to the new work's potential
for RS, there is speculation that it could pave the way to treatments
for other neurological disorders, such as learning disabilities, schizophrenia, autism and newborn encephalopathy as well as some
mental retardation that has also been linked to the Mecp2
gene.
These results can also be used by researchers studying the genetic underpinnings of
mental disorders, as they indicate that the same
genes might be associated with increased risk
for various psychiatric disorders.»
The researchers measured heritability — the amount of variation in a characteristic that can be attributed to
genes —
for a wide variety of human traits including blood pressure, the structure of the eyeball and
mental or behavioral disorders.
Today theories of links between genetics and behavior have led to what Rafter calls ««new» or «liberal» eugenics» that involves the elimination of «bad»
genes by choice, such as the abortion of fetuses that test positive
for mental retardation.
The case
for familial and genetic vulnerabilities in female twins,» was published in the Annals of Behavioral Medicine in January 2014 and showed that the associations between caregiving and different types of psychological distress (depression, anxiety, perceived stress and perceived
mental health) depend largely on a person's
genes and upbringing — and less so on the difficulty of caregiving.
This work is part of the ongoing Duke Neurogenetics Study (DNS), a comprehensive study linking
genes, brain activity and other biological markers to risk
for mental illness in young adults.
Booth says these findings may suggest a link between the
genes responsible
for exercise motivation and the
genes responsible
for mental development.
In the last four years scientists have cloned and sequenced many
genes carrying defects that cause disease, including those responsible
for Fragile X linked
mental retardation, different forms of muscular dystrophy, and most recently Huntington's disease.
The study points to a future of active
gene discovery
for mental disorders» said Thomas Lehner, Ph.D., chief of the NIMH Genomics Research Branch, which funds the project.
Additionally, in demonstrating the usefulness of the new method, the discovery paves the way
for faster progress toward identifying
genes involved in complex
mental illnesses such as autism and schizophrenia — as well as potential drugs
for such conditions.
«Our findings showed that an in increase in methylation of the SKA2
gene is associated with decreased cortical thickness in the prefrontal cortex, which may play a role in the development of PTSD and may explain why this
gene predicts risk
for mental health problems, like PTSD and suicide,» explained lead and corresponding author Naomi Samimi Sadeh, PhD, assistant professor of psychiatry at BUSM and a psychologist in the National Center
for PTSD at VA Boston.
For the first time, researchers report identifying a biological marker: the over-production of specific
genes that could be a diagnostic indicator of
mental illness in female psychiatric patients.
Figuring out what these jumping
genes truly do in the human brain is the «next frontier»
for understanding complex
mental disorders, he says.
Researchers found that the
gene XIST, which is responsible
for inactivating one of the two copies of the X chromosome in cells that store genetic material, works overtime in female patients with
mental illnesses, such as bipolar disorder, major depression and schizophrenia.
People with Fragile X syndrome — the most common inherited type of
mental retardation — lack a protein called FMR1 because the
gene for FMR1 is laden with extra DNA.
The prevailing theory
for decades has been that extra copies of
genes on a specific area of chromosome 21, known as the Down syndrome critical region (DSCR), cause the
mental and physical features of Down syndrome.
For instance, says Korenberg, the data could help scientists to link
genes that seem important in certain
mental disorders, such as schizophrenia or autism, to specific brain - wiring abnormalities.
Scientists have
for the first time shown how the disruption of a key
gene involved in
mental illness impacts on the brain.
Variations in the
genes we inherit from our parents ensure that each brain is uniquely wired, leading to differences in how we think, learn and behave, and in our propensity
for mental illness.
Find out her best advice
for optimizing
gene function through sleep, positive
mental attitude, gratitude, time outside in nature, managing the stress response and more.
Any
mental disorder is probably encoded
for by multiple
genes, meaning it can not be detected by a simple genetic test as is possible
for conditions like Down's syndrome or cystic fibrosis.
This is a genetic weakness, believed to be caused by the relatively small
gene pool that was necessary to breed
for specific characteristics (both physical and
mental).
Over the past 20 years, American psychiatry has gone from the Freudian model of blaming the parents
for all the problems to a biological model of
mental illness, which blames the
genes.
Moreover, a very important, but difficult to test, alternative explanation
for many of the ACE Study findings is that inherited
genes for health problems or some temperamental qualities create a spurious connection between abuse and neglect by parents or other family context variables and
mental and physical health conditions in their offspring.
Corticosteroid receptor -
gene variants: Modulators of the stress - response and implications
for mental health