In contrast, among Old World (African) primates such as humans, the two different X chromosome genes duplicated so that each X chromosome now carries
the genes for both receptor types, giving both males and females trichromatic color vision.
The organism has a huge suite of
genes for receptor and signaling proteins, far more than in most similar organisms.
Genes for a receptor that helps transmit nerve signals in animals have been found in, of all things, plants.
That means that the approach that worked so well for finding the sweet receptor — identifying a likely
gene for the receptor, destroying it in mouse embryos, and proving that the resulting mice are unable to taste sweetness — will not work in the search for the salt receptor.
Aedes has already been shown to possess extra
genes for receptors that detect odors, for proteins that help it purge pesticides from its system, and for controlling the makeup of its outer shell.
A variant in
the gene for this receptor previously had been linked to asthma in genetic studies, but the potential role of the receptor, called CDHR3, in asthma was unknown.
They cultured the cells in the lab for a day, then exposed them for 3 days to a virus which contained the normal
gene for the receptor.
They went on to find new
genes for receptors sensitive to different wavelengths of light.
The mouse T cells developed receptors for this clearly suspicious invader and
the genes for the receptors is what He later put on human T cells.
Not exact matches
Caplan said the best bet
for super powers through
gene editing would be greater muscle strength, better memory, quicker reaction times, better night vision, and turning up
receptors to experience things like alcohol, drugs, and sex more intensely.
Patients that have a defective
gene called RPE65 — which is responsible
for producing a protein that makes light
receptors in the eye — suffer from leber congenital amaurosis and retinitis pigmentosa, yet now have hope.
Just before Election Day — surely not a coincidence — scientists report an association between liberal political views and DRD4, a
gene that produces a
receptor for the neurotransmitter dopamine.He....
UT Southwestern biochemists studying mouse models found that the two proteins − steroid
receptor coactivators 1 and 2 (SRC - 1 and SRC - 2)-- control
genes for pulmonary surfactant components that promote the initiation of labor.
When similar analysis was performed on the db mice, it was found that the disrupted db
gene was responsible
for encoding a protein that functions as a leptin
receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.
We identified some specific resistance
genes that code
for receptor - like proteis (RLPs) and described how they operated against the pathogens.
The authors note that DRD4 in particular, a dopamine
receptor gene, has been extensively studied
for its involvement in novelty - seeking behavior in primates, fish and birds.
What's more, the
gene codes
for a chemical
receptor involved in many brain functions, such as learning and memory, so the
gene might also be involved in behavioral disorders.
To see if any other
receptors existed, Rodriguez's team took tissue from the vomeronasal organ — a pheromone - detecting sense organ found in the nasal cavity of mice, and some other mammals — and searched
for genes expressing other possible smell
receptors.
Using
gene mapping techniques, the researchers zeroed in on a mutation in the
gene for hypocretin
receptor 2.
«We found that interbreeding with archaic humans — the Neanderthals and Denisovans — has influenced the genetic diversity in present - day genomes at three innate immunity
genes belonging to the human Toll - like -
receptor family,» says Janet Kelso of the Max Planck Institute
for Evolutionary Anthropology in Leipzig, Germany.
Steve: So you might have a
gene for a particular brain
receptor or, I think what you talk about in the article is not actually the structure of the
receptor molecule, but the amount of
receptors that you actually produce?
Since
genes for the T - cell
receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig - like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B - cell multigene families
for the Ig heavy chain, and the Ig kappa and lambda light chains.
«Fibroblast growth factor
receptor inhibitors are new therapies being developed in clinical trials
for patients whose cancer cells have genetic alterations in this family of
genes,» says Roychowdhury, a member of the OSUCCC — James Translational Therapeutics Program.
In 2004 the Nobel Prize in Physiology or Medicine went to Linda B. Buck and Richard Axel
for their research showing that there is a huge family of
genes that encode proteins called olfactory
receptors.
Recently he found that eight of the youngsters have a defect in a
gene that codes
for a
receptor protein called melanocortin - 4, known to regulate eating in mice.
The «business end» of the
gene — which codes
for the actual
receptor — was fairly constant in humans, suggesting that individual differences exist within the
gene's regulatory areas.
The American cockroach has
genes that code
for more than 150 scent
receptors and 500 taste
receptors, the most found in any insect so far.
One key
gene encodes the making of a
receptor called TREM2, a docking site
for molecules on the surface of microglia and other innate immune cells.
Destroy a
gene for a common sodium
receptor and your mice won't survive long enough to be born.
Those animals with more active forms of the
gene had higher numbers of mu
receptors in their tissues — and higher tolerances
for pain.
In the pups of inattentive mothers, they found that
genes regulating the production of glucocorticoid
receptors, which regulate sensitivity to stress hormones, were highly methylated; in the pups of conscientious moms, the
genes for the glucocorticoid
receptors were rarely methylated.
The answer may lie in the
gene that codes
for the umami taste
receptor.
Perhaps most significantly, in a study led by Frances Champagne — then a graduate student in Meaney's lab, now an associate professor with her own lab at Columbia University in New York — they found that inattentive mothering in rodents causes methylation of the
genes for estrogen
receptors in the brain.
Research on prairie voles suggests that it's possible to predict which voles will exhibit pair - bonding behavior just by looking
for those expressing the
gene for AVPR1a, a specific vasopressin
receptor.
The normal
gene codes
for a
receptor for ethylene, a gaseous plant hormone that ripens fruit.
The team spliced a nonfunctional
gene for the ethylene
receptor, taken from a common laboratory plant called Arabidopsis, into petunias.
The second
gene, TNFRSF6B, encodes a
receptor related to those that bind tumor necrosis factor (TNF)-- a key chemical signal
for triggering inflammation in IBD as well as in patients with other autoimmune disorders such as rheumatoid arthritis and psoriasis.
They sequenced the
gene coding
for the
receptor in patients with either severe skin allergies or hyper - IgE syndrome, a rare condition in which the body produces too much IgE.
Juha Tapanainen of Oulu University Hospital in Oulu and colleagues at the University of Helsinki studied 15 brothers of infertile women who had mutations in the
gene coding
for the FSH
receptor.
The mutation, in a
gene called HTR2B, prevents production of the serotonin 2B
receptor, a key docking point in brain cells
for the neurotransmitter serotonin.
The researchers mated female mice unable to make the
receptor for type I interferons to males with one copy of the
gene needed to make the
receptor.
Although the men with the mutant
genes produced FSH, support cells
for the sperm - producing cells in their testes lacked the
receptors for the hormone.
Lindstrom and his colleagues inserted
genes for human nicotinic
receptors into frog eggs and incubated them with levels of nicotine similar to those found in the blood of a human smoker.
The most common, found in nearly two - thirds of the samples, were abnormalities in
genes responsible
for the androgen
receptor — a cell structure that sends growth signals in response to the male hormone androgen.
Zwiebel and colleagues scanned the mosquito genome looking
for genes similar to those that generate fruit fly odorant
receptors, proteins that project from nerve cells and initiate a biochemical cascade when they encounter certain molecules in the air.
They found
genes for five new
receptors, all of which belong to a known family of proteins called formyl peptide
receptors (FPRs).
Sleep - wake cycles and our understanding of narcolepsy have been advanced by the discovery of orphan
receptors, as well as their associated ligand peptide hormones and the
genes that code
for them.
Many
genes are likely to influence delay discounting; and some of Dr. Ahokhin's preliminary data suggest that these «impulsivity
genes» may include
genes coding
for enzymes that synthesize the neurotransmitter serotonin and
receptors where serotonin binds in the brain.
The researchers scoured the already deciphered mouse genome, looking
for genes that might encode additional
receptor proteins in its olfactory system, the sensory cells that connect the nose to the brain.
The former target, say, using
gene editing techniques to inactivate HIV
receptors and achieve resistance of blood cells to the virus (which Sangamo BioSciences is working on in clincial trials) is different than helping parents who both carry
genes for Huntington's Disease to have a child that is free of the disease (a change to the genome that would be passed on to future generations and would likely not be very commonly needed).