Sentences with phrase «genes function without»

Our life experiences exert a profound influence on how we age and can even alter the ways genes function without changing the underlying DNA sequence; these genetic changes are called epigenetic traits.

Her postdoctoral work in the laboratory of David Sweatt, the chair of the Neurobiology department at the University of Alabama at Birmingham, focused on the emerging science of epigenetics, the study of changes in gene function without a change in DNA, something that has only recently come to the fore of neuroscience.

Not exact matches

What all these have in common is that, without any central control, individual units (genes, cells neurons or workers) respond to simple, local information, in ways that allow the whole system (cells, brains, organisms or colonies) to function: the appropriate number of units performs each activity at the appropriate time.

Three children in this family were born without fully functioning ATF6 genes.

Consider what that means: Without a mutation to the DNA code itself, the attached methyl groups cause long - term, heritable change in gene function.

The difficulties are well illustrated by last month's rejection of a patent application in the US, by the Institutes of Health, for DNA sequences without knowledge of the function of the gene.

(Because of the strong sequence similarities between the two genes, the scientists have not yet been able to turn off one without the other, so differences between their functions are still unclear.)

Yet they would be nearly impossible to create without genetic engineering used to evaluate gene function, said Nora Lapitan, a wheat geneticist at Colorado State University.

Through the combination of linkage data and exome sequencing, they have identified a deletion or loss of a single base in the gene encoding STAG3, which results in a prematurely truncated protein without function.

They took short pieces of RNA which are able to turn off the function of specific genes, attached them to highly concentrated viruses, and then, using ultrasound to guide the needle without damaging surrounding tissue, they injected the viruses into the sacs of mouse embryos.

They also want to be able to insert more subtle mutations, such as those reported in HIV - resistant individuals, which could alter cell function just enough to confer resistance but without fully deactivating the gene and impeding cell function.

Without these tools, scientists are less able to link specific genes to cell behavior or determine how microbes interact within their environment and with one another — critical information for understanding how ocean ecosystems function.

Researchers found that all 15 children with SMA1 treated with the gene therapy were functioning without any major disability or progression of their disease.

Once an organism can draw on two full sets of essentially the same genes, it can begin «to de-evolve certain of the genes in one set and adapt them to some other function — importantly, without compromising the gene's original function,» she says.

We included genes with and without a known function in olfactory and vomeronasal signaling that cover the whole range of expression values observed (Table S1).