Designed to improve the utility and availability of increasingly diverse CRISPR - Cas genome editing systems, the new CRISPRdisco automated pipeline helps researchers identify CRISPR repeats and cas
genes in genome assemblies.
The new CRISPRdisco automated pipeline helps researchers identify CRISPR repeats and cas
genes in genome assemblies.
Not exact matches
Other labs will pitch
in for the final
assembly and annotation of the
genome, as well as analyzing the functions of the new
genes discovered.
Assembly of the Norway spruce
genome has shown that LTR retrotransposons
in particular are frequently nested within the long introns of some
gene families (Nystedt et al. 2013).
Following the sequencing and
assembly of a Joshua tree reference
genome, we are working to understand what
genes underlie Joshua tree's adaptation to the extreme climates
in which it grows, from the margins of Death Valley to the high desert.
High - density oligonucelotide arrays were designed to target the computationally predicted 3 ′ UTRs of OR and VR
genes and probe the expression of all receptors annotated
in an early
genome assembly [9], [31].
Recently, our team released an annotated
genome assembly of C. krusei via NCBI Genbank, and we are currently working with the CDC to assemble
genomes and predict
genes for C. auris isolates from the other major clades and other closely related species; we plan to share these data
in the coming weeks.
In the most recent
assembly of the reference mouse
genome (GRCm38) over 1,200
genes are annotated as coding for ORs and around 530 for VRs with a smaller number of TAAR and FPR
genes.
These studies demonstrate that the two important protein complexes, condensin and cohesin, are both essential for the
assembly of the functional
genome architecture, but their roles
in the 3D
genome organization (
gene contacts and topological domain organization) are significantly different.