Sentences with phrase «genes in mouse loss»

mm10 loss developmental genes are genes in mouse loss hotspots that are annotated with developmental process GO terms.

Not exact matches

The loss of a single gene in mice can affect social behavior and impair their brains» ability to filter out distractions — both characteristics of several neurological diseases in humans.

The French team and a British group that discovered the mouse gene both decided to see if the mutation — which hampers the production of a protein called myosin VIIA — might, as in the mice, explain inherited deafness without other sensory loss.

«Gene therapy restores hearing in deaf mice: Proof - of - principle study takes a step toward precision medicine for genetic hearing loss.»

In a mouse model of eczema, loss of the HTR7 gene in mice led to significantly less scratching and less severe skin lesionIn a mouse model of eczema, loss of the HTR7 gene in mice led to significantly less scratching and less severe skin lesionin mice led to significantly less scratching and less severe skin lesions.

Researchers from the Eaton - Peabody Laboratories of the Massachusetts Eye and Ear and Harvard Medical School have created a new mouse model in which by expressing a gene in the inner ear hair cells — the sensory cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafness.

Christiano's lab uses specially bred mice to pinpoint genes involved in hair loss.

«To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age - related and noise - induced hearing loss,» Dr. Chen said.

After his team first observed hair loss in Treg - deficient mice, Rosenblum learned that the genes associated with alopecia in previous studies are almost all related to Tregs, and treatments that boost Treg function have been shown to be an effective treatment for the disease.

Now that they have a FAN1 knockout mouse in hand, and they have confirmed that it mimics many aspects of karyomegalic interstitial nephritis in humans, Smogorzewska's lab can start to delve into how the loss of the gene causes kidney degeneration.

In addition, loss of the Esrp1 gene in mice leads to changes in the shape of the inner ear that is very similar to the situation with the siblingIn addition, loss of the Esrp1 gene in mice leads to changes in the shape of the inner ear that is very similar to the situation with the siblingin mice leads to changes in the shape of the inner ear that is very similar to the situation with the siblingin the shape of the inner ear that is very similar to the situation with the siblings.

«Loss of memory in Alzheimer's mice models reversed through gene therapy.»

According to Saura, «this study opens up new perspectives on therapeutic prevention and treatment of Alzheimer's disease, given that we have demonstrated that a gene therapy which activates the Crtc1 protein is effective in preventing the loss of memory in lab mice».

Secondly, this is the first research to demonstrate that the loss of hair cells and hearing can be curtailed in USH3 mice by clarin - 1 gene therapy.

Researchers from the Institute of Neuroscience at the Universitat Autònoma de Barcelona have discovered the cellular mechanism involved in memory consolidation and were able to develop a gene therapy which reverses the loss of memory in mice models with initial stages of Alzheimer's disease.

In the animal studies, mice containing the gene expressing human resistin and infected with a parasitic worm similar to the human hookworm experienced excessive inflammation, leading to increased weight loss and other symptoms.

«We found that gene therapy blocked progressive hearing loss and improved hearing in treated mice by nearly four orders of magnitude compared to untreated sibling controls,» said Alagramam.

In previous work, Dr. Ryosei Minoda, head of the Department of Otolaryngology at Kumamoto General Hospital, reported that hearing loss was restored by gene therapy to the inner ear of Connexin 30 deficient fetal mice.

David Liu at Harvard University and his colleagues have tried doing this with CRISPR in mice carrying a mutated copy of the gene TMC1, which causes a rare form of hearing loss in people.

Interestingly, Human DNA gains and losses and mouse DNA losses all occurred near genes involved in fundamental cellular / metabolic processes.

Although DNA gain and loss in human occurred mostly in different regions, they both tended to impact on the same biological processes, while in mouse DNA loss was enriched for developmental genes and DNA gain did not associate with any particular biological process.

However, for some mouse DNA losses the case may be different, as in the mm10 genomic background they mostly occurred near genes involved in developmental processes.

Loss of Vascular Endothelial Growth Factor A (VEGFA) Isoforms in the Testes of Male Mice Causes Subfertility, Reduces Sperm Numbers, and Alters Expression of Genes That Regulate Undifferentiated Spermatogonia.

Mutant mice maintained on a genetic background containing a contribution from C57BL / 6J have the potential to harbor a loss - of - function mutation in the nicotinamide (NAD) nucleotide transhydrogenase gene (Nnt, Chromosome 13).

The Czech Centre for Phenogenomics (CCP), through its membership in INFRAFRONTIER and IMPC, is a partner in a collective global network that aims to comprehensively and systematically analyze the effect of loss of function gene mutations in mice.

The 120 repeat R6 / 2 mouse model of HD expresses a human transgene containing exon 1 of the mutant huntingtin gene and faithfully replicates many of the symptoms of the disease, including progressive loss of body weight, marked impairments in cognition, and severe motor deficits.

Furthermore, sgRNA targeting GPI anchor protein pathway genes induced loss of function mutations in human and mouse cell lines measured by FLAER labelling.