Sentences with phrase «genes in the cell shape»
In the light of a review detailing the role of these genes in the cell shape changes leading to invagination, and of recent findings showing the expression of twist as mechanically sensitive, we suggest that the expression of twist in the mesoderm could alternatively be maintained by mechanical strains developed during mesoderm invagination.
https://science.institut-curie.org/ Not exact matches
Project members also catalogued sequences that mark areas where DNA unwinds from the round histone proteins that maintain the shape of chromosomes, allowing the cell's transcription machinery to activate genes in those areas.
To test that idea in the ragworm, Tomer used a technique he had developed to examine the complex brains of small creatures with unprecedented clarity: He created a high - resolution map of the worm's brain cells according to the genes they express, not just their shape and location.
The process, reported in Human Reproduction, utilizes DNA fingerprinting (an assessment of active genes in a given cell) to boost the success rate of IVF and lower the chances of risky multiple births by identifying which of several five - day - old embryos are most likely to result in pregnancy The new method, which will replace unproved alternatives such as choosing embryos based on their shape, is likely to up the success of women becoming pregnant and lower their chances of having multiple births.
By identifying novel genes and molecular pathways involved in shaping a taste cell's function, these findings may someday allow scientists to treat taste disorders, characterize new taste qualities, or even fine - tune a person's taste perception to encourage healthier eating.
But the cells also changed shape and other properties in the absence of the protein in ways that reduced the likelihood that they would travel away from the tumor — a sign that myoferlin not only changes genes in cancer cells, but also alters the cells» mechanical properties.
The team also found five genes in domestic cats that influence the migration of neural crest cells, stem cells in the developing embryo that affect everything from skull shape to coat color.
The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.
The research team found that this non-coding RNA fragment maintains healthy cells through two mechanisms: Firstly by regulating the levels of DIRAS3, one of its neigboring genes that is involved in cell replication; secondly by suppressing a network of genes that prepare cells to change their shape and prepare for metastasis.
When two copies of the altered hemoglobin gene are present, they cause the shape of the hemoglobin to change so much that the «sickled» blood cells don't flow freely in the blood vessels, causing excruciating pain.
Additional micro-patterning of the substrate changes the cytoskeleton in the cell and the shape of the nucleus, which cause the genes in the cell to change.
The elongated fibroblasts reprogrammed to become more T - cell - like in shape and hundreds of T - cell genes were also expressed in these skin cells.
The gene discovered in the research couples the exocytosis - regulating protein Sec10 with formin, a protein that regulates the remodeling of the actin cytoskeleton critical to forming cell shapes.
They have a disruptive mutation in the gene for the blood cell molecule hemoglobin; as a result, their red blood cells typically take on a sickle shape, which causes them to clog up blood vessels, leading to intense pain, especially in the long limb bones.
Taking a similar tack, Littman's team later uncovered a gene switch called RORgammat, which shapes the development of a subset of helper T cells called Th - 17 cells, which abound in the intestines.
My lab studies genes and signals in cells that regulate the growth and shape of plants.
Helical cell shape was restored by supplying the gene in trans.
Sickle cell disease (SCD) is caused by a genetic abnormalities in the hemoglobin genes which leads to the production of abnormally shaped mature red blood cells, provoking various acute and chronic complications with an accompanying high mortality rate [1].