Sentences with phrase «genes in the mouse tumors»

The researchers therefore decided to take a closer look at the protein - encoding genes in the mouse tumors.

If they succeed, they will then «knock out» either the p14ARF gene or the p53 gene in mouse tumors to see how the drug fares.

Not exact matches

Northwestern Medicine scientists have identified a small RNA molecule called miR - 182 that can suppress cancer - causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor.

Now, in a provocative study that raises unsettling questions about the widespread use of vitamin supplements, Swedish researchers have showed that relatively low doses of antioxidants spur the growth of early lung tumors in cancer - prone mice, perhaps by hindering a well - known tumor suppressor gene.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Mice engineered to express Lin28 in their kidneys developed Wilms tumor, which regressed when Lin28 was withdrawn, indicating that strategies aimed at blocking or deactivating the gene hold therapeutic promise for children with Wilms.

In this mouse model, mutations in Kras and p53 genes resulted in the formation of individual tumor cell populations that were labeled with different colorIn this mouse model, mutations in Kras and p53 genes resulted in the formation of individual tumor cell populations that were labeled with different colorin Kras and p53 genes resulted in the formation of individual tumor cell populations that were labeled with different colorin the formation of individual tumor cell populations that were labeled with different colors.

A virus that has shown promise as a vector for human gene therapy causes liver tumors in neonatal mice.

BCL - 2 is present in high amounts in many tumors and helps cancer cells to survive, but when the BCL - 2 gene is blocked by MM41 in mice, the cancer cells succumb to apoptosis and die.»

By deleting the gene that expresses p300, the researchers safely reduced Treg function and limited tumor growth in mice.

Researchers at The Rockefeller University have shown that a new technique using RNA interference is able to find genes that cause epidermal tumor growth in months rather than the decades it may take using traditional methods employing specially bred, genetically altered mice.

«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.

Yilmaz, who studies colon cancer and how it is influenced by genes, diet, and aging, decided to adapt this approach to generate colon tumors in mice.

Using the gene - editing system known as CRISPR, MIT researchers have shown in mice that they can generate colon tumors that very closely resemble human tumors.

They've used a gun powered by pressurized helium to fire microscopic gold bullets, coated with genes, into skin cells surrounding tumors in mice.

«A new tumor suppressor gene for breast cancer in mice.»

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

In any case, she and Yang have found that a week of gene shots three to five times daily not only shrinks the tumors but lengthens the lives of the mice.

Radiation oncologist Anna Saran at the Italian National Agency for New Technologies, Energy and the Environment in Rome and colleagues studied mice with a mutation in a gene called Patched that makes them susceptible to brain tumors early in life.

The analysis also found that a significant fraction of tumors contained rearrangements and mutations of a gene called PREX2, and experiments confirmed that cancer - associated mutations of PREX2 promoted the growth of human melanoma cells in mice.

Next steps include He's collaboration with Piedmont Atlanta Hospital to retrieve T cells, liver cancer cells and healthy tissue normally removed from patients during surgery, put the mouse receptor genes on these T cells and monitor in a dish both how those cells now fight the tumor and react to healthy human tissue.

In this latter group, they found thirteen gene - environment interactions, also called «genetic loci,» which contribute to the tumor susceptibility when the mouse is exposed to low - dose radiation.

Bradner and Mitsiades had reported in Cell in 2011 that the inhibitor blocks the Myc cancer gene and thereby slows the growth of multiple myeloma tumors in mice.

However, their initial finding demonstrated that progenitor derived from iPSCs generated using lentiviral gene transduction led to the high incidence of highly aggressive tumors in immunodeficient mice after transplantation under the kidney capsule.

After implanting the tumor, they gave the mice a drug to trigger the tumor cells to express the aquaporin reporter gene, which made the tumor look darker in MRI images.

The researchers showed that this technique was successful in monitoring gene expression in a brain tumor in mice.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

Scientists exploit gene therapy to shrink tumors in mice with an aggressive form of breast cancer.

This modification is of special interest to p53 - dependent anti-senescence and pro-longevity functions because genetically engineered mice with p53 serine18 mutated to alanine (p53S18A) show increased ROS levels, metabolic stress, tumor frequency, premature aging symptoms and defects in regulation of a subset of p53 target genes that include sestrins.

Thus, chronically increased p53 activity causes premature aging in mice, whereas transgenic mice with extra copies of p53 and ARF genes under normal regulation show tumor resistance and extended life span.

One mouse was sequenced to 15x coverage, and among the handful of somatic nonsynonymous mutations found, one was recurrent, not only in the APL mice, but also in the same gene in human tumors.

We are also applying CRISPR / Cas9 - mediated genome engineering to develop novel mouse models in order to explore the impact of gene dosage alterations on tumor development in vivo.

These mice developed multiple independent mammary tumors of which the majority resembled human ILC in terms of morphology and gene expression.

These kind of mice are an extraordinary resource for modeling human disease; for instance, research has found that mice that are genetically mutated to carry the BRCA1 gene (a human breast cancer gene) behave more similarly to human cancer patients than those mice who have had a tumor physically transplanted in.