Sentences with phrase «genes in the region of»

However, the team also found virulence genes in regions of the genome that are not so variable.

They add that other genes in the region of the genome around Gp - 9 are probably involved in regulating fire ant social organization as well.

The genes in the regions of the genome that have been modified by PRC2 are switched off, or become silenced.

Not exact matches

I spent a year researching a 96 basepair region of the non-coding region of a gene in an attempt to demonstrate its supposed enhancer properties on that gene.

The reliability and stability of these methods were described by Wu et al. 27 Illumina tag sequencing of the 16S rRNA gene V4 - V5 hypervariable region was performed at the Marine Biological Laboratory in Woods Hole, Massachusetts, using established methods.28, 29 Details of sequencing methods, quality control and filtering, and statistical modeling are presented in the eAppendix in the Supplement.

The researchers then found that these same genes carry an additional risk for a phenomenon called spreading depolarization, a slowly - progressing, temporary electrical blackout of a region in the brain.

«Manyfold more genes were regulated in the resilient animals than in the susceptible animals across several brain regions,» says Eric Nestler, director of The Friedman Brain Institute at Icahn School of Medicine at Mount Sinai.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

He also suggested that «there is a connection» between Bt cotton, a GM product that includes genes from Bacillus thuringiensis (Bt) to make it pest - resistant, and farmers» suicides, referring to thousands of farmers who have committed suicide in the last few years due to indebtedness, mostly in cotton growing regions.

In a three - stage meta - analysis, Harvard University neurologist Clemens Scherzer and his collaborators analyzed gene expression in 410 samples taken from patients that either had symptomatic or asymptomatic Parkinson's or were healthy, including 185 samples of substantia nigra — a midbrain region where dopamine neurons are particularly susceptible to degeneratioIn a three - stage meta - analysis, Harvard University neurologist Clemens Scherzer and his collaborators analyzed gene expression in 410 samples taken from patients that either had symptomatic or asymptomatic Parkinson's or were healthy, including 185 samples of substantia nigra — a midbrain region where dopamine neurons are particularly susceptible to degeneratioin 410 samples taken from patients that either had symptomatic or asymptomatic Parkinson's or were healthy, including 185 samples of substantia nigra — a midbrain region where dopamine neurons are particularly susceptible to degeneration.

Of the genes involved in Parkinson's disease that are present in indicated regions, the strategy captured all but one.

By using the strategy, he and his team were able to filter down the thousands of genes in these sections to an average of two per region.

The SRY (sex - determining region Y) gene on the male's Y chromosome orchestrates the formation of the testes, while the gonadal precursor will differentiate into an ovary by default (in the absence of the steroids produced by the testes).

This region of homologous is encoded by eight contiguous exons in each respective gene.

The tests especially differ in that they examine different regions of the viral gene.

The researchers then examined a number of DNA variants in the protein production - control region of the bellwether gene in cell cultures.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

Comparisons of the Neandertal genome to the genomes of five present - day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development.

The direct methylation of the DNA changes the gene expression permanently if it takes place in the control regions of genes (so - called CpG islands), that have been made accessible by the modification of the histones.

«The interesting thing is that when we looked the same dog genes in human breast cancer, epigenetic aberrations occur in the same regions of DNA.

«The IMM teams showed clearly that the gene was switched on only in hypoxic regions,» says Sue Kingsman, the research director of Oxford BioMedica.

The result is that individuals with the most common form of the disease have a total of three copies of all the genes in this region.

Finally, the team identified a network of genes in these regions that exhibit changes in expression when the normal boost from serotonin is lacking, and these changes depended on how long the drug was given.

Further molecular biological studies by the scientists demonstrated that methylation in the non-coding region of the Igfbp2 gene contributes to less IGFBP2 synthesis.

We did not find any evidence for a so - called «positive selection» but instead found that many gene variants linked to schizophrenia reside in regions of the genome in which natural selection is not very effective in the first place.

If it is true that epigenetic changes to genes active in certain regions of the brain underlie our emotional and intellectual intelligence — our tendency to be calm or fearful, our ability to learn or to forget — then the question arises: Why can't we just take a drug to rinse away the unwanted methyl groups like a bar of epigenetic Irish Spring?

She speculates that the culprit may be a mutation located in a genome region that regulates activity of the IL - 33 gene.

«Genetics researchers close in on schizophrenia: 50 new gene regions that increase risk of developing schizophrenia.»

They lie in a region of chromosome 5 that sits squarely between two genes that produce cell - adhesion molecules, which govern how neurons connect to each other.

«By either skipping a mutation region or precisely repairing a mutation in the gene, CRISPR - Cpf1 - mediated genome editing not only corrects Duchenne muscular dystrophy mutations but also improves muscle contractility and strength,» said co-author Dr. Rhonda Bassel - Duby, Professor of Molecular Biology and Associate Director of the Hamon Center for Regenerative Science and Medicine.

Much like the association between BRCA gene mutation and the risk for breast cancer in women changed the approach to treatment / prevention, the identification of the Kallikrein 6 gene region may change the course of prostate cancer care through a blood test developed by the Lunenfeld - Tanenbaum Research Institute.

When oxygen is scarce, however, HIF - 1α starts to accumulate and turns on the expression of a host of genes that assist in promoting and increasing oxygen delivery to hypoxic regions.

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

Of the nearly 7,000 genes in the mycobacterial genome, one region spanning just 6 genes appears to be key in determining whether a mycobacterial strain will be a donor or recipient when it comes to mating.

But in a closer study of 73 families researchers found a region of genes on chromosome eight in those with perfect pitch and from European ancestry.

In the region surrounding the bead, the Barx - 1 gene — required for the development of molars — was dormant, evidence that BMP4 inhibits molar growth.

The investigators also found that the key difference between the two groups lies in the genes involved in production of the bacterium's outer coat, the primary region that interacts with the human immune system.

In mice, they deleted four ultraconserved elements — individually and in various combinations — that lie within regions of DNA that also contain genes important in brain developmenIn mice, they deleted four ultraconserved elements — individually and in various combinations — that lie within regions of DNA that also contain genes important in brain developmenin various combinations — that lie within regions of DNA that also contain genes important in brain developmenin brain development.

With a diameter in the region of a micrometer and a genome incorporating more than 1,100 genes, these giant viruses, which infect amoebas of the Acanthamoeba genus, had already largely encroached on areas previously thought to be the exclusive domain of bacteria.

In several groups of people, a gene variant allowing the lactase, the enzyme breaking down the sugar in milk, to persist into adulthood became common about 5000 to 7000 years ago, when humans were herding cattle — as evidenced by this rock painting of domestic cattle in the Jebel Acacus region of the Sahara desert in LibyIn several groups of people, a gene variant allowing the lactase, the enzyme breaking down the sugar in milk, to persist into adulthood became common about 5000 to 7000 years ago, when humans were herding cattle — as evidenced by this rock painting of domestic cattle in the Jebel Acacus region of the Sahara desert in Libyin milk, to persist into adulthood became common about 5000 to 7000 years ago, when humans were herding cattle — as evidenced by this rock painting of domestic cattle in the Jebel Acacus region of the Sahara desert in Libyin the Jebel Acacus region of the Sahara desert in Libyin Libya.

Part of this will involve extensive breeding programs (which work better in desert regions than in jungles, where there are lots of wild bees messing up the gene pool) and part will involve educating beekeepers and fighting a stereotype that African bees are always bad and European ones good.

Tallying the genes that were most perturbed by loss of Lef1 in this brain region revealed that over 20 were involved in mood disorders like depression and anxiety.

One end of the boy's swapped DNA lodged itself in the same region that the Oxford team had identified in the West London family, right in the middle of the FOXP2 gene.

This means that a group of risk genes is connected with a reduction in the size of a critical region of the brain before the disorder manifests itself.

The team integrated three, complementary gene sequencing approaches to look for mutations in tumor cells from SS patients: whole - genome sequencing in six subjects, sequencing of all protein - coding regions (exomes) in 66 subjects, and comparing variation in the number of copies of all genes across the genome in 80 subjects.

To develop a comprehensive view of astrocyte gene expression, the duo used the technique in four very different areas of the mouse brain: two regions of the cortex and the hypothalamus and cerebellum.

Another doubled - up region contains enhancers that turn on some genes in the cerebellum, a part of the brain that coordinates movement, speech and performs other important functions.

A third highly associated region encompasses a cluster of genes that play a role in ultraviolet (UV) response and DNA damage repair.

They used a somewhat bizarre technique in which two mice were sutured together in such as way that they shared a circulatory system (known as parabiosis), and found old mice joined to their youthful counterparts showed changes in gene activity in a brain region called the hippocampus as well as increased neural connections and enhanced «synaptic plasticity» — a mechanism believed to underlie learning and memory in which the strength of neural connections change in response to experience.

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).