Sentences with phrase «genes in those mice with»

Northwestern Medicine scientists have identified a small RNA molecule called miR - 182 that can suppress cancer - causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor.

When researchers deleted the gene in mice with various liver injuries, they found that the livers replaced tissue mass quicker and showed reduced fibrosis in response to chemical injury.

Yin then delivered that alongside guide RNAs packaged separately in AAV to fix broken genes in mice with liver disease.

In 2016, the research team spotted mice that sleep for extraordinarily long periods and ones that have extraordinarily short REM sleep in a sample of about 8,000 specimens, and discovered mutations of particular genes in those mice with unique sleep patterns.

Not exact matches

Bird and his colleagues created mutant mice with a roadblock in the Mecp2 gene that prevented it from being expressed.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellIn experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellin the face of rising TNF - alpha signals than normal cells.

The study coupled gene therapy that excited visual neurons in the eyes with stimulation — a swirling black - and - white grid placed in front of the mice.

A new mouse model of a genetically - linked type of autism reveals more about the role of genes in the disorder and the underlying brain changes associated with autism's social and learning problems.

In 1997 Joseph Takaha - shi of the Howard Hughes Medical Institute at Northwestern University and his colleagues isolated a gene they called Clock that when mutated yielded mice with no discernible circadian rhythm.

Twelve transgenic piglets endowed with a mouse UCP1 gene were better able to maintain their body temperature than their unmodified counterparts when they were exposed to cold for a 4 - hour period, the authors report today in the Proceedings of the National Academy of Sciences.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Jiang said autism researchers worldwide could use the mouse model to study ways to compensate for the gene and improve symptoms in people with autism spectrum disorders and Phelan - McDermid Syndrome, a more profound developmental condition caused by mutations to SHANK3 and other genes in chromosome 22.

These four genes and their proteins constitute the heart of the biological clock in flies, and with some modifications they appear to form a mechanism governing circadian rhythms throughout the animal kingdom, from fish to frogs, mice to humans.

So Sandra Ryeom at the Children's Hospital in Boston and colleagues bred mice with three genes to find out if an extra copy gave them extra protection against cancer.

When the researchers paired female mice treated with the gene therapy with males, the females were still able to become pregnant — and have healthy babies — within the first six weeks, because of those follicles that had already started growing in the ovaries.

With a single local injection of the USH1G gene just after birth, the scientists observed a restoration of the structure and mechanosensory function of the inner ear hair bundles — profoundly damaged before birth -, resulting in a long - term partial recovery of hearing, and complete recovery of vestibular function in these mice.

Normally, to achieve such a rapid evolutionary shift, a species needs to start with an alternative version of a gene already in circulation, giving natural selection more to work with, but in deer mice the new version of Agouti spread rapidly from a standing start.

In the study, researchers worked with a mouse model that has a debilitating mutation on one of the exons of the dystrophin gene.

The team found that humans are equipped with tiny differences in a particular regulator of gene activity, dubbed HARE5, that when introduced into a mouse embryo, led to a 12 % bigger brain than in the embryos treated with the HARE5 sequence from chimpanzees.

Using a novel form of gene therapy, scientists from Harvard Medical School and the Massachusetts General Hospital have managed to restore partial hearing and balance in mice born with a genetic condition that affects both.

By combining each mouse's genome, phenome, proteome and metabolome, the scientists were able to identify a particular gene, located on their chromosome 2, and whose presence plays an important role in the development of type 2 diabetes «The mice with a high - fat diet are more or less likely to develop diabetes depending on whether this gene is active or not,» said Evan Williams, LISP PhD student and the article's co-first author.

Mice born with extra copies of a human gene develop learning defects that may resemble those in Down syndrome.

They started with pairs of fat yellow mice known to scientists as agouti mice, so called because they carry a particular gene — the agouti gene — that in addition to making the rodents ravenous and yellow renders them prone to cancer and diabetes.

Base oxidation regulates gene activity In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of micIn cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of micin Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of micin embryonic stem cells of mice.

Finally, mice in which the Hand2 gene was specifically deleted in the endometrium developed precancerous endometrial lesions with age.

To determine if defects in the atrial natriuretic peptide (ANP) system can cause hypertension, mice were generated with a disruption of the proANP gene.

Like the per gene, the new genes — dubbed RIGUI in humans and m - rigui in mice — are turned on and off in a daily cycle and may work with other genes to generate the oscillating mechanism that runs the internal clock.

Scientists had been searching in vain for such a gene since 1994 when Rockefeller University scientist Jeffery Friedman found that lab mice with a specific genetic mutation fail to produce leptin and as a result have uncontrollable appetites, and become huge.

Since patients (and mice) with Usher 1c also have balance problems caused by hair - cell damage in the vestibular organs, the researchers also tested whether gene therapy restored balance.

In Martin's view, the result strongly suggested that the patients had inherited the silenced gene from one of their parents, like the case with agouti mice.

Nadeau stumbled upon one study, in mice, describing how environmental factors can tag Foxp3 with chemical markers that tell T - cell precursors to switch the gene on or off.

The first clue that digits and penises might be birds of a feather came in 1991, when a team led by developmental biologist Denis Duboule of the University of Geneva and Pierre Chambon of the Institute for Genetics and Molecular and Cellular Biology in Strasbourg, France, found that some mice with a mutated gene, called hoxd13, had abnormally small digits and malformed penises.

As expected, the mice carrying the mutated gene had far fewer vocalizations, with longer gaps between «speech» compared with their unmodified littermates — Gnptab mutant mice had about 80 vocalizations compared with 190 in the nonmutant mice.

Brueckner's group looked for gene defects in two strains of mice with situs inversus, a mutation in which the heart, lungs, and other organs are inverted, like a mirror image.

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

Ronald Kahn and his colleagues at Harvard Medical School in Boston compared gene expression in brain samples from mice with type 1 or type 2 diabetes against those of healthy mice.

They destroyed the T cells in 12 mice, five of which received marrow cells from normal mice while seven received marrow from mice with a defective Fas - ligand gene.

Mineral deposits and bone formation around toe joints of mouse with mutation in the ank gene (mutant foot shown on right, normal skeleton on left).

Diamond's lab circumvented this problem by creating female mice that had a key interferon gene knocked out; in a second experiment, they treated pregnant animals with an anti-interferon antibody.

Even in mice with working LCN2 genes, infusions of the hormone reduced food intake, improved blood sugar levels and increased insulin sensitivity.

In their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other micIn their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other micin the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mice.

Last week, the company reported that it managed to disable the TTR gene in the livers of mice, reducing levels of the protein by 97 per cent with no signs of any ill effects.

Sensory hair cells in the cochlea of a Beethoven mouse treated with TMC2 gene therapy.

The control mice, with all genes intact, should have lost sight as photo - receptors — the light - sensitive cells in the retina — died.

Global gene expression studies found that the LPA - treated mice shared many similar molecular markers as those found in humans with schizophrenia.

First author Kim Martinod, a graduate student in the Immunology Graduate Program at the Harvard University Medical School, found that, in response to vein constriction, these «rescued» mice now could function normally, forming clots as efficiently as mice with a functioning Pad4 gene, demonstrating that the Pad4 gene did produce a functioning PAD4 enzyme in these white blood cells to regulate blood clotting.

In one of their experiments, team members compared mice with a normally functioning Pad4 gene to mice with a defective gene.

In a study published earlier this year, Jiang and other collaborators at Duke described a mouse model of autism in which they deleted a prominent autism gene called SHANK3, which is mutated in 1 percent of people with the disordeIn a study published earlier this year, Jiang and other collaborators at Duke described a mouse model of autism in which they deleted a prominent autism gene called SHANK3, which is mutated in 1 percent of people with the disordein which they deleted a prominent autism gene called SHANK3, which is mutated in 1 percent of people with the disordein 1 percent of people with the disorder.

When researchers suppressed the ARF gene in mole - rat cells during the reprogramming process to iPSCs, the cells stopped proliferation with sign of cellular senescence, while the opposite happens with mouse cells.

In humans and mice, the gene is associated with height, face development and other traits.