LMU researchers have shown that patterns of activity of certain
genes in vertebrate embryos correlate with differences in the length of the neck region.
Prof Bentzen from Dalhousie University said: «Although this study focused on MHC
genes in vertebrates, the evolutionary dynamics described in it likely apply to other gene families, for example resistance genes and those which prevent self - fertilization in plants (self - incompatibility loci) that are caught up in their own evolutionary races.»
In addition to Otop1, there are two other related
genes in vertebrates (Otop2 and Otop3), and this gene family is represented in the fruit fly Drosophila melanogaster.
Not exact matches
On closer inspection, however, the
gene we had discovered
in vertebrates proved not to be a retrovirus
gene at all.
It appears the
vertebrate src
gene has survived long periods of evolution without major change, implying that it is important to the well - being of the species
in which it persists.
Some researchers thought that these organisms, which arose after bacteria but before
vertebrates, simply lost the
genes in question at some point
in their evolutionary history.
Several of the network
genes Volkan and her team identified have counterparts
in humans and other
vertebrates, which suggests the same basic mechanism could be at work
in building the nervous system
in other animals too.
Before the consortium came together, he had participated
in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the additional sequencing and analysis work that would be required to identify
genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000
vertebrate species.
All land
vertebrates carry a version of the FOXP2
gene, so some of the Oxford researchers then teamed up with colleagues from the Max Planck Institute for Evolutionary Anthropology
in Germany to analyze what is unique about the variant
in humans and to track how the
gene had evolved
in our ancestors.
«Given the similarities
in the molecules and the mechanisms involved
in limb development
in vertebrates and invertebrates, the fly is a very useful genetic model
in which to identify new
genes that potentially participate
in limb development
in vertebrates and their possible association with congenital diseases,» says Ana Ferreira, who has participated
in the study.
He explains that «we are the first to show these similarities between
gene activation
in diapause and aging
in vertebrates.
«We have already found several
gene types that are dramatically expanded
in the octopus relative to other
vertebrates, and we think they play a critical role allowing a new level of neuronal complexity to be reached
in invertebrates,» he said.
The MHC is a family of
genes found
in all
vertebrates that encodes vital proteins
in the immune defense system.
One
gene cluster connected with the development of the pharynx
in vertebrates and acorn worms is particularly interesting.
TheCiona genome contains ∼ 16,000 protein - coding
genes, similar to the number
in other invertebrates, but only half that found
in vertebrates.
They compared 146
genes in many chordates, including hagfish and lamprey (considered the most primitive
vertebrates) and larvaceans, which are sea - faring relatives of sea squirts.
«MHC
genes are an important line of defence
in the immune system
in vertebrates, including humans.
In the course of their research, however, the scientists discovered that the nerve net of the embryonic sea anemone is formed by a set of neuronal genes and signal factors that are also found in vertebrate
In the course of their research, however, the scientists discovered that the nerve net of the embryonic sea anemone is formed by a set of neuronal
genes and signal factors that are also found
in vertebrate
in vertebrates.
Similarly, the
gene for blue eyes codes for paler skin coloring
in many
vertebrates and hence might have piggybacked along with lighter skin.
«Our hypothesis is that structures conserved
in RNA are like a common template for regulating
gene expression
in mammals — and that this could even be extrapolated to
vertebrates and less complex organisms.»
... The FOXP2
gene has been around for a very long time, found
in similar form
in distantly related
vertebrate species, and it may be important not only for brain development and function but also
in other tissues.»
The team also compared the 7442
genes found as single copies
in both the cobra and the python with the same
genes in all other land
vertebrates sequenced so far.
In recent years, scientists have found that in vertebrates, including mammals, the earliest stages of segmentation are governed by a key set of genes, headed up by the so - called Notch gen
In recent years, scientists have found that
in vertebrates, including mammals, the earliest stages of segmentation are governed by a key set of genes, headed up by the so - called Notch gen
in vertebrates, including mammals, the earliest stages of segmentation are governed by a key set of
genes, headed up by the so - called Notch
gene.
Schoppmeier and his colleagues are now trying to determine whether Notch and related
genes turn on and off
in the same fashion
in early spider embryos as they do
in vertebrates.
That included several
genes linked to novelty - seeking
in vertebrates, such as receptors for the neurotransmitters dopamine and glutamate.
One of those
genes, ALX1, is involved
in the facial development of
vertebrates, including fish and mammals.
After removal of similar viral genomes, bootscan plots of the whole genome and individual
genes from a subset representing human / simian adenoviruses
in species A — G and all non-primate
vertebrate adenoviruses were generated.
Scientists think that this family evolved by
gene duplication, branch by branch, from a single ancestor present
in primitive
vertebrates.
In vertebrates,
gene content has remained relatively constant, while the fraction of non-coding DNA varies drastically [1 — 3].
Howard Hughes Medical Institute researchers have harnessed a mobile
gene from the cabbage looper moth and modified it for routine use to determine the function of
genes in mice and other
vertebrates...
This molecule brings a revolutionary technology platform for genetic engineering
in vertebrates, including
gene discovery
in model species and for therapeutic transgene delivery for possible human applications.
The result was the discovery of three new mammalian
genes - known as sonic, Indian, and desert hedgehog - and the realization that the proteins they coded accounted for a significant proportion of all developmental interactions known to occur
in the
vertebrate embryo.
«It was exciting to see that half of the domestication signals
in the genome point to
genes that have to do with brain development and function», says professor Kerstin Lindblad - Toh, senior author and director of SciLifeLab Uppsala, and scientific director of
vertebrate genome biology at the Broad Institute.
Their preservation
in the zebrafish allows us to visualize
in this transparent genetic
vertebrate model whether these variants are just neutral or if they disrupt the regulation of one the neighbor
genes, possibly revealing the actual
gene affected
in AMD human patients.
Biased
gene conversion and GC - content evolution
in the coding sequences of reptiles and
vertebrates.
A new study from SciLifeLab / Uppsala University published
in PLOS ONE shows that
genes crucial for vision were multiplied
in the early stages of
vertebrate evolution and acquired distinct functions leading to the sophisticated mechanisms of
vertebrate eyes.
New students with interests
in molecular genetics,
gene regulation, and developmental biology
in both invertebrate and
vertebrate models are welcome to enquire about any of the following projects listed below.
In vertebrates, 9 - amino acid containing peptides in the vasopressin / oxytocin family all evolved from a common ancestral molecule, vasotocin, in which a gene mutation gave rise to the mammalian homologue, vasopressi
In vertebrates, 9 - amino acid containing peptides
in the vasopressin / oxytocin family all evolved from a common ancestral molecule, vasotocin, in which a gene mutation gave rise to the mammalian homologue, vasopressi
in the vasopressin / oxytocin family all evolved from a common ancestral molecule, vasotocin,
in which a gene mutation gave rise to the mammalian homologue, vasopressi
in which a
gene mutation gave rise to the mammalian homologue, vasopressin.
To test a possible homology of these cells with the chordamesoderm, we chose a chordamesoderm - specific
gene set according to the following criteria: (i) specificity — their combined expression uniquely defines the chordamesoderm; (ii) conservation — their chordamesoderm expression is conserved
in at least three of four
vertebrate species; and (iii) function — they have proven essential for chordamesoderm development or signaling.
Gene duplications and subsequent mutations also led to the evolution of numerous sister nonapeptides across
vertebrates, including isotocin
in teleost fish and oxytocin
in mammals.
The length of the loop is at least 8 nucleotides long; there is no apparent maximum
in loop length, even
in organisms possessing only a single Dicer
gene, contra (6), even though most taxa like
vertebrates with single Dicer
genes never show loop lengths greater than ~ 40 nucleotides.
Another study, published
in Current Biology, highlights the complexity of the regulatory systems involved
in organism reproduction through the study of a
gene that is essential for meiosis
in vertebrates, but not Drosophila.
Although none of the
genes were exclusively expressed
in the annelid mesodermal midline, their combined coexpression was unique to these cells (implying that mesodermal midline
in annelids and chordamesoderm
in vertebrates are more similar to each other than to any other tissue).
This hypothesis was recently confirmed by the team of Abalo and Larhammar
in a detailed study on the visual opsin
gene family analysing a broad range of
vertebrate species.
They report that the
genes encoding the different subunits of PDE6
in cones and rods arose from ancestral
genes that duplicated
in the early
vertebrate genome doublings, and further expanded
in teleosts due to the extra genome duplication that took place
in this lineage.
The researchers discovered striking differences from other invertebrates, including widespread genomic rearrangements and a dramatic expansion of a family of
genes involved
in neuronal development that was once thought to be unique to
vertebrates.
After receiving a PhD
in molecular genetics and
gene silencing from Pierre and Marie Curie University Paris, I joined as a postdoc the laboratory of Frederic Rosa at Ecole Normale Superieure Paris to investigate the genetic basis of
vertebrate development.
Altogether, the data presented
in this study reinforces the evolutionary importance of the two rounds of whole genome duplication that occurred
in the
vertebrate ancestor and sheds light on the differential behaviour of
gene duplicates that arose
in these events.
Interestingly, they also identified another ancient
vertebrate gene copy, which they named PDE6I, and has been lost
in amniotes.
... According to a review by Lovich and Ennen (2013), the construction and operation of wind farms have both potential and known impacts on terrestrial
vertebrates, such as: (i) increase
in direct mortality due to traffic collisions; (ii) destruction and modification of the habitat, including road development, habitat fragmentation and barriers to
gene flow; (iii) noise effects, visual impacts, vibration and shadow flicker effects from turbines; (iv) electromagnetic field generation; (v) macro and microclimate change; (vi) predator attraction; and (vii) increase
in fire risks.