Not exact matches
In the first study, the researchers have used technologies at the SNP&SEQ Technology Platform at SciLifeLab to compare
genes from healthy
dog individuals with
genes from
individuals with breast cancer.
The future availability of pets, the perpetuation of the
dog fancy, the health of the
individual dogs and the
gene pools of the breeds that we love may all depend on keeping a few more
dogs intact!
Even though pet
dogs of these breeds rarely fulfill their original purposes these days,
individuals still carry their ancestors» DNA in their
genes, which means that members of a particular breed might be predisposed to certain types of aggression.
Genotyping - the process of screening
individual dogs to identify the specific
gene and the specific error (mutation) in a
gene that causes a disease.
In summary,
dog DNA testing is not based on
individual genes, but on «snips» which can carry similarities to other breeds that look nothing like one another.
I think the flaw in the
genes vs how you raise them discussion is neither of them can tell you about the
individual dog in front of you.
The
dog's genome of 19,000
genes has been mapped, but how each of these
individual genes is expressed is still an open question.
Most breeders, should they breed for any length of time, may expect to encounter it at some point, as it has been known to affect
individual stud
dogs that have been used extensively and which form corner stones of the current Bull Terrier
gene pool.
A clinically normal
dog from a litter that had one or no
individuals affected with hip dysplasia (which is a polygenic disorder) is expected to carry a lower amount of liability
genes than a
dog with a greater number of affected littermates.
In identifying a
dog's liability for carrying defective
genes for a polygenic disorder, the breadth of the pedigree (that is, consideration of all siblings of
individuals in the pedigree) is more important than the depth of the pedigree (consideration only of parent - offspring relationships.)
If, at some point in a breed's history, a particular sire or line of
dogs becomes predominant, inherited problems may start to arise seemingly out of nowhere simply because attempts to concentrate the desirable
genes of select
individuals can inadvertently bring together whatever undesirable
genes are present.
It tended toward greater heterozygosity — a mix of
gene versions — within
individual dogs, maintained genetic diversity in the breed, and therefore lessened the likelihood that bad
genes for things like eye disease would match up.
A risk factor
gene increases the probability that the
individual will develop disease, but not every
dog that has the disease - causing mutation will become ill.
This area becomes a bit more gray, because while there is a very good argument for not breeding close relatives of affected and carrier
dogs, we also can not afford to eliminate all
dogs in the
gene pool who meet this criterion — to do so would risk further constriction of the
gene pool to the point where the remaining «epilepsy - free»
individuals might have higher - than - normal frequency for
genes that contribute to some other genetic disorder.
How many of these
genes a
dog inherits determines the severity of the disease in an
individual dog.
Dogs testing in the abnormal range were generally considered affected with vWD and at risk for transmitting an abnormal vWF
gene to their offspring, and in some
individuals for expressing an abnormal bleeding tendency.
Since hip dysplasia is a polygenic disorder controlled by several
gene pairs, the disease affects
individual dogs due to different genetic combinations.
A
dog with two variant copies of the MLPH
gene will have a blue, charcoal, Isabella (lilac) or fawn coat color depending on the other coat color
genes present in the
individual.
Recessive genetic disorders (such as deafness) are only expressed as full diseases when an
individual dog carries two defective copies of the
gene.
In all
dog breeds, or all people, there will probably be 10's to 100's of
individual genes involved in primary epilepsy.
Previous studies indicate that some inherited disorders do not have significantly different prevalence across both the purebred and mixed - breed
dog populations [6] which may represent ancient disease liability
genes that preceded breed formation that are now distributed throughout the canine population as a whole or reflect recent purebred contributions to mixed - breed
individuals.
But that's not the case for purebred
dog breeds, where genetically similar
individuals are intentionally mated, increasing the concentration of disease
genes.