Sentences with phrase «genes into brain cells»

Inserting genes into brain cells may one day offer doctors a way to slow, or even reverse, the damage from degenerative neurological disease

«We're looking at bacteria that make magnetic nanoparticles, so we can insert their genes into brain cells in the same way,» Pralle says.

Not exact matches

She demonstrated that early experience leads to lasting changes in the molecular structure of the brain and discovered a gene involved in the spread of brain cancer cells into healthy brain tissue.

Another gene, PCDH15, plays a role in the hair cells» ability to convert sound into brain signals (Molecular Psychiatry, DOI: 10.1038 / MP.2014.8).

The lack of these genes in the neurons of active mice suggested that their brain cells did not immediately leap into an excited state in response to the stressor.

The first step in the process involves inserting into those brain cells a gene that makes a light - sensitive protein.

Then we convert images into a codelike pattern of light pulses that activates the modified genes and causes the output cells to fire off a message to the brain.

Nevertheless,» [the] study is very important because it demonstrates for the first time that we can use gene therapy to transform cells in the brain into ones that will secrete GDNF,» says Jeffrey Kordower, a professor of neurological sciences at Rush Presbyterian Medical Center in Chicago.

Some researchers have been trying an alternative route: engineering gene - delivery vehicles such as viruses to transfer neurotrophic - factor genes directly into brain cells.

In one such approach, researchers surgically remove brain cells, use viruses to transfer genes to the cells, and then graft them back into the animal's brain tissue.

For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disbrain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disbrain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disBrain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disBrain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disBRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disBRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.

Once the virus infected neurons with the heat - sensing gene, the researchers injected magnetic nanoparticles into the same brain cells.

We not only introduced the gene into specific brain regions of the mouse, but we could also direct it to specific cell types to test which ones played a role in regulating sociability.»

When they found a good candidate that could deliver genes to rat brain cancer cells, they filled the nanoparticles with DNA encoding an enzyme, herpes simplex virus type 1 thymidine kinase (HSVtk), which turns a compound with little effect into a potent therapy that kills brain cancer cells.

New insights into specific gene mutations that arise in this often deadly form of brain cancer have pointed to the potential of gene therapy, but it's very difficult to effectively deliver toxic or missing genes to cancer cells in the brain.

One of the genes involved in feeding the big brain, called SLC2A1, builds a protein for transporting glucose from blood vessels into cells.

In brain cells, Alu has repeatedly jumped into DNA associated with a gene called TOMM40.

Originally from algae, the gene makes a protein called channelrhodopsin - 2, which reacts to blue light by admitting ions into the brain cells, activating them in the process.

«By activating TLR3, the Zika virus blocks genes that tell stem cells to develop into the various parts of the brain.

In turn, hyper - activated TLR3 turns off genes that stem cells need to specialize into brain cells and turns on genes that trigger cell suicide.

However, in developing brain cells, the researchers found TLR3 activation also influences 41 genes that add up to a double whammy in this model — diminished stem cell differentiation into brain cells and increased cell suicide, a carefully controlled process known as apoptosis.

Recent research by neuroscientist Fred Gage and colleagues at the University of California (UC), San Diego, has shown that one of the most common types of jumping gene in people, called L1, is particularly abundant in human stem cells in the brain that ultimately differentiate into neurons and plays an important role in regulating neuronal development and proliferation.

These cells express many of the same genes expressed in brain cells — potentially providing a window into genetically - influenced differences in molecular responses to sex hormones.

Both teams used viruses to insert four genes comprising the transcription factors into skin cells, and demonstrated that brain, heart and other tissues could be created from cells created this way.

But studying these genes, many of which play roles in brain cell development, may ultimately help scientists understand how intelligence is built into brains.

In the case of gene editing, Verma is creating induced pluripotent stem cells (iPSCs) from patients by taking, for example, skin cells of patients, coaxing them back into an early stem cell state, and then providing conditions to make those cells develop into more complex brain, lung, prostate and breast tissues.

Other research at U-M is developing new options for treating brain cancer through immunotherapy — harnessing the immune system to attack cancer cells once an injection of a particular gene therapy is delivered into the brain tumor.

«This data allows classification of all human protein - coding genes into those coding for house - hold functions (present in all cells) and those that are tissue - specific genes with highly specialized expression in particular organs and tissues, such as kidney, liver, brain, heart, pancreas.

In a world - wide first, Chinese scientists cloned two monkeys by transplanting donor cells into eggs, they said on Wednesday, a feat that could lead to genetically engineered primates for drug testing, gene editing and brain research.

Recently, Dr. Ding achieved entirely gene - free chemical reprogramming, using only drugs to turn fibroblasts directly into brain cells.

The findings may even have implications for studying glioblastoma, a common brain cancer whose ability to grow, migrate and hack into the brain's blood supply appears to rely on a pattern of gene activity similar to that now identified in these neural stem cells.

Now researchers at UC San Francisco have taken the first step toward a comprehensive atlas of gene expression in cells across the developing human brain, making available new insights into how specific cells and gene networks contribute to building this most complex of organs, and serving as a resource for researchers around the world to study the interplay between these genetic programs and neurodevelopmental disorders such as autism, intellectual disability and schizophrenia.

The technique used in the study — optical stimulation of brain cells, or «optogenetics» — involves the insertion of a gene into parts of a brain to make them sensitive to blue light and then stimulating them with the light.

In a major breakthrough, Gladstone scientists transformed skin cells into heart cells and brain cells using a combination of chemicals and without adding external genes to the cells.

For example, if a human HAR — one that turned up the human gene a lot — was injected into a chimpanzee brain cell, it would function the same way by turning up the activity of the chimp neuron a lot.

In a revolutionary set of studies, Gladstone scientists pioneered a way to reprogram skin cells into heart cells and brain cells using only a combination of chemicals and without adding any external genes to the cells.

In a scientific first, Gladstone researchers have used chemical drugs to convert skin cells into heart cells and brain cells, without adding any external genes.