Told about a boy who had a portion
of his chromosome 13 inverted and who was the only
member of his
family with Tourette, State and his colleagues looked at three
genes close to the breakpoints
of the inversion.
The recent recognition that de novo lipogenesis might have relevance for lipid homeostasis in skeletal muscle stems from the realization that Sterol regulatory element binding protein - 1c (SREBP - 1c), a
member of the
family of transcription factors that regulate the expression
of genes involved in lipid storage in liver and adipose tissue, is also present in skeletal muscle at a level
close to that observed in the liver, 41,42... [M] ost fascinating are the very recent demonstrations that glucose alone (in the absence
of insulin) can stimulate de novo lipogenesis in skeletal muscle cells....