November 19, 2013 Study to identify functions of hypothetical genes in two infectious disease pathogens The National Institute of Allergy and Infectious Diseases (NIAID) has awarded the University of Chicago $ 4.4 million over five years to study
genes of unknown function in bacteria that cause plague and brucellosis.
Even those Mycoplasma cells with less than 500 genes, there are still 200
genes of unknown function in that cell.
Not exact matches
In the current study, researchers analyzed 48 ethnically diverse patients diagnosed with schizophrenia, looking at symptom sets in patients found to have rare or previously unknown changes in the DNA code of the four genes that disrupted brain functio
In the current study, researchers analyzed 48 ethnically diverse patients diagnosed with schizophrenia, looking at symptom sets
in patients found to have rare or previously unknown changes in the DNA code of the four genes that disrupted brain functio
in patients found to have rare or previously
unknown changes
in the DNA code of the four genes that disrupted brain functio
in the DNA code
of the four
genes that disrupted brain
function.
This bacterium's entire set
of genetic blueprints, its genome, consists
of only 473
genes, including 149 whose precise biological
function is
unknown, researchers report
in the March 25 Science.
They did, however, find copies
of genes related to CDR1, CDR2, and few others that encode other transporters associated with drug resistance — although the way they
function in C. krusei is
unknown.
The most common genetic mutation
in ALS and FTD is an abnormal repeated expansion
of the coding sequence within a
gene, C9ORF72, with
unknown function.
The
function of the encoded protein and why mutations
in the
gene cause a vestibular defect are
unknown.
The causative mutation was a repetition
of a piece
of non-coding DNA, a so called tandem repeat,
in a
gene with an
unknown function, named C9orf72.
Although these studies have generated vast amounts
of descriptive data, the
functions of most bacterial
genes in these collections remain poorly characterized or wholly
unknown.
The
function of the majority
of genes in the mouse and human genomes remains
unknown.
In addition, the core genome and pangenome of twelve P. aeruginosa strains was reported (10), as well as the accessory genome of these species that ranged from 6.9 - 18.0 % of the total genome, with most of these accessory genes found in mobile elements, and a majority of them with unknown or unclear functio
In addition, the core genome and pangenome
of twelve P. aeruginosa strains was reported (10), as well as the accessory genome
of these species that ranged from 6.9 - 18.0 %
of the total genome, with most
of these accessory
genes found
in mobile elements, and a majority of them with unknown or unclear functio
in mobile elements, and a majority
of them with
unknown or unclear
function.
Key to the project are lab and bioinformatics exercises that will give students the unique opportunity to work with Cold Spring Harbor Laboratory researcher David Jackson
in determining the cellular analysis
of Arabidopsis
genes of unknown function.
This study identified 1,317 distinct
genes found to be knocked out
in humans; many
of these
genes (e.g., APOC3, PLA2G7, LPA) are being pursued as therapeutic targets, whereas many others are novel
genes of unknown function.
About 64 percent
of the
genes have assigned roles
in the cell, while 20 percent match other hypothetical
genes with
unknown function.