Sentences with phrase «genes their study identified»

The group hopes to examine the effect in clinical trials in the future, and plans to look at the function of the other six genes their study identified.

Not exact matches

The method identifies gene sets that show evidence for positive selection in comparison with matched controls, and thus highlights genes for further functional studies.

Studies on genes, brain structures and hormones have failed to identify a clear link between, on one hand, differences at birth between the sexes and, on the other, particular behaviour.

He added that the method used in this study, called «network biology» — where computer systems are used to identify gene networks that work together to underpin disease — may also help find treatments for other conditions.

The team also looked at 56 genes that they had identified in a study of dogs with canine compulsive disorder, a condition in which dogs repeatedly chase their tails, pace back and forth, groom themselves or sucks things, sometimes for hours at a time.

According to the study, identifying the lncRNAs that play an unknown role in regulating genes involved in deafness will have an impact.

The study identified yet another mutation — albeit a rare one — in the SCARB1 gene, also associated with elevated HDL levels, that raised coronary heart disease risk by a whopping 80 percent.

«Identifying which of these candidate genes actually causes variation in responses to cold snaps will give us the potential to understand whether evolution to climate change can occur in both wild and domesticated animals, allowing us to better predict which species or breeds will be «winners» and «losers» and to better mitigate the effects of anthropogenic climate change on a wide range of organisms from beneficial pollinators to invasive pests,» said Theodore Morgan an associate professor of evolutionary genetics in the Division of Biology at Kansas State University and senior author of the study.

Researchers at the University of Maryland School of Medicine have identified a mutation in a fat - storage gene that appears to increase the risk for type 2 diabetes and other metabolic disorders, according to a study published online in the New England Journal of Medicine.

«Our studies are the first, to our knowledge, to identify a gene that plays a conserved role in aggression all the way from flies to humans,» explains Anderson, who is also a Howard Hughes Medical Institute investigator.

«One gene closer to regenerative therapy for muscular disorders: Study identifies gene that gets muscle cells to fuse together.»

A previous study authored by Millay in 2014 identified myomaker and its gene through bioinformatic analysis.

Predisposition to vascular disease was my focus here, using genetic epidemiological studies to identify novel polymorphisms in a range of candidate genes.

A study published June 1 by Nature Communications reports scientists identify a new gene essential to this process, shedding new light on possible new therapeutic strategies.

«The next step is to identify antibodies and small - molecule drugs that can successfully target Helios or genes in the Helios pathway,» says the study's lead author, Hye - Jung Kim, PhD, of Dana - Farber.

By studying these relationships, the researchers have discovered a new pathway to identify how genes influence disease, according to Boerwinkle.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Most of the rechristened genes were identified by geneticists studying the fruit fly; when equivalent genes were later found in the human genome, researchers simply continued using the name of the fruit fly gene to avoid confusion.

This study examined the genetic code of affected patients with schizophrenia and their healthy parents to identify newly occurring (sporadic) mutations that disrupted the four influential signaling genes in 31 percent of these patients.

A new study has identified a number of genes that are repressed at various time points after memory formation, providing important clues as to how long - term memories are formed.

A second study published in Biological Psychiatry, also led by Dr. Perlis, applied the new method in a proof - of - concept study to identify genes associated with psychiatric symptoms.

For example, we're funding research into faulty genes which make some men more likely to develop prostate cancer and studying how these genes could help doctors to identify patients who are more at risk.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

«A recent study identified over 100 genes associated with schizophrenia risk, but their functions are largely unknown,» said Yingwei Mao, associate professor of biology at Penn State and lead author of the study.

Now, in a study that looked at the genomes of more than 6000 people from Latin America, researchers have identified 18 genes that appear to influence hair traits, including the first ever to be associated with graying.

«Mutations responsible for cleft palate and related birth defects identified: Study of Amish and Saudi Arabian families finds mutations in HYAL2 gene that impact development.»

Before this new study, only a handful of genes related to baldness had been identified.

The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of schizophrenia and also found that some of the genes identified as increasing risk for schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability and autism spectrum disorders.

«We have identified the molecular mechanisms by which the Tat protein made by HIV interacts with the host cell to activate or repress several hundred human genes,» said Dr. Iván D'Orso, Assistant Professor of Microbiology at UT Southwestern and senior author of the study.

In 1993, geneticist Dean Hamer co-published a study claiming male homosexuality was at least partially genetic, and he identified the chromosome segment where one of the relevant genes was located.

Although it has always been believed that sponges are so simple than their responses to stimuli are minimal, the study identifies some genes involved in nerve conduction in more complex animals: «This proves that sponges» responses to environmental changes or physical stimuli may be more complex than it was thought,» underlines Ana Riesgo, who also participates in the project Actiquim, focused on chemical ecology in Antarctica.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

The study identifies a wide set of genes — previously associated with complex structures in higher animals — which were supposedly absent in sponges.

In a new study, researchers are taking joint biopsy tissue from patients at the start of a new therapy and then six weeks later to see if they can find a predictor gene sequence that will clearly identify which patients respond to a particular therapy.

Rudich says that the study enabled the researchers to identify a «signature» for each source of bacteria based on the prevalence of antibiotic resistant genes, which revealed whether the genes were local or imported from distant deserts.

«An even larger study would help start identifying specific genes with a higher level of confidence,» he said.

Studies seeking subtle signs of selection in the DNA of humans and other primates have identified dozens of genes, in particular those involved in host - pathogen interactions, reproduction, sensory systems such as olfaction and taste, and more.

Ongoing studies by investigators across the country, including Drs. Abraham Palmer and James MacKillop, who also participated in the conference, involve analysis of DNA and questionnaire responses from as many as 25,000 human subjects in order to identify specific genes involved in delay discounting.

In this study, a team led by Panos N. Papapanou, DDS, PhD, professor and chair of oral, diagnostic and rehabilitation sciences at the College of Dental Medicine at CUMC, «reverse - engineered» the gene expression data to build a map of the genetic interactions that lead to periodontitis and identify individual genes that appear to have the most influence on the disease.

The study was the first of its kind to employ genome - wide reverse engineering to identify the gene pathways that contribute to periodontitis.

In a study exploring the molecules controlling osteoclast differentiation in the cancer setting, Ell et al. have identified miRNAs (microRNAs are small noncoding RNAs that regulate gene expression) whose levels were consistently down - or up - regulated in differentiating osteoclasts.

«A study covering a large number of subjects, like the one in 2015, makes it possible to identify the relevant genes across the entire population; but their variations have only a limited impact on individuals.

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

In the next phase of the study, we will examine and categorize the functions of the genes that we identified — not only in model organisms, but also in agriculturally and economically important crops such as corn.»

Although previous studies have found that a large percentage of hair colour variation is explained by heritable factors, previous genetic studies only identified a dozen or so hair colour genes.

«This is an exciting study of a very rare bone disorder that not only identified the responsible mutation in half of the patients, but uncovered fundamental information about the role of a cancer - related gene in the metabolic pathways of normal bone,» said study co-senior author Joan Marini, Ph.D., M.D., of NICHD.

Their studies identified thousands of genes showing population differences in transcriptional response to infection.

«Given the similarities in the molecules and the mechanisms involved in limb development in vertebrates and invertebrates, the fly is a very useful genetic model in which to identify new genes that potentially participate in limb development in vertebrates and their possible association with congenital diseases,» says Ana Ferreira, who has participated in the study.

In a recent series of studies researchers identified a previously unknown critical role for a potential cancer causing gene, Bcl3, in metastatic breast cancer.

To further identify the role of TAZ, the research team studied breast tissue at different stages of development using two groups of mice: a control group with the TAZ gene and an experimental group of knock - out mice with the TAZ gene deleted.