The team also carried out a so - called metagenomic analysis, in which the genomes from all organisms in a sample are sequenced collectively; the great majority of
genes they found coded for proteins never seen before.
Not exact matches
The researches
found that the transgene was inserted into an active region of the genome, thereby disrupting the
coding sequence and ultimately the function of the plants own OsAux1
gene.
Epigeneticists have
found that our cells carry a type of memory of the experiences of our ancestors — not only that, but 95 % of our
genes aren't yet
coded at birth, dependent on nurturing and the environment to determine their fate.
This
finding came as a surprise since it was assumed that as a consequence of the evolutionary divergence between human and other animal viruses, the
genes that
code for LANA could not be switched.
In the current study, researchers analyzed 48 ethnically diverse patients diagnosed with schizophrenia, looking at symptom sets in patients
found to have rare or previously unknown changes in the DNA
code of the four
genes that disrupted brain function.
Recently he
found that eight of the youngsters have a defect in a
gene that
codes for a receptor protein called melanocortin - 4, known to regulate eating in mice.
The American cockroach has
genes that
code for more than 150 scent receptors and 500 taste receptors, the most
found in any insect so far.
Sequencing the genome of one such organism, King and her colleagues
found genes that
code for pieces of the same proteins used for the binding of cells and communication between cells in animals — functions that would be unexpected in such an organism.
Affected family members, the group
found, had inherited one or two defective copies of ZIC3, a previously unknown
gene that appears to
code for a transcription factor — a protein that switches other
genes on or off.
Several mutations were
found in
genes coding the machinery that makes mitochondrial proteins, and so would probably hinder mitochondria's ability to make the chemical fuel called ATP, which is used by normal cells.
Pruitt and his colleagues
found that these plants had somehow retrieved ancestral
code that allowed them to repair the mutant
gene.
There are several reasons why nobody before Shatz had
found genes coding for MHCI in normal neurons.
Not long after the HD
gene was isolated, studies led by MacDonald, also a co-author of the current investigation,
found that a variation in the number of CAG trinucleotide repeats within the HD
gene, which
codes for a protein called huntingtin, is the primary determinant of the age at which HD symptoms appear, with a greater number of CAG repeats associated with an earlier symptom onset.
Using genetic data from more than 36,000 people with a variety of autoimmune diseases, researchers
found that one genetic variant in the
gene that
codes for the TYK2 protein...
By comparing proteomic and RNA - sequencing data from people on different exercise programs, the researchers
found evidence that exercise encourages the cell to make more RNA copies of
genes coding for mitochondrial proteins and proteins responsible for muscle growth.
By deleting some of these «ultraconserved elements», researchers have
found that these sequences guide brain development by fine - tuning the expression of protein -
coding genes.
Researchers
found that kochia has evolved to have multiple copies of a
gene code that targets glyphosate.
For this reason, their
finding — that nearly half of the unmapped sequences contained in available genomic reference libraries, including many protein -
coding genes, were located in the centromeres — was unexpected.
The researchers have studied analyses of the genetic material of viruses
found in newly infected people and, in particular, the
gene env, which
codes for the protein envelope or «coat» around the virus.
Using next - generation sequencing to identify the underlying mutations causing these effects, the groups
found that the only common suspect was again the ap2 - g
gene — the
gene that
codes for producing the AP2 - G protein.
Analyses
found novel associations with three loci — regions of the genetic
code — and the disorder at
genes KANK4, LAMC1 and ATP1B1.
They looked specifically for
genes coding the major histocompatibility complex (MHC)-- a molecule
found on the surface of cells that acts as a crucial component of the immune systems of most vertebrates.
Working with cultures of respiratory tract cells, Elias's team
found that the
gene that
codes for il - 6 is inactive unless a protein known as nf - kb (nuclear factor - kappa beta) attaches to the
gene.
Dr. Ella Evron and Dr. Ayelet Avraham of the TAU - affiliated Assaf Harofeh Medical Center, together with Prof. Saraswati Sukumar of Johns Hopkins, have
found that «
gene regulation,» the process that shuts off certain parts of a cell's DNA
code or blueprint in healthy breast tissue cells, may also play a critical role in the development of breast cancer.
We
found 20
genes that distinguished motor neurons that innervate digit muscles from the others, and there's a strange
gene code involved in the cells» development.
«By sequencing all of the DNA that
codes for mRNA and ultimately, proteins, Dr. Amin and colleagues
found a single
gene that may account for as much as 4 % of the heritable risk for depression,» said Doctor John Krystal, Editor of Biological Psychiatry.
Already they have
found some promising results in a
gene that
codes for a brain enzyme called FAAH.
Jeremy Hall of the University of Edinburgh, UK,
found that a mutation in the
gene that
codes for the protein is linked to a higher risk of schizophrenia.
Pugh and Venters further validated their surprising
findings by determining that these non-
coding initiation machines recognized the same DNA sequences as the ones at
coding genes, indicating that they have a specific origin and that their production is regulated, just like it is at
coding genes.
Learning more about how synapses change their connections could help scientists better understand neurodevelopmental disorders such as autism, since many of the genetic alterations linked to autism are
found in
genes that
code for synaptic proteins.
TheCiona genome contains ∼ 16,000 protein -
coding genes, similar to the number in other invertebrates, but only half that
found in vertebrates.
According to Richard Durbin, who leads the project's informatics team, computer techniques seem to
find most of the
genes sequenced so far but frequently missed some pieces of them, particularly the short
coding regions that occur at the beginning of many nematode
genes.
An alteration in the neuregulin - 1
gene — a single change in one letter of the DNA
code for the protein — has been
found in families with schizophrenia and linked to late - onset Alzheimer's disease with psychosis.
We further investigated the source of the conflict in the protein -
coding genes (SM11) and
found that trees using all codon positions from the 10 % most compositionally homogeneous (low - variance) exons (n = 830) were most congruent with the c12 tree and, thus, more similar to the TENT than to the c123 tree (Figs. 2 and 6A; cladograms in fig.
The human genome — the sum total of hereditary information in a person — contains a lot more than the protein -
coding genes teenagers learn about in school, a massive international project has
found.
The team, which included members of the Health Science Center departments of medicine and biochemistry, investigators from the UT Southwestern Medical Center at Dallas and a group of collaborators from Austria,
found that the
gene that
codes the enzyme D2 - hydroxyglutarate dehydrogenase (D2HGDH) is mutated in a subset of cancers called diffuse large B - cell lymphomas.
Merely
finding genes, which make up only two per cent of the genome, amid the reams of DNA
code produced by sequencing will be hard enough.
In search of an explanation, the scientists combed through the African elephant genome and
found at least 40 copies of
genes that
code for p53, a protein well known for its cancer - inhibiting properties.
In about 70 percent of the cases, he
found a dislocation in a particular region of a certain chromosome, but at first he could not
find any protein -
coding gene responsible.
A massive study of twins
finds that facial recognition ability is
coded in our
genes — but few of those
genes also affect general intelligence
The number human protein
coding genes, which account for less than 2 % of the human genome, have recently been
found to number over 20,000.
They
found that while elite suppressors often have the rare set of
genes that
code for HLA - B, those
genes are «neither necessary nor sufficient» for controlling the virus.
A 2007 study at Harvard University and Germany's Max Planck Society
found a red - hair -
coding variant of hair - color
genes in 43,000 - and 50,000 - year - old Neanderthal remains.
When the chimp and human genomes are compared, some of the clearest cases of nucleotide differences are
found in
genes coding for transcription factors.
They
found that the initial stretch of either
gene coded for the part of the protein that was necessary for secretion.
Through closer investigation, he
found that the RNA sections that stuck around contained chemical
codes that act as stop signs, prematurely halting the translation of the RNA from these two
genes into proteins.
In 2000 Zuker and others
found some 30 different kinds of
genes that
code for bitter - taste receptors.
They
found 10 unique proteins and 23 microRNAs — short bits of RNA that don't
code for
genes — at increased levels in the vesicles.
They used CRISPR / Cas -9 to delete various sections of the Notch1
gene, and
found that deleting the section that
codes for the intracellular domain had no effect on permeability, while deleting the section that
codes for the tiny transmembrane domain (TMD) caused vessel leakage to increase under flow conditions.
The
gene - by - hormone interaction's effect on circuit function was
found only with one of two versions of the
gene that
codes for BDNF (brain - derived neurotrophic factor), a chemical messenger operating in the circuit.