Sentences with phrase «genes under selection»

The identified genes were attributed to four categories (metabolic genes, transmembrane proteins, shell matrix proteins and protease inhibitors) and are candidates for genes under selection in the context of an acidifying ocean.

Tomas Marques - Bonet of the Universitat Pompeu Fabra noted that studying gene flow between ancient humans such as Neanderthals, Denisovans and the ancestors of modern humans has revealed numerous genes under selection that affect disease and an individual's traits.

«We are finding that a lot of genes under selection in the cave fish are involved in metabolism,» says Suzanne McGaugh of the University of Minnesota, who studies the population genetics of the species and was not involved with the research.

Functional analyses indicate that MFSD12 encodes a lysosomal protein that affects melanogenesis in zebrafish and mice, and that mutations in melanocyte - specific regulatory regions near DDB1 / TMEM138 correlate with expression of ultraviolet response genes under selection in Eurasians.

«Those modern humans» selected genes under selection may prove central to a relevant process of domestication, given that these interactions may provide significant data on relevant phenotypic traits,» said Boeckx.

Not exact matches

«We found that chimpanzees, orangutans and gorillas do not show a significant overlap of genes under positive selection with domesticates.

«Our selection scans identified genes that were already known to evolve under strong selection in horses.

Under these conditions, natural selection may be favoring genes that confer resistance to disease, such as AIDS and malaria, or enhance reproductive fitness in other ways, researchers said in a report in Science.

When human genes apparently under selection were categorized using a software program that groups them according to biological function, they clustered into six different categories.

As a rule, the greater the linkage disequilibrium associated with a gene, the more likely that the gene has been under recent selection.

A companion paper published in BMC Evolutionary Biology by colleagues at the EPA lab in Narragansett, RI, that used a «candidate gene scan» approach — examining SNPs from 42 genes associated with the AHR pathway — also identified AHR2 as a gene that appears to be under selection and is likely to be involved in the resistance.

The malarial genes under the most intense selection pressure — those with the most variation, generated over a millennium - long cat - and - mouse game with the immune system's antibody response — are the ones that encode the identifying proteins on the surface of the parasite.

«Devastating de novo mutations in autism genes should be under strong negative selection pressure,» he explains.

We identified human X-linked genes whose gametologs have been pseudogenized or completely lost from the Y chromosome and inferred which evolutionary forces may be acting to retain genes on the Y. Although gene loss appears to be largely correlated with the suppression of recombination, we observe that X-linked genes with functional Y homologs evolve under stronger purifying selection and are expressed at higher levels than X-linked genes with nonfunctional Y homologs.

There are at least six genes that look to be under positive selection in cats that are associated with hearing capacity; we know this because mutations in these genes cause nonsyndromic recessive hearing loss or deafness.

I found that negative selection against new mutations and positive selection for new mutations shape broad patterns of genomic variation and that much of the genomic variation that actually affects gene expression is under negative selection.

At least 20 genes under positive selection in cats are associated with vision - related pathways, which fits with the importance of visual acuity for these natural - born hunters.

A different research group recently found that the Osiris gene cluster is under strong selection in an isolated population of the fly D. yakuba that has just begun adapting to a diet of poison - laden noni, another clue that learning more about these genes may be crucial for understanding OA resistance and this compelling model of ecological adaptation.

They searched in particular for genes under positive natural selection, and put those findings in context with what we know about cats relative to other carnivores.

Comparisons of these emergent species and other pathogenic fungi will enable evolutionary studies, revealing, for instance, fungal genes that are conserved or under selection and which could be important for drug resistance and virulence.

Yet despite this possibility of a partial redundancy of function with Dazl, mouse Boule has been maintained under purifying selection, further indicating that the presence of other DAZ family genes has had little impact on the functional constraint of Boule.

Typically, a fitness based selection such as a stress condition is used in these experiments and the processed sequencing data are used to identify genes required for fitness under the selection.

Three specific codon sites within the genes celA2b, katG and cyp138 were identified by MEDS as displaying significant evidence of evolving under directional selection influenced by HIV - 1 co-infection.

A common approach is to sort genes by gene ontology (GO)[9] category and speculate on their likely function, involvement in potential pathways, and reasons for being under selection.

The paucity of single nucleotide diversity among breeds is consistent with other studies (29 — 32) and stands in stark contrast to the abundance of coding repeat variation we found in these same genes known to be involved in the developmental processes under selection in the radiation in dog breed morphologies.

Culture — gene coevolutionary theory posits that cultural values have evolved, are adaptive and influence the social and physical environments under which genetic selection operates.