Sentences with phrase «genetic alterations affecting»

Finally, we are undertaking a vast mutational analysis of endocytic proteins in cancer, to define genetic alterations affecting the endocytic machinery.

Publishing in Nature, a recent study reports that genetic alterations affecting a part of the PD - L1 gene increases the production of the protein, allowing cancer cells to escape detection by the immune system.

Publishing in Nature, the study reports that genetic alterations affecting a part of the PD - L1 gene increases the production of the protein, allowing cancer cells to escape detection by the immune system.

Many of these genetic alterations affect the process of long term potentiation, a process where neurons that get stimulated at the same time have the connections between them grow stronger.

Not exact matches

Now, new research suggests changes at the epigenetic level — specifically alterations in proteins that affect gene expression, rather than genetic mutations — could be driving childhood ependymomas.

«We found genetic alterations in brain metastases that could affect treatment decisions in more than half of the patients in our study,» Dr Brastianos will say.

Later in life the genetic material can be changed by epigenetic modifications, i.e. chemical alterations of the DNA the affect the activity of the genes.

Importantly, this genetic alteration did not affect normal hematopoietic (blood) stem cells.

For instance, some of the genetic alterations found in the study occurred in families with one person severely affected by autism and others on the milder end of the spectrum, Dr. Scherer notes.

In the course of this work, he has pioneered several new approaches in the fruit fly that have had important implications for mammalian neurobiology, including: the demonstration that the fruit fly has a sleep - like behavior similar to that of mammals, studies of physiological and behavioral consequences of mutations in a neurotransmitter system affecting one of the brain's principal chemical signals, studies making highly localized genetic alterations in the nervous system to alter behavior, and molecular identification of genes causing naturally occurring variation in behavior.

Many medical - genetic syndromes show a clear connection between genetic alteration and typical facial gestalt [49], hence genes involved in affected individuals may also contribute to normal variations in facial shape.

a. Mechanism - guided therapeutic strategies for genetic alterations that affect the SWI / SNF chromatin remodeling complex in epithelial ovarian cancer (such as ARID1A mutation in clear cell and endometrioid subtypes of ovarian cancer, and CARM1 amplification / overexpression in high - grade serous ovarian cancer).

These alterations can change genetic expression, or even switch genes off, and may be part of the explanation of how maltreatment affects the developing brain.