Sentences with phrase «genetic animal model»
A unique strength of the TNC is our ability to study analogous phenotypes in rare genetic populations and the corresponding genetic animal models of disease.
http://www.childrenshospital.org/ Not exact matches
To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.
Using gene editing to create rodents that are ideal research models could narrow the genetic divide between humans and their animal stand - ins.
The identification of these genetic defects has fed back to create ever more realistic animal models of the diseases, as mentioned earlier for Huntington's disease.
While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.
Having a genetically identical, reliable animal model meant the most when an animal's genetic blueprints, or genomes, were hard to come by.
«Most previous research into ways of delaying the onset of HD symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in patients remains a huge assumption,» says James Gusella, PhD, director of the Center for Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH), corresponding author of the Cell paper.
Importantly, the development of a new animal model for Dravet syndrome based on reduced CHD2 expression might help to find effective treatments that could improve the lives of thousands of people suffering from Dravet syndrome and perhaps other genetic epilepsies.»
A simple and inexpensive zebrafish model of concussion, reported in eNeuro, reveals the genetic pathways underlying the animal's remarkable ability to regenerate injured brain tissue.
«Drug candidate stops extra bone growth in animal model of rare, genetic disease.»
To shed light on the mystery of Bornean elephant's origin, Chikhi and Goossens» team used genetic data analysis and computational modelling to study the past demographic history of these animals.
Ko is quick to note that these new findings do not warrant radical dietary changes in people with Crohn's: More studies, including more refined genetic analyses of fatty acids and Crohn's and testing in animal models, are needed.
Importantly, these devices also will open up new approaches to drug development not possible with animal models today, such as personalized medicines and development of therapeutics for specific genetic subpopulations using chips created using cells from particular patients.»
Mead believes ALS is ripe for AI and machine - learning because of the rapid expansion in genetic information about the condition and the fact there are good test - tube and animal models to evaluate drug candidates.
The most important advancement in medicine in the last 25 years was the development of genetic modeling in animals, enabling us to figure out how fundamental mechanisms of physiology and disease work, such as in bone loss.
But big data from genetic fingerprinting of animal DNA in a landscape combined with fine - resolution satellite data and sophisticated ecological models can.
«This is the first example of taking a genetic sequence and designing a drug candidate that works effectively in an animal model against triple negative breast cancer,» said TSRI Professor Matthew Disney.
The first genetic clues for slowing aging emerged from animal models in which the effect of individual genes on average life spans could be tested.
The discovery was made by developing a mouse model of the disease that enabled researchers to track which of 15 genetic groups — or subclones — of myeloma cells spread beyond their initial site in the animals» hind legs.
C.elegans has been used for decades as a model animal to study the genetic and molecular underpinnings of neurological disorders through a number of techniques including bio imaging, electrophysiology and behavior.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found that a type of genetic material called «microRNA» plays surprisingly different roles in the formation of memory in animal models.
Because M. lepromatosis can not be grown in the lab and animal models for this version of leprosy do not exist yet, the scientists used an infected skin sample from a patient in Mexico to obtain the bacterium's genetic material.
«Future studies on maternal smoking and other environmental, genetic, and epigenetic factors, as well as animal models, should allow identification of the biological mechanisms responsible for these associations.
However, the genetic techniques used to block Hhat in the laboratory are not possible with animal models or humans.
In a new project that began this month, Drs. Anuradha Ray and Wenzel were recently awarded a five - year, $ 8 million grant from the National Institute of Allergy and Infectious Diseases (NIAID), also part of the National Institutes of Health (NIH), to continue studying the immune response and genetic roots of severe asthma in 120 patients and in animal models.
Genetic modification in zebrafish models is cheap and easy, so authors point out that future research on these animal models will contribute to understand the molecular relationship that exists between the proteins involved in the physiopathology of megalencephalic leukoencephalopathy.
Future studies should investigate whether, or how, the genetic alterations that lead to this ASD animal model change the serotonin system, with the aim to provide possible insight into serotonergic deficits in human patients, the authors say.
They addressed this by conducting a series of molecular and genetic screens of developing hindgut tissues in animal models.
The team, including researchers from the Natural History Museum in London, quantified the anatomical and genetic differences between living animals, and established a timeframe over which those differences accumulated with the help of the fossil record and intricate mathematical models.
Examples of funding areas include but are not limited to molecular genetic analysis of relevant neural circuit assembly and function; genetic and epigenetic research; animal models created by genetically altering neural circuits; and testing of new chemical entities that might be used in animal models as exploratory treatments.
Dr. Parsons has provided similar insights into the mechanisms through which endocannabinoids modulate the rewarding effects of opiates, alcohol, and cocaine, and he is presently extending his evaluations of this stage of the addiction cycle to include animal models of commonly occurring genetic polymorphisms that are associated with problematic drug use and dependence in humans.
Professional Experience 1983 — 1986 Research / Teaching Assistant, Exercise Physiology, University of Texas, Austin TX 1986 — 1990 Assistant Instructor / Research Assistant, Cell Biology, Developmental Biology, and Vertebrate Physiology, University of Texas, Austin TX 1993 — 1994 Visiting Assistant Professor, Department of Animal Sciences, Oregon State University 1994 — 1996 Technical Services Advisor, Genetic Resources, The Jackson Laboratory, Bar Harbor ME 1996 — 1998 Manager, Technical Services, The Jackson Laboratory, Bar Harbor ME 1997 — 1998 Assistant Professor, Adjunct, New Mexico Highlands University, Las Vegas NM 1998 — 2000 Senior Technical Information Scientist, The Jackson Laboratory, Bar Harbor ME 2000 — 2002 Senior New Models Development Scientist, The Jackson Laboratory, Bar Harbor ME 2002 — 2004 Associate Director of Genetic Resources, The Jackson Laboratory, Bar Harbor ME 2004 — 2005 Associate Research Scientist, The Jackson Laboratory, Bar Harbor ME 2004 — 2009 Assistant Professor, Dept. of Biology, New Mexico Highlands University, Las Vegas NM 2009 — 2014 Associate Professor, Dept. of Biology, New Mexico Highlands University, Las Vegas NM 2014 — present Professor, Dept. of Biology, New Mexico Highlands University, Las Vegas NM
Researchers have established a strong genetic component for addictive behaviors through studying animal models, including laboratory mice.
Dr. Tarazi studies the behavioral, genetic, molecular, and cellular mechanisms that mediate the actions of dissimilar psychotropic drugs by using animal models that mimic the core symptoms of different neuropsychiatric diseases.
We have learned a fair amount from the neurologic genetic diseases, but we and others also studied these cells in the laboratory as well as in animal models of brain injury.
This network is composed of a central animal facility (PBES) and several technological platforms: production of mutant animals, vectorology and genetic analysis as well as infectious models analysis.
Taking advantage of fly genetics The research will combine the strength of the fly system (animals that are short lived but complex enough to model regenerative activity in vertebrates) with genetic studies in mice to understand the role of mTOR signaling in maintaining the health of adult stem cells in both species.
PHENOMIN - TAAM (The Transgenesis and Archiving of Animal Models) provides services for basic research, biomedical and pharmaceutical research covering the creation, transgenesis, health status monitoring, the cryopreservation, the revival, the genetic analysis and the functional imaging.
His lab develops isogenic human pluripotent stem cells and transgenic animals to model disease, with the goal of delineating novel approaches to influence outcomes for Huntington disease (HD) and Fragile X Syndrome (FXS), the most common genetic causes of dementia and intellectual disability, respectively.
Additionally, genetic modification or pre-conditioning of autologous cells to boost the levels of VEGF [4], ANG [5], and TGF -[6], all previously linked to alleviation of ALS symptoms, could potentially lead to an augmented response, although this must first be assessed in animal models, such as the SOD1 mice.
The role of new genetic pathways in cancer biochemistry (the genome mutation profiles), the identification of the key targets and their validation, as well as utilization of new knock - out or knock - in animal models for such studies are among topics that will be discussed.
To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.
The third webinar, and the final one will focus on animal models of obesity and diabetes, both talking about genetic models, as well as dietary models and how they are used in basic research, but also in pharmaceutical and biotech research.
Courses on animal model and genetic engineering tools for l'UMR - 911 of Pharmacy faculty of Aix - Marseille.
Dr. Ressler's lab focuses on translational research bridging molecular neurobiology in animal models with human genetic research on emotion, particularly fear and anxiety disorders.
In this way, in - depth immunological monitoring, genetic and proteomic analyses, and biomarker discovery from patient samples guides further laboratory investigation, where mechanistic studies can be designed and animal modeling performed.
Research efforts in each program span from bench - to - bedside, including basic / genetic, cellular, animal model, andhuman clinicalinvestigations.
Utilizing data collected from human clinical populations, Dr. Ressler and his team identify genetic traits and neural processes that may contribute to the underlying causes of these illnesses and provide novel targets for animal models research.
The dual appointment allows him to conduct experiments that compare genetic programming in the highly regenerative animals used as models at the MDI Biological Laboratory with genetic programming in neonatal and adult mice.
Exemplifying the useful symbiosis of animal experiments and computer modeling, the paper describes the quest to understand the interplay between genetic patterns and physiological traits that contribute to weight in mice.