Sentences with phrase «genetic association studies of»

The presence of 1 or 2 copies of the S variant influences predisposition to anxiety, avoidant behaviors, and interpersonal negative emotionality according to several, but not all, genetic association studies of adults, 20 while a recent study of childhood shyness - BI21 found an association in the opposite direction (ie, with the LL genotype).

We partner to provide genetic data combined with breed - specific health and research surveys, powering genetic association studies of the future.

For example, genetic association studies of psychiatric disorders have located gene variants associated with the disorders, but have been able to explain only a small percentage of their heritability.

Not exact matches

Meta - analyses of genome - wide association studies conducted in these ethnically - diverse populations identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.

The new framework enhances the ability to detect genetic associations and interactions by taking advantage of data from other genomic studies of the same population.

In the second study, Dr. McCoy and colleagues demonstrated the application of this new method to examine the association between symptom dimensions and common genetic variation in psychiatric disease.

A Mayo Clinic study has identified a familial association in spontaneous coronary artery dissection, a type of heart attack that most commonly affects younger women, suggesting a genetic predisposition to the condition, researchers say.

The Immunochip for fine - mapping is an important tool for conducting genome - wide association studies of the genetic components of disease.

The results show that distinct genetic profiles underlie specific memory processes: The study reports, for example, associations between a transporter protein set and the process of learning as well as between a cell adhesion set and the process of memory storage.

«Genetic association with aggressive prostate cancer discovered: Study showed a threefold increase in the risk of aggressive prostate cancer for men with the genetic mutation..Genetic association with aggressive prostate cancer discovered: Study showed a threefold increase in the risk of aggressive prostate cancer for men with the genetic mutation..genetic mutation..»

In their investigations or so - called genome - wide association studies, the team of researchers compared the genetic profile of study participants to the forced vital capacity (FVC), a volume parameter of lung function.

With a grant from the Morris Animal Foundation, Antczak, his collaborators Samantha Brooks and Ann Staiger from the University of Florida, and the rest of the team applied a genomewide association study to compare the genetic makeup of horses with and without sarcoid tumors at more than 50,000 sites in the equine genome.

African populations harbour the greatest genetic diversity and have the highest per capita health burden, yet they are rarely included in large genome studies of disease association.

Results of each statistical test should be reported in full with the value of the test statistic and p - value, and not simply reported as significant or non-significant; more than two significant digits on p - values are usually not needed except in situations of extreme multiple testing such as in genetic association studies where stringent corrections for multiple testing might be used.

The research team's hunt for such age - related genetic associations involved studying more than 8 million single nucleotide polymorphisms — changes of one nucleotide for another at a particular spot in the DNA — in 2,693 individuals.

In conducting their study, which includes detailed behavioral, medical and genetic observations of 14 boys with CS from 12 families, the team of scientists and physicians worked closely with families of the small but fast - growing Christianson Syndrome Association, including hosting the group's inaugural conference at Brown's Alpert Medical School last summer.

The association study matches genetic variants with a trait by looking at large groups of people with that trait and then compares how their genomes differ from a group without the trait.

So I clicked on it: «Because genetic association studies are generally performed in populations of a particular ethnic background [European, Asian, African], we can not know whether the associations will also apply to those of a mixed background.

Of these twelve genetic regions, six are also associated with IBD, while the six other regions showed little to no association in a recent large study of IBOf these twelve genetic regions, six are also associated with IBD, while the six other regions showed little to no association in a recent large study of IBof IBD.

«Our approach is likely to «revive» genome - wide association studies as a strategy to identify genetic risk factors and to develop novel treatment options for a wide range of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»

All of these studies were genome - wide association studies (GWAS) based on millions of genetic variants called Single Nucleotide Polymorphisms (SNPs).

Clinical features of major depressive disorder (MDD) may help identify specific subgroups of depressed patients based on associations with genetic risk for major psychiatric disorders, reports a study in Biological Psychiatry.

In 2013, a genome - wide association study of AD in more than 5,500 African Americans identified two genetic risk factors for AD.

Genome - wide association studies, which try to find correlations between particular genetic variations and disease diagnoses, are a staple of modern medical research.

Nestadt says the genome - wide association study findings of a PTRPD - OCD link add to evidence that the genetic region they identified is important.

«Now, using a genetic approach, researchers at the University of Leicester undertaking the study on behalf of an international consortium of scientists (the CADIoGRAM + C4D consortium) have shown that the association between shorter height and higher risk of coronary heart disease is a primary relationship and is not due to confounding factors.»

The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2016) showed for the first time an association between a specific genetic pathway and the development of mouth ulcers in patients with Systemic Lupus Erythematosus (SLE).

Professor Jeremy Pearson, Associate Medical Director at the BHF, which part - funded the study, said: «By using the power of very large scale genetic studies, this research is the first to show that the known association between increased height and a lower risk of coronary heart disease is at least in part due to genetics, rather than purely down to nutrition or lifestyle factors.

So Chakravarti and colleagues conducted a new genomewide association study of the disease, comparing the genetic markers of more than 650 people with Hirschsprung's disease, their parents and healthy controls.

The team also found the same pattern of results in an independent cohort of almost 1,500 people who were part of the Brisbane Longitudinal Twin Study, suggesting the genetic association in females is a reliable finding.

«Future studies on maternal smoking and other environmental, genetic, and epigenetic factors, as well as animal models, should allow identification of the biological mechanisms responsible for these associations.

«No link found between subcortical brain volumes, genetic risk for schizophrenia: Proof - of - concept study provides roadmap for future research into possible associations between brain volume measures, known genetic risk factors.»

These so - called genome - wide association studies have turned up hundreds of genetic markers linked to diseases such as cancer and diabetes.

To explore the genetic contribution, we undertook a genome - wide association study of exceptional longevity (EL) in 1055 centenarians and 1267 controls.

A recent human study also indicated a genetic association of the αCaMKII gene with bipolar disorder, and decreased expression of αCaMKII has been observed in postmortem brains of patients with bipolar disorder.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

The team selected possible leads from the intersection of more than 20,000 p53 binding sites in the human genome, 10 million inherited genetic variations genotyped in the 1000 Genomes Project, and 62,000 genetic variations associated with human cancers identified in genome - wide association studies (GWAS).

Scientists for years have looked for the biological roots of the problem using tools such as genome - wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.

The research team, following up on a previous genome - wide association study by researchers at Baylor College of Medicine, investigated genetic variations in a protein called FBN - 1, which is essential for a strong arterial wall.

The challenge of genetic association studies — especially ones for complex phenotypes — is confirming statistical evidence of association with a functional assay.

If this is true, then there are important implications for genetic association studies, which often rely on surveys of common genetic variation in the human genome.

«A genome - wide association study of positive emotion identifies a genetic variant and a role for microRNAs.»

For a study published in the journal Biological Psychiatry, Ole Andreassen and colleagues compared genetic information from Neanderthals and modern humans and found an association between markers of human evolution and genetic risk for schizophrenia.

In a recent study presenting genome - wide association metaanalysis, the genetic background of body fat accumulation and its relation with cardiometabolic traits was investigated (187).

Previous genome - wide association studies (GWAS) by the group have identified new genetic risk factors for the higher rates of asthma and poor response to bronchodilator medications seen in these minority populations — in many cases different from risk factors seen in prior studies conducted in European Americans.

«PrediXcan tells us which genes are more likely to affect a disease or trait by learning the relationship between genotype, gene expression levels from large - scale transcriptome studies, and disease associations from GWAS studies,» said study leader Hae Kyung Im, PhD, research associate (assistant professor) of genetic medicine at the University of Chicago.

We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution.

The study entitled «A multi-national Arab genome - wide association study identifies new genetic associations for Rheumatoid Arthritis», has now been published in the prestigious medical journal Arthritis & Rheumatology; and was supported by grant from the Qatar National Research Fund, a member of Qatar Foundation.

In 2013, an expert panel made up of members of the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology published guidelines describing the genetic tests that should be performed to evaluate a patient's lung cancer.

These super-cohorts will tell us a great deal about rare variation and may even provide the power for robust studies of genetic association.