«This reinforces the importance of rigorous
genetic background control when we are measuring complex traits,» says Scott Pletcher of the University of Michigan in Ann Arbor.
In contrast with the BN rat strain, the disruption of the Themis1 gene in LEW rats does not lead to the spontaneous development of IBD or functional Treg defect, suggesting that an epistasis phenomenon in the BN
genetic background controls these phenotypes.
Not exact matches
Each of these four transgenic lines was backcrossed at least 6 times to C57 BL / 6 mice prior to analysis in order to
control for
genetic background effects.
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Genetic quality control monitoring Whole genome scanning (rapid or more detailed) for routine strain background monitoring, or in case of suspected contamination error, is a quick, inexpensive and reliable method compared to physical, immunological and biochemical assays, traditionally used for genetic quality asse
Genetic quality
control monitoring Whole genome scanning (rapid or more detailed) for routine strain
background monitoring, or in case of suspected contamination error, is a quick, inexpensive and reliable method compared to physical, immunological and biochemical assays, traditionally used for
genetic quality asse
genetic quality assessment.
Still, because they carry random combinations of alleles from the C57BL / 6 and 129
genetic backgrounds, they are more appropriate
controls than are mice of either parental strain.
F2 hybrids may be used as physiological
controls for targeted mutants (knockouts) with a mixed C57BL / 6 x 129
genetic background (designated B6; 129).
For confirmation, we exploited the flexibility of our system, enabling tamoxifen inducible conditional gene ablation while
controlling for
genetic background and tamoxifen effects.
The striking differences observed in Themis1 - deficient rats of the BN and LEW
genetic backgrounds suggest that an epistasis between Themis1 and other gene (s)
controls Treg function.
Background The ASPCA recognizes that there are dogs who by virtue either of training or lack of training and socialization — especially in combination with a
genetic predisposition to be wary of strangers, aggressive toward other dogs and / or predatory toward other animals — may pose serious threats if inadequately supervised and
controlled by their guardians.
Using a method that tests specific
genetic effects while
controlling for
background genetic effects, we estimate covariation between children's
genetic liability / propensity for core developmental outcomes and a wide range of environmental exposures.