Sentences with phrase «genetic background controls»

In contrast with the BN rat strain, the disruption of the Themis1 gene in LEW rats does not lead to the spontaneous development of IBD or functional Treg defect, suggesting that an epistasis phenomenon in the BN genetic background controls these phenotypes.

«This reinforces the importance of rigorous genetic background control when we are measuring complex traits,» says Scott Pletcher of the University of Michigan in Ann Arbor.

Not exact matches

Each of these four transgenic lines was backcrossed at least 6 times to C57 BL / 6 mice prior to analysis in order to control for genetic background effects.

• Genetic quality control monitoring Whole genome scanning (rapid or more detailed) for routine strain background monitoring, or in case of suspected contamination error, is a quick, inexpensive and reliable method compared to physical, immunological and biochemical assays, traditionally used for genetic quality asseGenetic quality control monitoring Whole genome scanning (rapid or more detailed) for routine strain background monitoring, or in case of suspected contamination error, is a quick, inexpensive and reliable method compared to physical, immunological and biochemical assays, traditionally used for genetic quality assegenetic quality assessment.

Still, because they carry random combinations of alleles from the C57BL / 6 and 129 genetic backgrounds, they are more appropriate controls than are mice of either parental strain.

F2 hybrids may be used as physiological controls for targeted mutants (knockouts) with a mixed C57BL / 6 x 129 genetic background (designated B6; 129).

For confirmation, we exploited the flexibility of our system, enabling tamoxifen inducible conditional gene ablation while controlling for genetic background and tamoxifen effects.

The striking differences observed in Themis1 - deficient rats of the BN and LEW genetic backgrounds suggest that an epistasis between Themis1 and other gene (s) controls Treg function.

Background The ASPCA recognizes that there are dogs who by virtue either of training or lack of training and socialization — especially in combination with a genetic predisposition to be wary of strangers, aggressive toward other dogs and / or predatory toward other animals — may pose serious threats if inadequately supervised and controlled by their guardians.

Using a method that tests specific genetic effects while controlling for background genetic effects, we estimate covariation between children's genetic liability / propensity for core developmental outcomes and a wide range of environmental exposures.