Sentences with phrase «genetic basis of brain»

This study demonstrates that regional correlations between CT and CSA asymmetries are a characteristic of brain structural organization that could be of significance in the choice of structural markers in studies dealing with the genetic basis of brain lateralization.

Not exact matches

A team led by geneticist Steven McCarroll of the Broad Institute, based in Cambridge, Mass., combed through genetic information from about 29,000 schizophrenia cases, 36,000 controls and 700 brain samples from deceased patients.

«What we found is a piece of the genetic basis for why we have a bigger brain,» Wray said.

Breast cancers that metastasize to the brain are usually deadly, but a team based at the University of Mississippi Medical Center has discovered a possible fix: a tiny fragment of genetic material known as microRNA.

In 1993, Poirier and his Montreal - based team co-discovered an important genetic risk factor involved in the most common form of the disease: a defective gene, called Apolipoprotein E type 4 (ApoE4), that prevents the normal transport of cholesterol and phospholipids to the brain.

Now, to enable widespread gene delivery throughout the central and peripheral nervous systems, Caltech researchers have developed two new variants of a vector based on an adeno - associated virus (AAV): one that can efficiently ferry genetic cargo past the blood - brain barrier; and another that is efficiently picked up by peripheral neurons residing outside the brain and spinal cord, such as those that sense pain and regulate heart rate, respiration, and digestion.

Particularly interesting was the discovery that the thickness of the gray matter in the brain's temporal and prefrontal regions — the structures that are critical for language and for higher - order cognitive functions like self - control and problem - solving — were the most promising candidate traits for genetic mapping, based on both their strong genetic basis and association with the disease.

«Although the genetic basis of the disease is well established, why the mutation leads to the expression of symptoms and loss of brain tissue remains poorly understood,» explained senior author Mark Bevan, professor of physiology at Northwestern University Feinberg School of Medicine.

Dogs exhibit the same behavioral characteristics, respond to the same medication, have a genetic basis to the disorder, and we now know have the same structural brain abnormalities as people with OCD,» said Nicholas Dodman, BVMS, DACVB, professor of clinical sciences at the Cummings School of Veterinary Medicine at Tufts University.

Our study, along with prior studies, supports the notion that «cognitive reserve» resulting from early - life and lifelong education and cognitive stimulation may be a potent strategy for the primary prevention of dementia in both high - and low - income countries around the world.21 However, it should be noted that the relationships among education, brain biology, and cognitive function are complex and likely multidirectional; for instance, a number of recent population - based studies have shown genetic links with level of educational attainment, 22,23 and with the risk for cognitive decline in later life.24 Higher levels of educational attainment are also associated with health behaviors (eg, physical activity, diet, and smoking), more cognitively - complex occupations, and better access to health care, all of which may play a role in decreasing lifetime dementia risk.

A technique based on genetic bar codes can easily map the connections of individual brain cells in unprecedented numbers.

«Brain study reveals insights into genetic basis of autism.»

More recently, I have demonstrated the feasibility of using fMRI in combination with pharmaco - genetic silencing to dissect the circuital basis of complex behaviors, and demonstrated for the first time that the mouse brain contains distributed resting - state functional connectivity networks, including plausible homologues of the human default - mode (DMN) and salience networks.

The booklet provides an overview of the symptoms, risk factors, genetic basis and impact on the Arab World of five common neurological brain disorders, namely Alzheimer Disease, ADHD, Intellectual Disability, Schizophrenia and Tourette syndrome.

His research is based on the concept that normal brain aging and the pathogeneses of sporadic neurological diseases are not a consequence of a few single or «disease - specific «factors alone, rather they are driven by holistic events that include one's individual genetic and epigenetic condition, progression of aging, and lifestyle.

But the question of what percentage of the brain's structure and function is based on genetic predisposition or on experience doesn't have a clear - cut answer.

In addition to hinting at a link between depression and brain gene expression during development, there was also evidence of overlap between the genetic basis of depression and other mental illnesses.

More recently, his lab started studying the genetic basis of human brain evolution as well as the signaling pathways underlying synaptic loss during early stages of Alzheimer's Disease progression.

The society has members world wide that study the genetic basis of a wide range of behaviors and brain disorders together with the underlying neuronal mechanisms using diverse species.

Our groundbreaking Pediatric Mi - Oncoseq Program is an internationally known precision oncology program focusing on the genetic analysis of pediatric cancer patients including in children with malignant brain tumors, and determines whether targeted treatments may be available based upon their personalized tumor genomic sequencing profiles.

Dr. Hardy posits that, based on archaeologic, anthropologic, genetic, and physiologic data, it was actually the coevolution of cultural use of fire, cooked starch, and salivary / pancreatic amylase that afforded the brain the capacity for a quantum leap in evolution.

The reason for these «defects» stems from genetic defect s in the hypophysis or pituitary gland, the «master gland» deep in the base of the brain.

Characterization of genetic mutations, genetic testing and development of gene - based therapies for muscular dystrophies and inherited metabolic brain diseases similar to Tay - Sachs disease.

There was, however, a significant question as to his mental capacity based on the fact that the client was a victim of Huntington's Disease, noted by the court as «a genetic brain disorder that results in the progressive loss of both cognitive functions and physical control.»