Sentences with phrase «genetic data in the study»

As the genetic data in the study comprise the deepest divergence among now living humans, the researchers developed a novel method to examine what genetic changes were underway when modern humans emerged more than 100 000 years ago.

Not exact matches

In contrast, the new study made use of wrist accelerometer data, which is more objective and quantifiable, and a large genetic dataset from about 85,000 UK Biobank participants aged 40 to 70.

In their study, the researchers analyzed genetic data from around 11,000 men with premature baldness.

Goebel is also co-author of a 2015 study published in Science that brings together genetic and archaeological data to end speculation.

Combing the genetic data from a transmission study in ferrets, a team led by Thomas Friedrich, a professor of pathobiological sciences at the University of Wisconsin - Madison School of Veterinary Medicine, found that during transmission, when one animal is infected by another through sneezing or coughing, the process of natural selection acts strongly on hemagglutinin, the structure the virus uses to attach to and infect host cells.

Collaborators in Australia and Chile provided DNA for the study, and W. Mark Whitten and Norris Williams of the University of Florida provided genetic data.

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cookinIn a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cookinin The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cookinin the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

They studied genetic data from 1,983 living individuals across Africa, Europe, Asia, Oceania, and the Americas and concluded that Neanderthals or another ancient hominid group must have interbred with our ancestors at least once, in the eastern Mediterranean, soon after humans migrated out of Africa.

The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of schizophrenia and also found that some of the genes identified as increasing risk for schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability and autism spectrum disorders.

Some scientists studying the genetic makeup of the West African Ebola strain were slow to share their data with others, perhaps fearful that they would lose their right to publish their findings in a major scientific journal.

Mayer and McHugh also appear to be data snooping when they reference only one of six studies in the peer - reviewed literature of the past 16 years that employ proper probability - sampling methods, «and it just so happens to be the one with the lowest estimate of genetic influence of the entire set,» Hamer says.

«I think this is a step towards making sense out of a lot of data — genetic data, environmental data, epidemiological data — to help us understand factors that contribute to long and healthy life,» says Winifred Rossi, deputy director of the Division of Geriatrics and Clinical Gerontology at the National Institute on Aging, who wasn't involved in the study.

HUR K Junho, first author of the study said, «The data showed that Cpf1 RNP's delivery to mouse embryos resulted in knocking out the intended genetic functions with high mutation frequencies, 64 % and 33 % respectively.

Ávila - Arcos hopes to use genetic data to trace the ancestors of those in her study back to specific West African groups or regions.

In all, the study included the data of more than 23,000 people to show that approximately 12 percent of a person's variation in delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traitIn all, the study included the data of more than 23,000 people to show that approximately 12 percent of a person's variation in delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traitin delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traits.

In this study, a team led by Panos N. Papapanou, DDS, PhD, professor and chair of oral, diagnostic and rehabilitation sciences at the College of Dental Medicine at CUMC, «reverse - engineered» the gene expression data to build a map of the genetic interactions that lead to periodontitis and identify individual genes that appear to have the most influence on the disease.

A new study in the journal Genetics in Medicine, published by Springer Nature, now shows that up to 40 percent of direct - to - consumer (DTC) genetic tests provide incorrect readings in the raw data.

Much of the data in the study has come out previously, some in earlier papers about the parents of the virus that «reassorted» to make this new H1N1, some in the flood of genetic sequences put into public databases, and some in press interviews with public health agencies and academic investigators.

However, the study's Canaanite genetic data do provide «a snapshot of history in the area,» Lazaridis says.

The genetic data, combined with updated morphological study of some of the oldest ancient canid remains, could strengthen the dual origin theory proposed in June — or it could build a case for even more origin events.

In the new work, researchers looked at genetic and health data on more than 100,000 individuals from previous large studies to determine whether genetic alterations that are associated with vitamin D levels predispose people to asthma, dermatitis, or high IgE levels.

In an accompanying editorial, Emad M. El - Omar, M.D., of Aberdeen University, Aberdeen, United Kingdom, writes that the authors of this study are appropriate to state, «based on their data, genetic testing to evaluate H pylori susceptibility is premature.»

Now, a new study that included genetic data from more than 190,000 people has identified two genes that, when altered in specific ways, either promote or undermine cardiovascular health.

His adviser at the time, animal genomicist Martien Groenen of Wageningen University and Research Centre in the Netherlands, had sequenced these genomes and had gathered additional, albeit less complete, genetic data from 600 other wild and domesticated pigs as part of another study.

In the new study, they used the same genome - wide information and the largest data sets currently available to estimate the risk for the illnesses attributable to any of hundreds of thousands of sites of common variability in the genetic code across chromosomeIn the new study, they used the same genome - wide information and the largest data sets currently available to estimate the risk for the illnesses attributable to any of hundreds of thousands of sites of common variability in the genetic code across chromosomein the genetic code across chromosomes.

An international team of scientists, led by researchers from the University of Tuebingen and the Max Planck Institute for the Science of Human History in Jena, successfully recovered and analyzed ancient DNA from Egyptian mummies dating from approximately 1400 BCE to 400 CE, including the first genome - wide nuclear data from three individuals, establishing ancient Egyptian mummies as a reliable source for genetic material to study the ancient past.

For the study, an international team of researchers based at institutions in Spain, the United States, Canada and Australia used mitochondrial DNA and microsatellite genotypic data to investigate the levels of genetic variation and to reconstruct the history of the invasions.

«The critical next step is to study this biological mechanism in a mammalian model and generate data to support a clinical trial of rapamycin or a related drug for DCM patients who have these genetic variants.»

The researchers said the work demonstrates that, in fact, multi-tissue, multi-individual data can be used to identify the mechanisms of gene regulation and help to study the genetic basis of complex diseases.

In order to investigate whether a healthy lifestyle can mitigate genetic risk, the multi-institutional research team analyzed genetic and clinical data from more than 55,000 participants in four large - scale studieIn order to investigate whether a healthy lifestyle can mitigate genetic risk, the multi-institutional research team analyzed genetic and clinical data from more than 55,000 participants in four large - scale studiein four large - scale studies.

Studies of the modern species» blood - feeding physiology got a solid source of new data in 2013 when an international team decoded the genetic instruction book of the sea lamprey, a notorious invader of the Great Lakes.

«With disparate time estimates coming from the genetic studies, we need archaeological data to fix the chronology for when people are present in different places,» Rademaker says.

A final study, led by University of California, San Francisco, Washington University in St Louis and Yale School of Medicine, USA, analyzed genetic data from over 4,500 families affected by autism.

Persuading large numbers of people from minority groups that have been ignored or even mistreated historically in biomedical studies to share their medical records and genetic data with researchers may be a tall order.

In separate efforts, each team pooled genetic and height data collected from other studies to amass information on 13,000 to 31,000 people.

A team led by Corinne Simonti at Vanderbilt University in Nashville, Tennessee, studied medical records and genetic data from more than 28,000 people of European descent.

Dr Louise Wain, Associate Professor in Genetic Epidemiology who led the team of analysts at the University of Leicester added: «The research shows the value of the UK Biobank study and of «big data» for making discoveries that will improve health.

But the technique also creates a privacy concern about health data; the National Institutes of Health (NIH) in Bethesda, Maryland, is now backpedaling on a policy mandating genetic sharing developed just 8 months ago for fear that the health information of people who participated in the studies could be identified.

A second part of the study, a comparison of genetic data of the mummy with data from other European Neolithic samples, provided information regarding the origin of K1f: researchers postulate that the mitochondrial lineage of the Iceman originated locally in the Alps, in a population that did not grow demographically.

«We can see the huge genetic impact that the slave trade had on American populations and our data match historical records», said study author Dr Garrett Hellenthal from the UCL Genetics Institute, «The majority of African Americans have ancestry similar to the Yoruba people in West Africa, confirming that most African slaves came from this region.

Putting together the genetic data on the ancient and modern samples, namely those already present in the literature and those analysed in this study, researchers have now proposed the following scenario to explain the Iceman's genetic history: Ötzi's paternal lineage, G2a, is part of an ancient genetic substrate that arrived in Europe from the Near East with the migrations of the first Neolithic peoples some 8,000 years ago.

Kohn, who tracks the genetic roots of mice to see how favorable evolutionary traits develop, and Nakhleh, who studies evolution by comparing genomic data, shared their findings this week in the Proceedings of the National Academy of Sciences.

Previous studies have reported an increase in fatigue resistance in EDL muscles following genetic manipulation of Actn3 (40) and Pgc - 1α (41), although differing fatigue protocols preclude direct comparison with the current data in the IL - 15Rα — KO mouse.

Scientists for years have looked for the biological roots of the problem using tools such as genome - wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.

In addition to genetic data and microbiome composition, the information collected for each study participant included dietary habits, lifestyle, medications and additional measurements.

Of the 22 patients whose tumors successfully grafted, six died before data from the mice were available, but in 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsIn a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin cases where genetic sequencing of the tumor showed no actionable mutations.3

In the case of clinical next - generation sequencing, and in genetic cohort studies and biobanks, pertinent issues include the interpretation of data, data storage, data sharing, informed consent and identifiability / privacy [20][26In the case of clinical next - generation sequencing, and in genetic cohort studies and biobanks, pertinent issues include the interpretation of data, data storage, data sharing, informed consent and identifiability / privacy [20][26in genetic cohort studies and biobanks, pertinent issues include the interpretation of data, data storage, data sharing, informed consent and identifiability / privacy [20][26].

To address IBD, Jansson's team has collaborated with bioinformaticians to integrate overwhelming amounts of new genetic data, and has published studies comparing healthy microbiomes to those in IBD patients - all with the aim of future diagnostics and potential new therapies, she said.

In this pilot study, we present an automated bioinformatics approach for the integration of WES with UM data from seven neurometabolic patients with known IEMs and 15 controls; our goal was to identify concordance between genetic and metabolomic dysregulation and illustrate the challenges and successes of combining such large datasets.

In these studies, sequence data from several thousands of individuals is compared to find disease - associated genes where cases have a higher load of genetic variants that are likely to disturb gene function, compared to the controls.