Not exact matches
«Our findings show that population
differences in transcriptional
responses to immune activation are widespread, and that they are mainly accounted for by
genetic variants that differ
in their frequencies between human populations,» said Lluis Quintana - Murci of Institut Pasteur and CNRS
in Paris, France, who led one of the two studies.
This visual abstract depicts how
genetic variants enriched
in population specific signals of natural selection and, among Europeans, of Neandertal ancestry play a major role
in the
differences in transcriptional
responses to inflammatory and infectious challenges observed between human populations.
«These results provide a first description of
differences in immune
response and associated
genetic basis that might explain
differences in susceptibility to disease between people of African and European ancestry.
Boyle's group has shown, for instance, that
genetic differences influence the effectiveness of a modified Brucella
in eliciting a protective immune
response in cattle.
The authors wrote: «We argue that
in the era of precision medicine, potential
differences in response to compounds that disrupt the cholesterol biosynthesis pathway must be respected, especially as their effect may be defined by both
genetic makeup and life events at the same time.»
I remember Dr. Rosedale speaking of how there are
genetic differences in how much insulin is released
in response to carbs and that the people who have higher insulin
responses to meals are prone to developing hyperinsulinemia over time.
Of course, it gets even more complicated than that, because variations
in genetics means that some metabolic types tolerate fats well and some do not, so diet tests administered without regard for
genetic differences will produce conflicting results, and the complication then gets even deeper
in that hunger may be a generic
response to nutritional deficiencies.