Sentences with phrase «genetic drivers of»

Here we present a rapid genome - wide approach capable of identifying multiple genetic drivers of medically relevant phenotypes within malaria parasites via a single experiment at single gene or allele resolution.

In the last decade the identification of genetic drivers of melanoma cell which regulate proliferation and survival - such as BRAF and other activators of the MAP - kinase pathway - along with the recent development of immunotherapy has taken away in many cases the invasive treatment of melanoma as an option.

These therapies were born out of a deep understanding of the potent genetic drivers of lung cancer, particularly in nonsmokers.

Genomics provides the ability to identify and target genetic drivers of disease.

Not exact matches

«There are some people with a genetic predisposition to getting cancer — they tend to be relatively rare — but once you have a cancer, the major drivers of the behaviour of that cancer are genetic.

Earlier detection of brain metastases could increase the chances of successful surgical removal of the tumors, says Sanford Simon, whose Laboratory of Cellular Biophysics previously identified the genetic driver behind fibrolamellar.

«Intensive DNA sequencing efforts to find the genetic «drivers» of metastasis, which is what kills patients in up to 80 percent of cases, have thus far been disappointing, to say the least,» he said.

Research into the drivers of genetic diversity has largely focused on gene expression, which controls how much of a given protein will be made, when, and in what tissue.

Evolutionary biologists and animal behavior researchers are searching out the genetic basis and molecular drivers of cooperative behaviors, as well as the physiological, environmental, and behavioral impetus for sociality.

Cells with weak driver mutations needed other background mutations to grow well in antimicrobial drugs, however cells with strong driver mutations developed resistance to drugs regardless of the genetic background.

If metastatic cancers are most often made up of cells with different genetic drivers, perhaps researchers should be targeting the primary tumor with multiple drugs to contain the cancer.

The new finding is the latest evidence supporting a growing precision medicine model of psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple psychiatric disorders, with other genetic or epigenetic drivers, random developmental events, or environmental influences determining the specific disease an individual develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.

Elderly fathers pass along many more DNA errors than do young ones — a source of genetic diversity, but also a possible driver of autism and other disorders.

An implicit assumption in the discipline of speciation biology is that genetic differences between populations of animals and plants in a given species are important drivers of new species formation and are a key to understanding evolution.

The composition of the diet and the degree of physical activity are the main drivers determining the risk to develop non-alcoholic fatty liver disease in addition to genetic predisposition.

Will genetic engineering and biotechnical or nanotechnological manipulations become the new drivers of human evolution?

Drivers that have been associated with these declines include, but are not limited to, socioeconomic concerns (e.g. agricultural intensification), invasive pests and / or pathogens (e.g. Varroa, Nosema), agrochemicals (e.g. neonicotinoids) and a decline in genetic diversity of bee populations and food sources (e.g. over-reliance on one floral source)[11 — 17].

The linear subtype is propelled by just two driver events: a genetic condition called von Hippel - Lindau syndrome, and loss of one copy of an allele in chromosome 3.

Using induced pluripotent stem cells (iPSCs), a team led by Mount Sinai researchers has gained new insight into genetic changes that may turn a well known anti-cancer signaling gene into a driver of risk for bone cancers, where the survival rate has not improved in 40 years despite treatment advances.

As the first step in a next generation knowledge system for cancer, the GDC enables and accelerates efforts to identify both high - and low - frequency cancer driver mutations, assists in revealing the genetic determinants of response to therapy, and informs the composition of clinical trial cohorts.

This suggests that living together is a key driver of similarity within families for anxiety, even after accounting for genetic similarities.

Using genetic and epigenetic analyses coupled with powerful perturbation technologies to test gene functions in human cells and mouse models, we hope to identify the critical drivers of this disease and the basis for therapeutic responses.

First Major Gene Mutation for Hereditary Prostate Cancer Found After a 20 - year quest to find a genetic driver for prostate cancer that strikes men at younger ages and runs in families, researchers have identified a rare, inherited mutation linked to a significantly higher risk of the disease.

Classic selective sweeps, when a beneficial genetic mutation quickly spreads through the human population, are thought to have been the primary driver of human evolution.

The reversal suggests that smaller changes in multiple genes may have been the primary driver of changes in human phenotypes, and that new models are needed to retrace the genetic steps of evolution.

Genetic rescue via GAL4 / UAS - DTH was also successful, although this required the generation of a new UAS - DTH1 transgene devoid of most untranslated regions, since existing UAS - DTH transgenes express in the brain without a Gal4 driver via endogenous regulatory elements.

This policy document highlights that climate change will be an important driver of genetic erosion in the future.

That is why they have put the business up for sale, so they can «focus on the company's key profit drivers of agricultural seeds and development of specific genetic traits for crops.»