Sentences with phrase «genetic etiology of»

To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome - wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD.

Results indicate a common genetic etiology of psoriasis and obesity.

This study highlights the shared genetic etiology of many canine and human genetic disorders, and provides new tools to investigate PRA mechanisms while the beloved dogs benefit from genetic testing.

Not exact matches

It has been estimated that 5 % to 10 % of infants who die from SIDS have novel mutations in the cardiac sodium or potassium channel genes that result in long QT syndrome as well as in other genes that regulate channel function.44 A recent report described important new molecular and functional evidence that implicates specific SCN5A (sodium channel gene) β subunits in SIDS pathogenesis.47 The identification of polymorphisms in genes pertinent to the embryologic origin of the autonomic nervous system in SIDS cases also lends support to the hypothesis that a genetic predisposition contributes to the etiology of SIDS.

The new study quadruples the number of known genetic risk factors for Fuchs dystrophy, and helps explain its genetic etiology.

We are currently focusing our efforts on an exceptional resource of laboratory mouse strains with proven Mendelian disorders with unknown genetic etiology, strains stewarded by the Mouse Mutant Resource at The Jackson Laboratory for over 50 years.

Dr. Torkamani's research covers a broad range of areas centered on the use of genomic technologies to identify the genetic etiology and underlying mechanisms of human disease in order to define precision therapies for diseased individuals.

Until now the following parameters have been identified with the etiology of colorectal cancer genetic mutations, inflammatory processes, diet, and the gut microbes.

As an example, skeletal malformations and dysplasias, often detected through routine prenatal ultrasound examination, constitute a phenotypic finding in more than 300 syndromic and non-syndromic disorders and their genetic etiology may be due to a wide variety of genetic aberrations, ranging from copy number variations to single gene mutations.

In the current work, researchers led by John B. Harley, M.D., Ph.D., director of the Center for Autoimmune Genomics and Etiology (CAGE) at Cincinnati Children's Hospital Medical Center, with his colleagues Matthew T. Weirauch, Ph.D., and Leah C. Kottyan, Ph.D., also of CAGE, wondered whether genetic analysis could further explain the relationship between EBV infection and lupus.

Dr. Mullegama: My research focuses on understanding the genetic etiology and phenotype of rare neurodevelopmental genetic disorders.

It is classified as a distinct primary cardiomyopathy with a genetic etiology and may be an isolated finding or may also be associated with other forms of structural congenital heart disease (Jenni et al., 2001).

Previous studies suggest that genetic and environmental factors play a role in the etiology of ASD.1 - 3

176/6: 15 The genetics of emphysema: Mutations in telomere genes uncover a distinct genetic etiology and common mechanism for pathogenesis.

Although both scientists and lay people alike may frequently identify a single dietary element as the cause of chronic disease (eg, saturated fat causes heart disease and salt causes high blood pressure), evidence gleaned over the past 3 decades now indicates that virtually all so - called diseases of civilization have multifactorial dietary elements that underlie their etiology, along with other environmental agents and genetic susceptibility.

Perhaps for this reason, the etiology of ASD is not well defined and the combinations of environmental and genetic factors that protect against or increase risk of developing autism are not well understood.

Numerous twin studies have examined the genetic and environmental etiology of reading comprehension, though it is likely that etiological estimates are influenced by unidentified sample conditions

Type 2 diabetes has a complex etiology and is caused by a combination of genetic factors and environmental interactions, and risk increases with aging (11,12).

Etiology of this tumor is largely unknown; genetic, physiologic, and molecular influences have all been implemented in possible causative factors1.

Our pedigree analysis included Swedish vallhund dogs examined in seven different countries, spanning three continents, and was highly suggestive of a genetic etiology and an autosomal recessive mode of inheritance.

Altogether our results add more evidence for shared etiology and mechanisms of OCD in dogs and humans [6], and suggest that both environmental and genetic factors affect compulsive behaviour.

This is most likely because diseases like CM and syringomyelia have a complex etiology and disease expression probably occurs when there is a threshold combination of genetic and environmental factors.

Although an independent replication of this genetic finding is required, it provides further support that overlapping etiologies may lead to compulsive behaviours across species.

We investigated the temporal pattern of genetic and environmental etiology of PA during this crucial developmental period.

Together with evidence that GAD and depression co-occur more often with one another than with other disorders20, 57 and have shared genetic etiology, 58,59 this lends support to the notion of grouping these disorders more closely than is currently reflected in the DSM - IV.

Genetic and Environmental Etiology of the Relationship Between Childhood Hyperactivity / Inattention and Conduct Problems in a South Korean Twin Sample.

However, the precise genetic polymorphisms implicated in the etiology of antisocial behaviors remain elusive.

Genetic factors in the etiology of criminal behavior.

Opportunities to refine phenotypes through an understanding of their genetic influences will be important to characterize genetic and environmental etiologies.

The etiology of conduct disorder involves an interaction of genetic / constitutional, familial and social factors.

A longitudinal behavioral genetic analysis of the etiology of aggressive and nonaggressive antisocial behavior

Molecular genetic findings support the thesis that dopaminergic, serotonergic, and noradrenergic neurotransmission pathways account for the etiology of this complex disease.

The genetic - environmental etiology of parents» perceptions and self - assessed behaviours towards their 5 - month - old infants in a large twin and singleton sample

Our goals were (1) to compare the trajectory of depressive symptoms among boys and girls from childhood into adolescence; (2) to analyze the role of genetic, shared, and unique environmental factors in depression among prepubertal and pubertal male and female twins; and (3) to investigate a possible common etiology between liability to depression and one salient index of the child's environment: past - year life events.

Considering the complexity of mental illnesses etiology, which involves multiple interacting genetic, environmental and biological factors; large effect sizes are unlikely to be detected; therefore the magnitude of the associations described in this community - based study are noteworthy and possibly indicative of clinical relevance.