Sentences with phrase «genetic knockout mice»

They used genetic knockout mice to look for the cells, silencing different types of TRCs, then flushing the rodents» mouths with water to see which cells responded.

Not exact matches

Wherry and his collaborators used PD - 1 knockout mice infected with lymphocytic choriomeningitis virus to see whether the genetic deletion of PD - 1 would be enough to prevent T cell exhaustion.

These genetic modification techniques debuted in the 1980s, but the first autism knockout mice took a while longer to develop, emerging only in the early 2000s.

Zeroing in on this kinase was encouraging, Goga said, because other researchers have shown that genetic - knockout mice that lack the entire family of PIM kinases are slightly smaller than normal mice, but «basically fine,» indicating that a drug targeting just PIM1 may have manageable levels of toxicity in breast cancer patients.

Similarly, mice with a genetic knockout of the mouse equivalent of SELENBP1 had low levels of the protein and high levels of methanethiol and other volatile sulfur compounds in their blood.

The scientific community uses knockout mice to analyze basal phenotypes (the appearance of genetic characteristics) to analyze the function of such a large number of genes.

I haven't changed my genetic makeup when I exercise,» says Mario Capecchi, co-chair of the Department of Human Genetics at the University of Utah School of Medicine and a pioneer in working with knockout mice.

Instead of using the traditional method of introducing genetic mutations into mice to create «knockout» mice — or animals with customized genes — they found they were able to find naturally occurring variants among animals in the wild.

It is now possible to introduce mice strains (known as «knockout mice») in which specific genetic modifications can be activitated at specific times, or in specific cells or organs.

We also conduct electrophysiological, biochemical, imaging, antd behavioral studies with various knockout and transgenic mice to determine how precise genetic manipulations that either activate or abolish specific translational control mechanisms alter synaptic function and behavior.

This is disappointing with the vast array of genetic approaches available in mice; knockout rats, while limited in number so far, may prove useful.