Sentences with phrase «genetic lines used»

Talk to your Schnauzer Terrier Mix breeder about the health histories of both the Schnauzer and Terrier genetic lines used in your dog.

Not exact matches

Along this same line, the Wall Street Journal has an interesting article about the increasing use of blood tests shortly after birth to detect genetic diseases.

Where is the clear line in a progression from (1) using animal insulin to treat diabetes, to (2) using gene remodeling techniques to grow insulin in a host bacterium that will reproduce rapidly and from which a plentiful supply of insulin can be harvested, to (3) genetic surgery to replace the defective gene in a person diagnosed as diabetic, to (4) genetic surgery immediately after fertilization in order to replace the defective gene and alter the germ cells which would otherwise have transmitted the disease to one's offspring?

The researchers used two genetic lines of mice in the study to focus on AHR.

«We used different lines of evidence to show that ANGPTL3 deficiency is associated with a reduced risk of coronary artery disease,» said study co-author Kiran Musunuru, MD, PhD, MPH, an associate professor of Cardiovascular Medicine at Penn. «But ultimately we were able to identify that fact that carriers of this genetic mutation did in fact experience a benefit — with little other health risk.»

The intestinal lining chip can be used for the testing of treatments for inflammatory gastrointestinal diseases with a genetic component, such as Crohn's disease, ulcerative colitis and irritable bowel syndrome.

Using both fruit fly and human lung cancer cell lines, researchers targeted two of the most common genetic mutations associated with NSCLC — Ras and PTEN (P13K).

This will allow for informed decisions to be made with regard to the use of genetic lines derived from micropropagation when it comes to repopulating and conserving the plants.

If it's to be used at all, then it's important for scientists in their published research to be very clear about if it was used and to state the genetic lines of worms and experimental conditions of the research.

Now a team of British and American researchers has used genetic engineering to equip these biological production lines with the sets of tools they need to produce a range of tailor - made compounds.

For those surviving only in captivity, continued existence may depend on using banked cell lines to introduce some long - lost and much - needed genetic diversity into the mix.

Using genetic analyses, the researchers showed that a commonly used cell line which was established in Uppsala, Sweden, almost fifty years ago does not originate from the patient it is claimed to stem from.

A University of Colorado Cancer Center study published in the journal Oncogene used next - generation sequencing technologies to perform the most detailed DNA - based analysis to date of 25 commonly used bladder cancer cell lines, allowing researchers to match patient tumors with their closest genetic cell line match, and demonstrated genetic alterations that may make cells more or less sensitive to common therapies.

The study used whole - exome sequencing to characterize genetic alterations that occur at the single nucleotide level for all genes in 25 cell lines commonly used as models of bladder cancer.

By May 2005 they had used cloning techniques to create 11 stem cell lines, each one the perfect genetic match of a different patient, another first.

Germ - line genetic engineering clearly has dangers, not least its potential to be used for the wrong purposes or the potential for its cost to restrict its advantages to the wealthy.

It could be just decades before it is safe to attempt germ - line genetic engineering using recombinant DNA technology.

Then, the team used genetic analysis to look at mitochondrial DNA, which can pass only along the maternal line.

To see if any of these lay in genetic sequences on which the p53 protein acts, the investigators used data from several lines of healthy and cancerous cells subjected to various p53 - activating treatments.

On 11 March, the European Molecular Biology Laboratory (EMBL) issued a press release proudly announcing that a research team there had deciphered much of the genetic sequence of one of the most widely used cell lines in cancer studies and had made the information available publicly.

A study published in JAMA Pediatrics supports the use of genetic testing, especially with sequencing, as first - line diagnostic method for young children with seizures.

Data from these three lines of evidence were used to assess the antiquity and genetic stability of Chirikof's ground squirrel population and to reconsider the role of long - term data in the determination of native and indigenous species.

Using genetic techniques to knock out PBK slowed the growth of the group's adrenal cancer cell lines.

This is to increase the genetic potential of and genetic diversity among the male - sterile lines to be used in future recurrent selection (RS).

Earlier this year the team announced that they had cataloged 769 strong genetic dependencies across 501 CCLE - curated cell lines using genome - scale RNAi screens — the fruits of a nearly 10 - year effort.

• ES cell line purity verification In addition to mouse strain purity verification, the facility provides genetic screening of ES cell lines used for gene targeting experiments.

Using pre-implantation genetic diagnosis derived human embryonic stem cell lines (hES) or human induced pluripotent stem cells carrying the causal mutation for neuro - muscular diseases, our objective is double: identify new physiopathogical mechanisms and develop new therapeutic strategies.

In addition to our computational work, we run a small wetlab where we use CRISPR - Cas genome editing in human cell lines to obtain a deeper understanding of how genetic variants affect the cell.

«Especially in older individuals, but probably in all individuals, a good practice would be to... screen your iPSCs beforehand using a genomic or genetic approach so that you can screen out lines that might have a pathogenic variant,» Torkamani said.

hPSCreg provides comprehensive information on existing hPSC lines, their ethical procurement, derivation process, genetic and expression data and other molecular or biological characteristics, use and quality of the line.

The researchers used a modified virus to insert genetic mutations into cells lining the mice's lungs, causing the animals to develop tumors.

The technical evaluation of projects may require the provision of additional data such as information on the genetic modification of your mutant mouse line if applicable (e.g. affected gene, MGI ID of the gene, type of mutation, ES - cell line used, genetic background (e.g. number of backcross generations), safety level, description of DNA modification, vector, remaining non-recipient DNA, donor organism), mutant phenotype (s), special housing or care requirements, current sanitary status, and intellectual property rights (who generated the mouse line, owner of the mouse line)

Laboratory Animal Genetic Services (LAGS) provides MD Anderson investigators with cost - effective, customized genome scans using polymorphic genetic markers to support rapid congenic line development and background strain characterization for mice anGenetic Services (LAGS) provides MD Anderson investigators with cost - effective, customized genome scans using polymorphic genetic markers to support rapid congenic line development and background strain characterization for mice angenetic markers to support rapid congenic line development and background strain characterization for mice and rats.

The overall score encompass several factors: reproducibility of the antibody staining in different cell lines (and if signal strength correlates with RNA expression levels); assays for enhanced antibody validation by using antibodies binding to different epitopes on the same target protein (independent antibodies), by knockdown / knockout of the target protein (genetic methods) and by matching of the signal with a GFP - tagged protein (recombinant expression); experimental evidence for location described in literature.

Despite the availability of new genome editing techniques, many genetically modified lines are maintained on a mixed genetic background; particularly those developed using ES cells.

Under a grant from the Global Diversity Trust, we are using genomic tools to develop inter-specific introgression lines, novel genetic resources that are derived from crosses between diverse wild relatives and elite, high yielding varieties of both indica and japonica rice.

«We're trying to use the genome to understand not only the differences between individual lines, but also to identify what differences, in genetic terms, are still available within maize.

These isogenic cell lines can be used not only to understand the cellular consequences of disease mutations, but also to perform high throughput genetic and pharmacological screens to both understand the underlying pathological mechanisms and to develop novel therapeutic agents to prevent or treat such diseases.

One rescued line, EH536, was maintained and used for genetic crosses involving unc - 9 (fc16).

In principle, it is enough to conduct such a procedure only once, but no one forbids us from iteratively improving our master line with the advances of new technologies, using more cells for comparison, better algorithms and methods of genetic engineering.

The study notes that a key feature of the new CRISPR tool is that it uses a protein called Cpf1, more recently referred to as Cas12a, to essentially function like scissors for cutting out and inserting a targeted line of genetic code.

By using cell lines, animal testing will be avoided and multiple genetic solution tests can be run simultaneously at low cost.

Some even believe that this breed may be the original genetic line for the Chinese Crested, as they were used in trade exchanges and as highly prized gifts.

Generally, Huskies that come from professional breeders are tested for PRA, and dogs that show positive for the disorder aren't used for breeding — to help avoid passing the disease down the genetic line.

The excessive use of inbreeding and line breeding on such a dog will further reduce genetic diversity.

Many breeders use DNA testing to confirm and record the genetic history of their lines for many generations.

The use of these guidelines can assist breeders in making objective breeding decisions for genetic - disease management, while continuing their breeding lines.

These puppy mills are not doing it for the love of the breed... keeping genetic disorders and bad tempraments out of their lines and breeding the best and healthiest for their breed... they are doing it for money, and the Amish communites in my state and the state I used to live in are major players in puppymills.

Although there are quite a few Great Dane breeders worldwide, be sure to buy your puppy from a breeder who uses genetic testing to help ensure the health of your future puppy and the line as a whole.

The loss of genetic diversity in purebred dogs can be attributed to two major population bottleneck events: the first occurring during domestication; and the second arising from breed formation where the repeated use of popular sires, line breeding, breeding for specific phenotypic traits, and promotion of the breed barrier rule, contributed to overall loss in genetic variation [15 - 19].