«We've been able to identify some of
the genetic mechanisms for the changes we see,» Rosenblum says.
Not exact matches
@Bill Deacon,»... evolutionary biology can not provide a positive causation
for the digital encoding of these strands...» I'm not certain why you use the loaded language or «digital encoding», but evolution does provide a
mechanism for changes in the
genetic makeup of all organisms.
«The study provides new insights into evolution and
genetic adaptation, and establishes a framework
for investigating the biological
mechanisms behind disease resistance and adaptation to climate, knowledge that could be vital
for protecting honeybees in a rapidly
changing world,» says Matthew Webster.
However, while the
genetic factors responsible
for reprogramming are well known, the
mechanisms underlying the responses to induced gene expression
changes are not as clear.
Early investigations into the nature of
genetic evolution proposed two potential
mechanisms for the origin of new features: gene duplication and divergence, and regulatory
changes in gene expression.
This substantial input of variation from wild ancestors has provided the raw material
for phenotypic
change, but unique development and
genetic mechanisms may also have assisted the course of artificial selection.
It is interesting that biology has, in the case, provided a universal theory based on a single simple
mechanism (if we include
genetic drift and neutral theory, though admittedly not part of Darwin's formally stated understanding), whereas physics has not done so
for climate
change, given that it is potentially caused by many different
mechanisms.
Several candidate
mechanisms of CRCI have been proposed, including inflammation and cytokine dysregulation, chemotherapy - induced epigenetic
changes, blood — brain barrier disruption, hormone deficiencies, oxidative DNA damage and shortened telomere length, and
genetic susceptibility.21 — 26 However, the heterogeneity and design limitations within the emerging body of evidence have led to recommendations
for harmonising study methodologies and moving towards multisite, longitudinal research.3 27 Such approaches would support the demonstration of robust relationships between measurable biological processes and cognitive outcomes.
Advances in neuroscience have revealed that the process of brain development is driven by a dynamic interaction between the genome (nature) and the environment (nurture).25 Epigenetic
mechanisms like DNA methylation and histone acetylation are able to transduce experiences with the environment into long - lasting, even intergenerational
changes in gene expression.26 — 35 So although the inherited
genetic program is thought to provide a general blueprint
for brain architecture, the environment is able to influence which genes are used, when they are used during the course of development, and where they are used within the developing brain.